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  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
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  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

6-Chloro-5-Ethyl-1,2,3,4-Tetrahydropyrimidine-2,4-Dione: A Comprehensive Overview

6-Chloro-5-Ethyl-1,2,3,4-Tetrahydropyrimidine-2,4-Dione, also known by its CAS Registry Number 20295-24-3, is a significant compound in the field of organic chemistry. This compound belongs to the class of tetrahydropyrimidinediones, which are known for their diverse applications in pharmaceuticals and agrochemicals. The structure of this compound is characterized by a six-membered ring system with two ketone groups and a chlorine atom at the 6th position and an ethyl group at the 5th position. These substituents play a crucial role in determining its chemical properties and biological activity.

The synthesis of 6-Chloro-5-Ethyl-Tetrahydropyrimidine Dione involves a series of well-established organic reactions. Typically, the process begins with the preparation of a suitable pyrimidine derivative, followed by functional group transformations to introduce the chlorine and ethyl substituents. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses of this compound. Researchers have also explored the use of microwave-assisted synthesis to optimize reaction conditions and improve yields.

In terms of physical properties, this compound exhibits a melting point of approximately 180°C and is sparingly soluble in water but readily soluble in organic solvents such as dichloromethane and acetonitrile. These properties make it suitable for various applications where controlled solubility is required. The compound's stability under different pH conditions has also been studied extensively, with findings indicating moderate stability in neutral to slightly alkaline environments.

The biological activity of CAS No 20295-24-3 has been a focal point of recent research. Studies have demonstrated its potential as an inhibitor of certain enzymes involved in metabolic pathways. For instance, investigations into its effects on histone deacetylases (HDACs) have shown promising results, suggesting its potential role in epigenetic therapy. Additionally, research into its anti-inflammatory properties has revealed its ability to modulate cytokine production in vitro.

In the agricultural sector, this compound has been evaluated for its pesticidal activity. Field trials have indicated that it exhibits moderate efficacy against certain insect pests and fungal pathogens. However, further studies are required to fully understand its mode of action and optimize its application rates for sustainable pest management.

Recent breakthroughs in computational chemistry have enabled researchers to model the interactions of 6-Chloro-5-Ethyl-Tetrahydropyrimidine Dione with various biological targets at an atomic level. These models provide valuable insights into the molecular mechanisms underlying its pharmacological effects and guide the design of more potent derivatives.

In conclusion, CAS No 20295-24-3, or 6-Chloro-5-Ethyl-Tetrahydropyrimidine Dione, stands as a versatile compound with significant potential across multiple fields. Its unique chemical structure, coupled with advancements in synthetic methods and biological studies, positions it as a key player in future drug discovery and agrochemical development efforts.

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