• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 3. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

3-Amino-1H-indazole-4-carbonitrile (CAS No. 1240518-54-0): A Comprehensive Overview

3-Amino-1H-indazole-4-carbonitrile, also known by its CAS registry number CAS No. 1240518-54-0, is a heterocyclic organic compound with significant potential in various fields of chemical research and application. This compound belongs to the indazole family, a class of bicyclic structures consisting of a benzene ring fused to an imidazole moiety. The presence of an amino group (-NH?) at the 3-position and a cyano group (-CN) at the 4-position imparts unique chemical properties, making it a valuable molecule in drug discovery, material science, and organic synthesis.

The synthesis of 3-Amino-1H-indazole-4-carbonitrile typically involves multi-step reactions, often utilizing intermediates such as indazoles or their derivatives. Recent advancements in catalytic methods and green chemistry have enabled more efficient and environmentally friendly routes to this compound. For instance, researchers have explored the use of transition metal catalysts to facilitate coupling reactions, significantly improving yields and reducing reaction times.

In the realm of pharmacology, 3-Amino-1H-indazole-4-carbonitrile has garnered attention due to its potential as a lead compound in drug development. Studies have demonstrated its ability to modulate various biological targets, including kinases and receptors, which are implicated in diseases such as cancer and neurodegenerative disorders. For example, a recent study published in the Journal of Medicinal Chemistry highlighted its inhibitory effects on a specific kinase involved in tumor growth, suggesting its potential as an anti-cancer agent.

Beyond pharmacology, 3-Amino-1H-indazole-4-carbonitrile has found applications in material science. Its nitrogen-rich structure makes it a promising candidate for the development of coordination polymers and metal-organic frameworks (MOFs). These materials are highly sought after for their potential in gas storage, catalysis, and sensing technologies. Researchers have reported the successful incorporation of this compound into MOFs with enhanced porosity and stability, opening new avenues for industrial applications.

The chemical versatility of 3-Amino-1H-indazole-4-carbonitrile also extends to organic synthesis. Its amino group can act as a nucleophile in various reactions, enabling the construction of complex molecular architectures. Recent advancements in click chemistry have further expanded its utility, allowing for rapid and selective modifications of this compound to create derivatives with tailored properties.

In conclusion, 3-Amino-1H-indazole-4-carbonitrile (CAS No. 1240518-54-0) is a multifaceted compound with significant implications across diverse scientific disciplines. Its unique chemical structure, coupled with recent breakthroughs in synthesis and application methodologies, positions it as a key molecule in advancing both fundamental research and practical innovations.

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