• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 3. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
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  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 5. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

5-Butyryl-2-chlorophenylboronic Acid: A Comprehensive Overview

The compound 5-Butyryl-2-chlorophenylboronic acid (CAS No. 2096330-82-2) is a highly specialized boronic acid derivative that has garnered significant attention in the fields of organic synthesis, materials science, and drug discovery. This compound is characterized by its unique structure, which combines a boronic acid group with a substituted aromatic ring. The presence of the butyryl group at the 5-position and a chlorine atom at the 2-position imparts distinct chemical properties, making it a valuable building block in various synthetic strategies.

Boronic acids, in general, are known for their versatility in cross-coupling reactions, particularly the Suzuki-Miyaura coupling. This reaction has revolutionized the field of organic synthesis by enabling the formation of carbon-carbon bonds under mild conditions. The 5-Butyryl-2-chlorophenylboronic acid is no exception, as it serves as an excellent substrate for such reactions. Recent studies have highlighted its utility in constructing complex aromatic systems with high precision and efficiency.

The structural features of 5-Butyryl-2-chlorophenylboronic acid make it particularly suitable for applications in drug design. The butyryl group introduces lipophilicity, which can enhance the bioavailability of drug candidates. Meanwhile, the chlorine substituent at the 2-position can influence the electronic properties of the aromatic ring, potentially modulating pharmacokinetic profiles. Researchers have explored its use in developing novel anti-inflammatory agents and anticancer drugs, where precise control over molecular interactions is critical.

In terms of synthesis, 5-Butyryl-2-chlorophenylboronic acid is typically prepared through a multi-step process involving nucleophilic aromatic substitution and subsequent functionalization. Recent advancements in catalytic methods have streamlined its production, reducing costs and improving yields. These improvements have made the compound more accessible for both academic and industrial applications.

From a materials science perspective, 5-Butyryl-2-chlorophenylboronic acid has been investigated for its potential in creating advanced materials such as conductive polymers and optoelectronic devices. Its ability to participate in cross-coupling reactions allows for the construction of highly ordered structures with tailored electronic properties. Emerging research suggests that these materials could find applications in next-generation electronics and energy storage systems.

Moreover, the compound's stability under various reaction conditions makes it an attractive candidate for high-throughput screening processes. Its compatibility with diverse coupling partners enables chemists to explore a wide range of structural variations, facilitating rapid lead optimization in drug discovery campaigns.

In summary, 5-Butyryl-2-chlorophenylboronic acid (CAS No. 2096330-82-2) stands out as a versatile and valuable compound with applications spanning multiple disciplines. Its unique structure, coupled with advancements in synthetic methodologies and material science applications, positions it as a key player in modern chemical research. As ongoing studies continue to uncover new potential uses, this compound is poised to make significant contributions to both scientific innovation and industrial development.

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