• 1. A fluoro-alkene mimic of Gly-trans-Pro produces a stable collagen triple helix
  Paul J. Arcoria,Felicia A. Etzkorn Org. Biomol. Chem. 2023 21 4039
• 2. H6phospa-trastuzumab: bifunctional methylenephosphonate-based chelator with 89Zr, 111In and 177Lu
  Eric W. Price,Brian M. Zeglis,Jason S. Lewis,Michael J. Adam,Chris Orvig Dalton Trans. 2014 43 119
• 3. Modular syntheses of H4octapa and H2dedpa, and yttrium coordination chemistry relevant to 86Y/90Y radiopharmaceuticals
  Eric W. Price,Jacqueline F. Cawthray,Michael J. Adam,Chris Orvig Dalton Trans. 2014 43 7176
• 4. The synthesis of a series of adenosine A3 receptor agonists
  Kenneth J. Broadley,Erica Burnell,Robin H. Davies,Alan T. L. Lee,Stephen Snee,Eric J. Thomas Org. Biomol. Chem. 2016 14 3765
• 5. Synthetic and mechanistic insight into nosylation of glycine residues
  Nicolai Stuhr-Hansen,Theis Ivan S?lling,Kristian Str?mgaard Org. Biomol. Chem. 2013 11 2288

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Comprehensive Analysis of 2-Nitrobenzene-1-sulfonamide (CAS No. 5455-59-4): Properties, Applications, and Industry Trends

2-Nitrobenzene-1-sulfonamide (CAS No. 5455-59-4) is a specialized organic compound with a molecular formula of C₆H₆N₂O₄S. This nitro-substituted sulfonamide derivative has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. The compound's sulfonamide functional group and nitro aromatic system contribute to its diverse reactivity, making it a valuable intermediate in synthetic chemistry.

Recent advancements in heterocyclic compound synthesis have highlighted the role of 2-nitrobenzene sulfonamide derivatives as key building blocks. Researchers are particularly interested in its potential for creating bioactive molecules, with studies showing promise in developing novel enzyme inhibitors. The electron-withdrawing nitro group at the ortho position significantly influences the compound's electronic properties, affecting its hydrogen bonding capacity and molecular interactions.

From an industrial perspective, 5455-59-4 has shown growing importance in specialty chemical manufacturing. Its applications extend to photoactive materials and organic semiconductors, aligning with current trends in green chemistry and sustainable synthesis. The compound's stability under various conditions makes it suitable for high-temperature reactions, a feature increasingly demanded in process chemistry optimization.

Analytical characterization of 2-nitrobenzene-1-sulfonamide typically involves advanced techniques such as HPLC purity analysis, mass spectrometry, and X-ray crystallography. These methods confirm the compound's structural integrity and help establish quality control parameters for industrial applications. Recent publications have focused on improving synthetic yield through catalytic methods, addressing common challenges in nitroaromatic chemistry.

The safety profile of CAS 5455-59-4 has been extensively studied, with proper handling procedures established for laboratory and industrial use. Current research emphasizes waste minimization strategies in its production, reflecting the chemical industry's shift toward environmentally friendly processes. These developments align with growing consumer interest in sustainable chemical solutions and green alternatives across multiple sectors.

Market analysis indicates rising demand for nitro-substituted sulfonamides in pharmaceutical intermediates and material science applications. The unique electronic properties of 2-nitrobenzene-1-sulfonamide make it particularly valuable for developing advanced functional materials, including organic electronic devices and smart coatings. These applications capitalize on the compound's photophysical characteristics and thermal stability.

Future research directions for 5455-59-4 include exploring its potential in medicinal chemistry and catalysis. The compound's ability to serve as a versatile synthon continues to attract interest from both academic and industrial researchers. With the growing emphasis on molecular diversity in drug discovery, nitrobenzene sulfonamide derivatives are expected to play an increasingly important role in developing next-generation therapeutics.

From a regulatory standpoint, manufacturers of 2-nitrobenzene-1-sulfonamide must comply with international standards for chemical safety and quality assurance. The compound's handling and storage require adherence to established industrial hygiene practices, ensuring safe utilization across various applications. These considerations are particularly important for companies operating in global supply chains and regulated industries.

Technological advancements in chemical synthesis automation have improved the production efficiency of nitroaromatic sulfonamides like 5455-59-4. Modern continuous flow chemistry systems demonstrate particular promise for scaling up production while maintaining reaction selectivity and product purity. These innovations address the pharmaceutical industry's need for reliable synthetic routes to complex intermediates.

In conclusion, 2-nitrobenzene-1-sulfonamide (CAS No. 5455-59-4) represents an important class of nitroaromatic compounds with wide-ranging applications. Its significance in organic synthesis, combined with emerging uses in advanced materials, positions this compound as a valuable asset in contemporary chemical research and industrial applications. Ongoing studies continue to reveal new dimensions of its chemical versatility and practical utility across multiple scientific disciplines.

• 13852-81-8(4-chloro-2-nitrobenzene-1-sulfonamide)
• 54734-85-9(2-Amino-5-nitrobenzenesulfonamide)
• 73463-44-2(Benzenesulfonamide, N-[(2-nitrophenyl)thio]-)
• 121-52-8(3-Nitrobenzenesulfonamide)
• 6325-93-5(4-Nitrobenzenesulfonamide)
• 89581-41-9(4-bromo-2-nitrobenzene-1-sulfonamide)
• 23530-40-7(N-Methyl-2-nitrobenzenesulfonamide)
• 5906-99-0(2-Nitrobenzenesulfonohydrazide)
• 68379-05-5(5-Chloro-2-nitrobenzenesulfonamide)
• 73901-01-6(2,4-Dinitrobenzenesulfonamide)