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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Carbazoles

Comprehensive Overview of 3-Methoxy-9H-carbazole (CAS No. 18992-85-3): Properties, Applications, and Industry Insights

3-Methoxy-9H-carbazole (CAS No. 18992-85-3) is a heterocyclic organic compound belonging to the carbazole family, characterized by a methoxy group at the 3-position of its aromatic structure. This compound has garnered significant attention in pharmaceutical, agrochemical, and material science research due to its unique electronic properties and versatile reactivity. With a molecular formula of C₁₃H₁₁NO and a molecular weight of 197.23 g/mol, it serves as a key intermediate in synthesizing advanced fluorescent materials, OLED emitters, and bioactive molecules.

Recent studies highlight the growing demand for 3-methoxy-9H-carbazole derivatives in organic electronics, particularly in optoelectronic devices such as organic light-emitting diodes (OLEDs) and perovskite solar cells. Its electron-rich carbazole core enables efficient charge transport, while the methoxy group enhances solubility for solution-processed thin films—a critical factor for scalable manufacturing. Industry reports project a CAGR of 8.2% (2023-2030) for carbazole-based materials, driven by the global shift toward green energy technologies and flexible displays.

In pharmaceutical applications, CAS 18992-85-3 demonstrates potential as a scaffold for anticancer agents and neuroprotective drugs. Computational studies reveal its ability to interact with biological targets like topoisomerase II and β-amyloid proteins. Researchers are exploring its structure-activity relationships (SAR) to develop novel small-molecule inhibitors, aligning with the current focus on precision medicine and targeted therapies in oncology.

The synthesis of 3-methoxy carbazole typically involves cyclization of diphenylamine derivatives or transition-metal-catalyzed cross-coupling reactions. Recent advancements in flow chemistry have improved yields (>85%) while reducing environmental impact—addressing the chemical industry's emphasis on green chemistry principles and sustainable synthesis. Analytical characterization via HPLC-MS and NMR spectroscopy confirms high purity (>98%), meeting stringent requirements for electronic-grade materials.

From a commercial perspective, suppliers list 18992-85-3 with pricing tiers ranging from $120-$450/kg depending on purity (98-99.9%) and batch size. The compound's stability under ambient conditions (melting point: 145-148°C) facilitates global logistics, though storage recommendations include protection from prolonged UV exposure due to potential photooxidation. Regulatory databases classify it as non-hazardous under standard handling conditions, simplifying compliance for industrial users.

Emerging trends suggest expanding applications in bioconjugation chemistry for diagnostic probes and photoactive biomaterials. A 2023 patent analysis shows increased filings for carbazole-modified polymers in biomedical sensors—a response to the rising demand for wearable health monitors. Furthermore, its compatibility with 3D printing resins opens possibilities in additive manufacturing of functional components.

For researchers sourcing 3-methoxy-9H-carbazole, critical considerations include supplier certifications (ISO 9001, REACH compliance), batch-to-batch consistency, and availability of custom derivatization services. Leading manufacturers now provide technical dossiers with complete spectral data and QSAR predictions, reflecting the industry's digital transformation toward data-driven chemical procurement.

• 64063-52-1(7-methoxy-3H-Benz[e]indole)
• 61822-18-2(2,7-Dimethoxy-9h-carbazole)
• 62099-77-8(7H-Pyrido[3,4-c]carbazole,10-methoxy-)
• 78304-53-7(5-phenoxy-1H-indole)
• 62099-76-7(7H-Pyrido[4,3-c]carbazole,10-methoxy-)
• 1006-94-6(5-Methoxyindole)
• 3189-13-7(6-methoxy-1H-indole)
• 2137-45-3(5-Methoxyindole)
• 117461-83-3(5-methoxy-1H-Benz[g]indole)
• 6933-49-9(2-Methoxy-9H-carbazole)