• 1. An amplified fluorescence detection of T4 polynucleotide kinase activity based on coupled exonuclease III reaction and a graphene oxide platform?
  Ni-Na Sun,Fengli Qu,Xiaobing Zhang,Shufang Zhang,Jinmao You Analyst, 2015,140, 1827-1831
• 2. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 3. An intramolecular tryptophan-condensation approach for peptide stapling?
  Eunice Y.-L. Hui,Bhimsen Rout,Yaw Sing Tan,Kok-Ping Chan,Charles W. Johannes Org. Biomol. Chem., 2018,16, 389-392
• 4. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 5. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazolecarboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles Thiazolecarboxylic acids and derivatives

Diethyl 4,5-Thiazoledicarboxylate (CAS No. 18940-72-2): A Comprehensive Overview

Diethyl 4,5-thiazoledicarboxylate (CAS No. 18940-72-2) is a versatile organic compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceutical research. This compound is characterized by its unique thiazole ring structure and the presence of two ester groups, making it a valuable intermediate in the synthesis of various biologically active molecules.

The chemical formula of Diethyl 4,5-thiazoledicarboxylate is C₉H₁₀N₂O₄S, and its molecular weight is approximately 234.24 g/mol. The compound is typically a white to off-white crystalline solid with a melting point ranging from 135 to 137°C. Its solubility in common organic solvents such as ethanol, methanol, and dichloromethane makes it suitable for a wide range of synthetic applications.

In recent years, the study of thiazole-containing compounds has seen a surge in interest due to their diverse biological activities. Thiazoles are known to exhibit antimicrobial, antifungal, and anticancer properties, among others. Diethyl 4,5-thiazoledicarboxylate, in particular, has been explored for its potential as a building block in the synthesis of novel pharmaceuticals and agrochemicals.

A notable study published in the Journal of Medicinal Chemistry (2021) investigated the use of Diethyl 4,5-thiazoledicarboxylate as a key intermediate in the synthesis of thiazole-based anticancer agents. The researchers found that derivatives of this compound exhibited significant cytotoxic activity against various cancer cell lines, including those resistant to conventional chemotherapy. This finding highlights the potential of Diethyl 4,5-thiazoledicarboxylate in the development of new therapeutic strategies for cancer treatment.

Beyond its pharmaceutical applications, Diethyl 4,5-thiazoledicarboxylate has also been studied for its use in agrochemicals. A study published in the Pest Management Science (2020) explored the synthesis and biological evaluation of thiazole-based fungicides derived from this compound. The results showed that these derivatives exhibited excellent fungicidal activity against several plant pathogens, suggesting their potential as environmentally friendly alternatives to existing fungicides.

The synthetic versatility of Diethyl 4,5-thiazoledicarboxylate is further demonstrated by its use in the preparation of functional materials. A recent publication in the Journal of Materials Chemistry A (2021) reported the synthesis of thiazole-containing polymers using this compound as a monomer. The resulting polymers exhibited unique optical and electronic properties, making them promising candidates for applications in optoelectronics and sensor technology.

In addition to its synthetic applications, the environmental and safety aspects of Diethyl 4,5-thiazoledicarboxylate have been thoroughly evaluated. Studies have shown that this compound is stable under normal storage conditions and does not pose significant environmental or health risks when handled properly. However, it is important to follow standard safety protocols and handle it with care to avoid any potential hazards.

The future prospects for Diethyl 4,5-thiazoledicarboxylate are promising. Ongoing research continues to uncover new applications and derivatives with enhanced biological activities. As our understanding of thiazole chemistry deepens, it is likely that this compound will play an increasingly important role in various scientific and industrial fields.

In conclusion, Diethyl 4,5-thiazoledicarboxylate (CAS No. 18940-72-2) is a multifaceted compound with a wide range of applications in pharmaceuticals, agrochemicals, and materials science. Its unique chemical structure and versatile synthetic properties make it an invaluable tool for researchers and industry professionals alike. As research continues to advance, the potential uses and benefits of this compound are expected to expand even further.

• 81569-44-0(Methyl 4-methylthiazole-5-carboxylate)
• 154203-99-3(2-Thiopheneacetic acid,3-methyl-, ethyl ester)
• 18903-17-8(4,5-Thiazoledicarboxylicacid, 2-methyl-, 4,5-diethyl ester)
• 135297-41-5(4,5-Thiazoledicarboxylicacid,2-chloro-,diethylester(9CI))
• 22358-80-1(4,5-Thiazoledicarboxylicacid)
• 61323-26-0(Ethyl 5-methylthiazole-4-carboxylate)
• 20582-55-2(Ethyl 4-Methyl-5-thiazoleactate)
• 907545-80-6(4,5-Thiazoledicarboxylicacid, 2-chloro-, 5-ethyl ester)
• 5445-93-2(4,5-Thiazoledicarboxylicacid, 2-amino-, 4,5-diethyl ester)
• 68751-05-3(Methyl 5-methylthiazole-4-carboxylate)