• 1. An intermolecular C–C coupling reaction of iridium complexes?
  Kathrin Kutlescha,Rhett Kempe New J. Chem., 2010,34, 1954-1960
• 2. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 3. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 4. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 5. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399

Introduction to 3-Amino-4-(4-bromophenyl)-1-methylpyrazole (CAS No. 1782569-25-8) and Its Emerging Applications in Chemical Biology and Medicinal Chemistry

3-Amino-4-(4-bromophenyl)-1-methylpyrazole, identified by the chemical compound identifier CAS No. 1782569-25-8, represents a significant molecule in the realm of chemical biology and medicinal chemistry. This heterocyclic compound, featuring a pyrazole core substituted with an amino group, a brominated phenyl ring, and a methyl group, has garnered considerable attention due to its structural versatility and potential pharmacological properties. The unique arrangement of these functional groups not only contributes to its distinct chemical reactivity but also opens up diverse avenues for therapeutic intervention.

The pyrazole scaffold is a privileged structure in drug discovery, known for its ability to interact with biological targets such as enzymes and receptors. The presence of the amino group at the 3-position enhances the compound's solubility and allows for further derivatization, while the 4-bromophenyl moiety introduces electrophilic centers that can participate in various chemical transformations. The methyl group at the 1-position provides steric hindrance and influences the overall electronic properties of the molecule. These structural features collectively contribute to the compound's potential as a lead candidate in developing novel therapeutic agents.

Recent advancements in computational chemistry and high-throughput screening have accelerated the identification of promising candidates like 3-Amino-4-(4-bromophenyl)-1-methylpyrazole. Studies have demonstrated that pyrazole derivatives exhibit a wide range of biological activities, including antimicrobial, anti-inflammatory, and anticancer effects. The specific substitution pattern of this compound makes it particularly interesting for investigating its interaction with biological targets. For instance, the brominated phenyl ring can serve as a handle for further functionalization via cross-coupling reactions, enabling the synthesis of more complex derivatives with tailored pharmacological profiles.

In particular, the amino group of 3-Amino-4-(4-bromophenyl)-1-methylpyrazole can be utilized to form amide or urea linkages with bioactive molecules, enhancing binding affinity and selectivity. This strategy has been successfully employed in the development of small-molecule inhibitors targeting various kinases and proteases. Additionally, the bromophenyl moiety can undergo palladium-catalyzed coupling reactions with aryl halides or alkynes, facilitating the construction of more intricate structures. Such transformations are crucial for optimizing drug-like properties such as bioavailability, metabolic stability, and cell permeability.

The compound's potential extends beyond traditional pharmaceutical applications. In agrochemical research, pyrazole derivatives have shown promise as herbicides and fungicides due to their ability to disrupt essential biological pathways in pests. The structural motifs present in 3-Amino-4-(4-bromophenyl)-1-methylpyrazole align well with this growing demand for innovative agrochemical solutions. Furthermore, its stability under various environmental conditions makes it a suitable candidate for field-tested formulations that require prolonged shelf life and efficacy.

From a synthetic chemistry perspective, 3-Amino-4-(4-bromophenyl)-1-methylpyrazole serves as a versatile building block for exploring new synthetic methodologies. The combination of functional groups allows for multiple pathways to derivatization, making it an ideal candidate for studying catalytic processes and reaction optimization. Recent literature highlights its use in generating libraries of pyrazole-based compounds through combinatorial chemistry approaches. These libraries have been screened for biological activity, leading to the discovery of novel lead compounds with improved pharmacokinetic profiles.

The development of high-resolution crystallographic techniques has further enhanced our understanding of how 3-Amino-4-(4-bromophenyl)-1-methylpyrazole interacts with biological targets at the molecular level. Structural insights obtained from such studies can guide medicinal chemists in designing next-generation analogs with enhanced binding affinity and reduced side effects. For example, knowledge gained from X-ray crystallography has been instrumental in rationalizing why certain substitutions enhance or diminish binding interactions with target proteins.

The integration of machine learning and artificial intelligence into drug discovery has also revolutionized the way researchers approach compound design. Predictive models trained on large datasets can identify optimal substitution patterns for maximizing biological activity while minimizing toxicity. These computational tools have been applied to 3-Amino-4-(4-bromophenyl)-1-methylpyrazole, suggesting promising directions for further optimization based on predicted binding affinities and physicochemical properties.

In conclusion,3-Amino-4-(4-bromophenyl)-1-methylpyrazole (CAS No. 1782569-25-8) stands out as a multifaceted compound with significant potential in chemical biology and medicinal chemistry. Its unique structural features enable diverse functionalization strategies, making it an invaluable tool for developing novel therapeutics across multiple therapeutic areas. As research continues to uncover new applications and synthetic possibilities,this molecule is poised to play an increasingly important role in advancing scientific understanding and therapeutic innovation.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)