• 1. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 2. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Toluenes Tosyl compounds

Benzenesulfonamide, 4-methyl-2-nitro- (CAS No. 20901-98-8)

Benzenesulfonamide, 4-methyl-2-nitro- is a chemical compound with the CAS registry number 20901-98-8. This compound belongs to the class of sulfonamides, which are widely studied in organic chemistry due to their versatile applications in pharmaceuticals, agrochemicals, and materials science. The molecular structure of this compound consists of a benzene ring substituted with a methyl group at the 4-position and a nitro group at the 2-position, with a sulfonamide functional group attached to the benzene ring.

The sulfonamide functional group (-SO?NH?) is known for its ability to form hydrogen bonds, which contributes to its potential as a bioisostere in drug design. Recent studies have explored the role of sulfonamides in modulating enzyme activity and receptor binding, making them valuable candidates in medicinal chemistry. The substitution pattern of this compound—specifically the methyl and nitro groups—plays a significant role in its electronic properties and reactivity. The nitro group at the 2-position introduces electron-withdrawing effects, which can influence the compound's stability and reactivity during synthesis and application.

From a synthetic perspective, Benzenesulfonamide, 4-methyl-2-nitro- can be prepared through various routes, including nucleophilic aromatic substitution and coupling reactions. Researchers have optimized these methods to improve yield and selectivity, particularly by employing catalytic systems or directing groups to control regioselectivity. For instance, recent advancements in transition-metal-catalyzed cross-coupling reactions have enabled more efficient syntheses of substituted sulfonamides.

In terms of applications, this compound has shown promise in several fields. In pharmacology, it has been investigated as a potential lead molecule for anti-inflammatory and anti-cancer agents due to its ability to inhibit specific kinases or modulate cellular signaling pathways. Additionally, its electronic properties make it a candidate for use in organic electronics or as a precursor for advanced materials.

The environmental impact and safety profile of Benzenesulfonamide, 4-methyl-2-nitro- are also areas of interest. Studies have assessed its biodegradability and toxicity under various conditions. While it exhibits moderate stability under standard conditions, its degradation products are being evaluated for their environmental fate and potential risks.

In conclusion, Benzenesulfonamide, 4-methyl-2-nitro- (CAS No. 20901-98-8) is a multifaceted compound with significant potential across diverse chemical disciplines. Its unique structure and functional groups make it an intriguing subject for both fundamental research and applied development. As ongoing studies continue to uncover new insights into its properties and applications, this compound remains an important focus in contemporary chemical research.

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