• 1. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 2. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
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• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
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• 4. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Acrylic acids and derivatives

N-Methoxy-N-Methylacrylamide (CAS No. 193634-77-4): An Overview of Its Properties, Applications, and Recent Research

N-Methoxy-N-methylacrylamide (NMMA), with the CAS number 193634-77-4, is a versatile compound that has garnered significant attention in the fields of organic synthesis, polymer science, and pharmaceutical research. This compound is characterized by its unique structure, which includes a methoxy and a methyl group attached to the nitrogen atom of an acrylamide moiety. The combination of these functional groups imparts NMMA with a range of valuable properties, making it a valuable building block in various applications.

The chemical formula of N-methoxy-N-methylacrylamide is C6H11NO2, and it is typically synthesized through the reaction of acryloyl chloride with N-methoxymethylamine. This synthesis method ensures high purity and yield, making NMMA readily available for both academic and industrial use. The compound is a colorless liquid at room temperature and exhibits good solubility in common organic solvents such as ethanol, acetone, and dimethylformamide (DMF).

One of the key properties of N-methoxy-N-methylacrylamide is its reactivity. The presence of the acrylamide group makes NMMA highly reactive towards nucleophilic addition reactions, which is crucial for its use in polymerization processes. Additionally, the methoxy and methyl groups provide steric and electronic effects that can influence the reactivity and selectivity of the compound in various chemical transformations. These properties make NMMA an excellent monomer for the synthesis of functional polymers with tailored properties.

In the field of polymer science, N-methoxy-N-methylacrylamide has been extensively studied for its potential in creating advanced materials. Recent research has focused on the development of stimuli-responsive polymers using NMMA as a monomer. For example, a study published in the Journal of Polymer Science demonstrated that copolymers derived from NMMA exhibit temperature-responsive behavior, making them suitable for applications in drug delivery systems and smart coatings. The ability to fine-tune the properties of these polymers by varying the ratio of NMMA to other monomers has opened up new avenues for material design.

Beyond polymer science, N-methoxy-N-methylacrylamide has also found applications in pharmaceutical research. Its unique structure makes it a valuable intermediate in the synthesis of bioactive compounds. A notable example is its use in the synthesis of prodrugs, which are inactive precursors that are converted into active drugs within the body. A recent study published in Organic & Biomolecular Chemistry reported the successful synthesis of a prodrug using NMMA as a key intermediate. The prodrug showed improved solubility and stability compared to its parent drug, highlighting the potential of NMMA in enhancing drug delivery efficiency.

The safety profile of N-methoxy-N-methylacrylamide is another important aspect to consider. While it is generally considered safe for laboratory use when proper handling procedures are followed, it is important to note that like many organic compounds, NMMA should be handled with care to avoid inhalation or skin contact. Safety data sheets (SDS) provide detailed information on handling and storage guidelines to ensure safe use.

In conclusion, N-methoxy-N-methylacrylamide (CAS No. 193634-77-4) is a multifunctional compound with a wide range of applications in organic synthesis, polymer science, and pharmaceutical research. Its unique structure and reactivity make it an invaluable building block for creating advanced materials and bioactive compounds. Ongoing research continues to explore new possibilities for NMMA, further solidifying its importance in these fields.

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