Production Method 1

1798-85-2

1932673-11-4

1075178-25-4

15185-59-8

Reaction Conditions

1.1R:F3CCO2H, R:NaNO2, S:CHCl3, 10-15 min, rt; 0-5°C; 5°C → 20°C; 1 h, 20°C
1.2C:Al2O3, 20°C

Reference

Isomerization of 3-unsubstituted 4,5-dihydroisoxazoles over alumina. A new synthesis of β-hydroxy nitriles

By Mochalov, S. S. et al, Russian Journal of Organic Chemistry, 2016, 52(3), 397-403

Isoxazole, 5-(3-bromophenyl)-4,5-dihydro- Raw materials

• 1-Bromo-3-cyclopropylbenzene

Isoxazole, 5-(3-bromophenyl)-4,5-dihydro- Preparation Products

• 3-(3-Bromophenyl)-3-hydroxypropanenitrile (1075178-25-4)
• 3-(3-Bromophenyl)acrylaldehyde (15185-59-8)
• Isoxazole, 5-(3-bromophenyl)-4,5-dihydro- (1932673-11-4)

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