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Comprehensive Overview of 3-(2-Thienyl)-1H-pyrazol-4-ylmethanol (CAS No. 194546-14-0): Properties, Applications, and Industry Insights

3-(2-Thienyl)-1H-pyrazol-4-ylmethanol (CAS No. 194546-14-0) is a heterocyclic compound that has garnered significant attention in pharmaceutical and material science research due to its unique structural features. The molecule combines a thienyl group with a pyrazole core, functionalized by a hydroxymethyl moiety, making it a versatile intermediate for drug discovery and organic synthesis. Its CAS registry number, 194546-14-0, is frequently searched in chemical databases, reflecting its relevance in high-value applications.

In recent years, the demand for 3-(2-Thienyl)-1H-pyrazol-4-ylmethanol has surged, driven by its potential in developing small-molecule inhibitors and biologically active compounds. Researchers are particularly interested in its role as a scaffold for kinase inhibitors, a hot topic in oncology and inflammation therapeutics. The compound’s thiophene-pyrazole hybrid structure aligns with trends in fragment-based drug design, a strategy widely discussed in AI-driven drug discovery forums.

From a synthetic chemistry perspective, CAS No. 194546-14-0 exemplifies the growing interest in sustainable synthetic routes. Laboratories are optimizing its production using catalytic methods and green solvents, addressing environmental concerns raised in platforms like Google Scholar and PubMed. Its hydroxymethyl group also enables facile derivatization, a feature highlighted in patents focusing on prodrug development and targeted delivery systems.

The compound’s physicochemical properties, such as moderate lipophilicity and hydrogen-bonding capacity, make it suitable for structure-activity relationship (SAR) studies. These characteristics are frequently queried in chemical search engines like SciFinder and Reaxys. Additionally, its thermal stability and solubility profile are critical for formulation scientists exploring oral bioavailability enhancement, a recurring theme in pharmaceutical Q&A platforms.

Beyond pharmaceuticals, 3-(2-Thienyl)-1H-pyrazol-4-ylmethanol is investigated for organic electronics due to its conjugated π-system. This aligns with industry trends toward flexible electronics and OLED materials, topics dominating tech-focused search queries. Its thienyl group contributes to charge transport properties, a feature leveraged in semiconductor research.

Quality control of CAS No. 194546-14-0 involves advanced analytical techniques like HPLC-MS and NMR spectroscopy, often discussed in analytical chemistry communities. Regulatory compliance, including ICH guidelines, is another frequent search keyword linked to this compound, emphasizing its adherence to global standards for high-purity chemicals.

In summary, 3-(2-Thienyl)-1H-pyrazol-4-ylmethanol represents a nexus of interdisciplinary research, bridging medicinal chemistry, materials science, and green synthesis. Its CAS number, 194546-14-0, serves as a gateway to extensive scientific literature, while its applications resonate with contemporary search trends in drug discovery and advanced materials.

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