• 1. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 3. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 4. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 5. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzophenones

Introduction to (3-Benzoylphenyl)acetonitrile (CAS No. 21288-34-6)

(3-Benzoylphenyl)acetonitrile, also known by its CAS registry number CAS No. 21288-34-6, is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, materials science, and pharmacology. This compound, with its unique structure and functional groups, serves as a valuable building block in the construction of complex molecules and functional materials. Recent advancements in synthetic methodologies and its applications have further highlighted its potential in both academic research and industrial settings.

The molecular structure of (3-Benzoylphenyl)acetonitrile comprises a benzoyl group attached to a phenyl ring at the 3-position, with an acetonitrile group further substituting the phenyl ring. This arrangement endows the compound with distinct electronic and steric properties, making it suitable for various chemical transformations. The benzoyl group acts as an electron-withdrawing substituent, which can influence the reactivity of the molecule in different reaction environments. Meanwhile, the acetonitrile group introduces additional functionality, enabling further modifications or applications in areas such as polymerization or drug delivery systems.

Recent studies have explored the use of (3-Benzoylphenyl)acetonitrile in the synthesis of advanced materials, including stimuli-responsive polymers and organic semiconductors. For instance, researchers have employed this compound as a precursor for constructing self-healing polymers, where its ability to undergo reversible covalent bond formations plays a critical role. Additionally, its application in organic electronics has been investigated, particularly in the development of high-performance organic field-effect transistors (OFETs). The compound's electronic properties make it a promising candidate for enhancing charge transport characteristics in such devices.

In the pharmaceutical industry, (3-Benzoylphenyl)acetonitrile has been utilized as an intermediate in drug discovery programs targeting various therapeutic areas. Its structural flexibility allows for the incorporation of diverse functional groups, facilitating the design of bioactive molecules with improved pharmacokinetic profiles. Recent research has focused on its role in developing inhibitors for kinases and other enzyme targets, leveraging its ability to form stable interactions with biological macromolecules.

The synthesis of (3-Benzoylphenyl)acetonitrile typically involves multi-step organic reactions, including Friedel-Crafts acylation and subsequent cyanation processes. These methods have been optimized to achieve high yields and selectivity, ensuring scalability for both laboratory and industrial production. Moreover, green chemistry approaches have been integrated into its synthesis pathways, reducing environmental impact while maintaining product quality.

From an environmental standpoint, understanding the fate and toxicity of (3-Benzoylphenyl)acetonitrile is crucial for its safe handling and application. Recent toxicological studies have evaluated its potential risks to aquatic organisms and human health. These studies suggest that while the compound exhibits moderate toxicity under certain conditions, proper risk management strategies can mitigate adverse effects.

In conclusion, (3-Benzoylphenyl)acetonitrile (CAS No. 21288-34-6) stands as a pivotal compound in modern chemistry due to its diverse applications and adaptability across multiple disciplines. Its continued exploration in cutting-edge research ensures that it remains at the forefront of innovation in materials science, pharmaceuticals, and beyond.

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• 58422-85-8(Benzeneacetonitrile, 2-acetyl- (9CI))
• 14271-73-9(4-Methylbenzoyl Cyanide)
• 32446-66-5(4,4'-Dicyanobenzophenone)
• 55211-74-0(2-(4-formylphenyl)acetonitrile)
• 613-90-1(Benzoyl cyanide)
• 1503-49-7(4-Benzoylbenzonitrile)
• 10266-44-1(Benzeneacetonitrile,3-acetyl-)
• 6136-62-5(3-Benzoylbenzonitrile)