Cas no 186413-75-2 (3-Bromo-6-chloro-2-methyl-5-nitropyridine)

3-Bromo-6-chloro-2-methyl-5-nitropyridine is a halogenated nitropyridine derivative with a well-defined molecular structure, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its distinct substitution pattern—featuring bromo, chloro, methyl, and nitro functional groups—enables selective reactivity in cross-coupling reactions, nucleophilic substitutions, and other transformations. The compound’s stability and high purity make it suitable for applications in medicinal chemistry, particularly in the development of bioactive molecules and agrochemicals. Its crystalline form ensures consistent handling and storage. Researchers favor this compound for its versatility in constructing complex heterocyclic frameworks, underscoring its utility in advanced synthetic methodologies.
3-Bromo-6-chloro-2-methyl-5-nitropyridine structure
186413-75-2 structure
Product Name:3-Bromo-6-chloro-2-methyl-5-nitropyridine
CAS No:186413-75-2
MF:C6H4BrClN2O2
MW:251.465159416199
MDL:MFCD09839274
CID:135224
PubChem ID:10610778
Update Time:2025-06-08

3-Bromo-6-chloro-2-methyl-5-nitropyridine Chemical and Physical Properties

Names and Identifiers

    • 3-Bromo-6-chloro-2-methyl-5-nitropyridine
    • pyridine, 3-bromo-6-chloro-2-methyl-5-nitro-
    • 2-CHLORO-3-NITRO-5-BROMO-6-PICOLINE
    • 3-Bromo-6-chloro-2-methyl-5-nitro-pyridine
    • 5-BROMO-2-CHLORO-3-NITRO-6-PICOLINE
    • 5-bromo-2-chloro-6-methyl-3-nitropyridine
    • CL0254
    • SY019554
    • AMY28755
    • AC-24910
    • MFCD09839274
    • AKOS015851206
    • 186413-75-2
    • CS-D0784
    • SCHEMBL1558539
    • J-508676
    • FT-0652764
    • DTXSID60442508
    • DS-16970
    • EN300-1087019
    • PVECCSKVOZZRPC-UHFFFAOYSA-N
    • A4123
    • Pyridine,3-broMo-6-chloro-2-Methyl-5-nitro-
    • 3-Bromo-6-chloro-2-methyl-5-nitropyridine ,97%
    • DTXCID60393329
    • DB-003921
    • MDL: MFCD09839274
    • Inchi: 1S/C6H4BrClN2O2/c1-3-4(7)2-5(10(11)12)6(8)9-3/h2H,1H3
    • InChI Key: PVECCSKVOZZRPC-UHFFFAOYSA-N
    • SMILES: BrC1=CC(=C(N=C1C)Cl)[N+](=O)[O-]

Computed Properties

  • Exact Mass: 249.91400
  • Monoisotopic Mass: 249.91447g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 187
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.7
  • Topological Polar Surface Area: 58.7?2

Experimental Properties

  • Color/Form: Pale-yellow to Yellow-brown Solid
  • Boiling Point: 306.3℃ at 760 mmHg
  • PSA: 58.71000
  • LogP: 3.23730

3-Bromo-6-chloro-2-methyl-5-nitropyridine Security Information

3-Bromo-6-chloro-2-methyl-5-nitropyridine Customs Data

  • HS CODE:2933399090
  • Customs Data:

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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3-Bromo-6-chloro-2-methyl-5-nitropyridine Production Method

Additional information on 3-Bromo-6-chloro-2-methyl-5-nitropyridine

Comprehensive Overview of 3-Bromo-6-chloro-2-methyl-5-nitropyridine (CAS No. 186413-75-2)

3-Bromo-6-chloro-2-methyl-5-nitropyridine (CAS No. 186413-75-2) is a highly specialized heterocyclic compound that has garnered significant attention in the fields of pharmaceutical research, agrochemical development, and material science. This compound, characterized by its unique molecular structure featuring bromine, chlorine, methyl, and nitro functional groups, serves as a critical intermediate in the synthesis of advanced chemical entities. Its versatility and reactivity make it a valuable asset in modern synthetic chemistry.

The growing interest in 3-Bromo-6-chloro-2-methyl-5-nitropyridine is driven by its potential applications in drug discovery, particularly in the development of kinase inhibitors and antimicrobial agents. Researchers are increasingly exploring its utility in creating novel therapeutic compounds, aligning with the global demand for innovative treatments. The compound's nitropyridine core is a key structural motif in many bioactive molecules, making it a focal point for medicinal chemistry studies.

From an industrial perspective, 3-Bromo-6-chloro-2-methyl-5-nitropyridine is also employed in the production of high-performance materials. Its ability to undergo selective substitution reactions allows for the creation of customized derivatives tailored for specific applications. This adaptability is particularly relevant in the context of sustainable chemistry, where efficiency and precision are paramount.

Recent advancements in synthetic methodologies have further enhanced the accessibility of 3-Bromo-6-chloro-2-methyl-5-nitropyridine. Techniques such as microwave-assisted synthesis and flow chemistry have reduced reaction times and improved yields, addressing the needs of both academic and industrial researchers. These innovations are part of a broader trend toward greener and more efficient chemical processes, which resonate with current environmental and economic priorities.

In addition to its scientific significance, 3-Bromo-6-chloro-2-methyl-5-nitropyridine is frequently discussed in online forums and databases, reflecting its relevance to contemporary research. Common search queries include "synthesis of 3-Bromo-6-chloro-2-methyl-5-nitropyridine," "applications of nitropyridine derivatives," and "CAS 186413-75-2 suppliers." These trends highlight the compound's importance and the need for comprehensive, up-to-date information.

Quality control and analytical characterization are critical aspects of working with 3-Bromo-6-chloro-2-methyl-5-nitropyridine. Techniques such as HPLC, NMR, and mass spectrometry are routinely employed to ensure purity and confirm structural integrity. These measures are essential for maintaining the compound's reliability in high-stakes applications, such as pharmaceutical development.

Looking ahead, the demand for 3-Bromo-6-chloro-2-methyl-5-nitropyridine is expected to rise, driven by ongoing research into its derivatives and potential new applications. Its role in the development of next-generation chemicals underscores its enduring value to the scientific community. As innovation continues to unfold, this compound will likely remain at the forefront of cutting-edge research.

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