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  Daijie Wang,Xiangyun Song,Huijiao Yan,Mengmeng Guo,Ruiming Fu,Hailong Jiang,Heng Zhu,Xiao Wang RSC Adv. 2018 8 34321
• 2. Profile of the main bioactive compounds and in vitro biological activity of different solvent extracts from Ginkgo biloba exocarp
  Na Cui,Liangliang Zhang,Meiping Quan,Jianguo Xu RSC Adv. 2020 10 45105
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  Xin-Guang Liu,Xu Lu,Wen Gao,Ping Li,Hua Yang Nat. Prod. Rep. 2022 39 474
• 4. A critical review of ginkgolic acids in Ginkgo biloba leaf extract (EGb): toxicity and technologies to remove ginkgolic acids and their promising bioactivities
  Isaac Duah Boateng Food Funct. 2022 13 9226
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Salicylic acids
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients Standard Substances
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of Ginkgolic Acid (C13:0) (CAS No. 20261-38-5): Properties, Applications, and Research Insights

Ginkgolic Acid (C13:0), identified by its CAS number 20261-38-5, is a naturally occurring phenolic compound derived from the leaves and seeds of the Ginkgo biloba tree. This compound belongs to the alkylphenol family and is characterized by its 13-carbon side chain (C13:0), which contributes to its unique biological activities. In recent years, Ginkgolic Acid has garnered significant attention in the fields of natural product research, cosmetics, and pharmacology, particularly due to its potential anti-inflammatory, antimicrobial, and neuroprotective properties.

The growing interest in plant-derived bioactive compounds has positioned Ginkgolic Acid (C13:0) as a subject of extensive scientific inquiry. Researchers are increasingly exploring its mechanisms of action, particularly its ability to modulate cellular pathways linked to oxidative stress and inflammation. For instance, studies suggest that this compound may inhibit key enzymes like tyrosinase, making it a promising candidate for skin-lightening formulations and anti-aging skincare products. These applications align with current consumer trends favoring clean beauty and sustainable ingredients.

From a structural perspective, Ginkgolic Acid (C13:0) features a salicylic acid core with a long hydrophobic chain, which enhances its lipid solubility and membrane permeability. This property is critical for its bioavailability and interaction with cellular targets. Analytical techniques such as HPLC and mass spectrometry are commonly employed to quantify and characterize this compound in Ginkgo biloba extracts, ensuring purity and consistency for industrial applications.

In the realm of natural medicine, Ginkgolic Acid is often discussed alongside other Ginkgo biloba constituents like flavonoids and terpenoids. However, its distinct pharmacological profile sets it apart. Recent in vitro studies highlight its potential as an antibacterial agent against drug-resistant pathogens, a topic of high relevance given the global rise in antimicrobial resistance (AMR). This has spurred interest in developing Ginkgolic Acid-based therapeutics as complementary alternatives to conventional antibiotics.

Despite its benefits, the use of Ginkgolic Acid (C13:0) requires careful consideration due to reports of allergenic potential in sensitive individuals. Regulatory bodies emphasize the importance of quality control and standardization in commercial products containing this compound. Manufacturers are increasingly adopting green extraction methods, such as supercritical CO2 extraction, to minimize residual solvents and enhance sustainability—a practice highly valued in today’s eco-conscious market.

Looking ahead, the integration of Ginkgolic Acid into functional foods and nutraceuticals presents exciting opportunities. Its purported neuroprotective effects align with the booming market for cognitive health supplements, driven by an aging population and rising awareness of brain health. Furthermore, advancements in nanotechnology may enable targeted delivery systems to improve its efficacy and reduce side effects.

In summary, Ginkgolic Acid (C13:0) (CAS No. 20261-38-5) exemplifies the convergence of traditional knowledge and modern science. Its multifaceted applications—from cosmeceuticals to antimicrobial research—underscore its value as a bioactive natural compound. As research continues to unravel its full potential, this molecule is poised to play a pivotal role in addressing contemporary health and wellness challenges.

• 69-72-7(Salicylic acid)
• 72-48-0(Alizarin)
• 65-49-6(4-Aminosalicylic acid)
• 77-09-8(Phenolphthalein)
• 81-64-1(Quinizarin)
• 50-85-1(4-Methylsalicylic acid)
• 85-52-9(2-Benzoylbenzoic acid)
• 83-30-7(2,4,6-Trihydroxybenzoic acid)
• 83-40-9(3-Methylsalicylic acid)
• 50-78-2(Aspirin)