• 1. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 4. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 5. Distributed research: a new paradigm for undergraduate research and global problem solving?
  Bruce Parkinson Energy Environ. Sci., 2010,3, 509-511

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

3-Amino-1H-indazole-5-carbonitrile (CAS No: 20925-62-6)

3-Amino-1H-indazole-5-carbonitrile, also known by its CAS registry number 20925-62-6, is a heterocyclic organic compound with significant potential in various fields of chemical research and application. This compound belongs to the class of indazoles, which are bicyclic aromatic systems consisting of a benzene ring fused to an imidazole ring. The presence of the amino group (-NH?) at the 3-position and the cyano group (-CN) at the 5-position imparts unique chemical properties, making it a valuable molecule in drug discovery, material science, and synthetic chemistry.

The synthesis of 3-Amino-1H-indazole-5-carbonitrile typically involves multi-step reactions, often utilizing intermediates such as indazoles or their derivatives. Recent advancements in catalytic methods and green chemistry have enabled more efficient and environmentally friendly routes for its production. For instance, researchers have explored the use of transition metal catalysts, such as palladium complexes, to facilitate coupling reactions that lead to the formation of this compound. These methods not only improve yield but also reduce the environmental footprint associated with traditional synthetic pathways.

In terms of applications, 3-Amino-1H-indazole-5-carbonitrile has garnered attention in the pharmaceutical industry due to its potential as a building block for bioactive compounds. Its structure allows for various functionalization strategies, enabling the creation of molecules with diverse biological activities. For example, studies have shown that derivatives of this compound exhibit promising anti-inflammatory and anticancer properties. Recent research has focused on optimizing its pharmacokinetic profiles to enhance bioavailability and reduce toxicity, making it a candidate for preclinical trials.

Beyond pharmacology, 3-Amino-1H-indazole-5-carbonitrile has also found applications in material science. Its ability to form coordination complexes with metal ions makes it a potential candidate for designing novel materials with magnetic or electronic properties. For instance, researchers have investigated its use in creating metal-organic frameworks (MOFs) that exhibit high surface area and porosity, suitable for gas storage and catalysis.

The chemical stability and reactivity of 3-Amino-1H-indazole-5-carbonitrile are influenced by its functional groups. The amino group acts as a nucleophile, enabling it to participate in substitution and addition reactions. Meanwhile, the cyano group contributes to the molecule's electron-withdrawing nature, enhancing its electrophilic character in certain contexts. These properties make it versatile in organic synthesis, where it can serve as both an electrophilic acceptor and a nucleophilic donor depending on reaction conditions.

In recent years, computational chemistry has played a pivotal role in understanding the electronic structure and reactivity of 3-Amino-1H-indazole-5-carbonitrile. Density functional theory (DFT) calculations have provided insights into its molecular orbitals and interaction patterns with other molecules. Such studies are crucial for predicting its behavior in complex chemical environments and designing tailored syntheses for specific applications.

In conclusion, 3-Amino-1H-indazole-5-carbonitrile (CAS No: 20925-62-6) is a multifaceted compound with diverse applications across chemistry and related disciplines. Its unique structure, coupled with advancements in synthetic methods and computational tools, positions it as a valuable asset in both academic research and industrial development.

• 830321-62-5(1H-Indazol-3-amine, 5,7-dimethyl-)
• 368426-75-9(6-(aminomethyl)-1H-indazol-3-amine)
• 267413-32-1(3-Amino-1H-indazole-6-carbonitrile)
• 1137451-25-2(3-Amino-1H-indazole-7-carbonitrile)
• 267876-23-3(3-amino-1H-Indazole-5-methanamine)
• 1240518-54-0(3-Amino-1H-indazole-4-carbonitrile)
• 1000343-59-8(3-Amino-7-methyl (1H)indazole)
• 88805-94-1(5-methyl-1H-indazol-3-ylamine)
• 1245645-87-7(5-Ethynyl-1H-indazol-3-amine)
• 835616-39-2(6-Methyl-1H-indazol-3-ylamine)