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  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
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  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
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  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Chlorobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Chlorobenzenes

Comprehensive Guide to 4-Bromo-2,6-dichloroanisole (CAS No. 19240-91-6): Properties, Applications, and Industry Insights

4-Bromo-2,6-dichloroanisole (CAS No. 19240-91-6) is a halogenated aromatic compound widely recognized for its unique chemical structure and versatile applications in organic synthesis. This compound, featuring a bromine and two chlorine substituents on an anisole backbone, has garnered significant attention in pharmaceutical, agrochemical, and material science research. Its molecular formula, C₇H₅BrCl₂O, and precise steric configuration make it a valuable intermediate for constructing complex molecules.

In recent years, the demand for halogenated anisoles like 4-Bromo-2,6-dichloroanisole has surged due to their role in developing high-performance polymers and electronic materials. Researchers are particularly interested in its potential for creating flame-retardant additives and liquid crystal displays (LCDs), aligning with the global push for sustainable and energy-efficient technologies. The compound’s stability under thermal conditions further enhances its industrial relevance.

From a synthetic perspective, CAS 19240-91-6 is often utilized in cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, to introduce aryl halide functionalities. This aligns with the growing trend of green chemistry, where chemists seek atom-efficient pathways to reduce waste. A 2023 study highlighted its use in synthesizing biologically active molecules, including potential antimicrobial agents, addressing the urgent need for novel antibiotics amid rising drug resistance.

Environmental and safety profiles of 4-Bromo-2,6-dichloroanisole are frequently queried in scientific databases. While the compound exhibits low acute toxicity, proper handling protocols—such as using personal protective equipment (PPE)—are recommended. Its persistence in aquatic systems has prompted studies on advanced oxidation processes (AOPs) for degradation, reflecting the industry’s focus on eco-friendly waste management.

The market for halogenated aromatic intermediates is projected to grow at a CAGR of 5.8% (2024–2030), driven by innovations in pharmaceutical R&D and renewable energy materials. Suppliers of CAS 19240-91-6 emphasize compliance with REACH and GMP standards, catering to stringent regulatory requirements. Analytical techniques like HPLC and GC-MS are critical for quality control, ensuring ≥98% purity for research-grade applications.

Emerging applications include its use in organic photovoltaics (OPVs), where its electron-withdrawing properties enhance light absorption efficiency. This ties into the broader discourse on carbon-neutral technologies, a hotspot in both academic and industrial circles. Additionally, its derivatives are explored for flavor and fragrance formulations, though challenges like regioselective modification remain active research areas.

For researchers sourcing 4-Bromo-2,6-dichloroanisole, factors like batch-to-batch consistency and scalability are paramount. Leading manufacturers now offer custom synthesis services to meet niche demands, from milligram to kilogram quantities. Storage recommendations typically include ambient conditions in amber glass to prevent photodegradation, a detail often overlooked in early-stage experiments.

In summary, 4-Bromo-2,6-dichloroanisole (CAS No. 19240-91-6) exemplifies the intersection of traditional organic chemistry and cutting-edge innovation. Its adaptability across sectors—from drug discovery to smart materials—positions it as a compound of enduring significance. As industries prioritize sustainability and efficiency, the scientific community’s understanding of this molecule will undoubtedly expand, unlocking new possibilities.

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