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2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol (CAS No. 17626-34-5): An Overview of Its Properties and Applications

2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol, also known by its CAS number 17626-34-5, is a versatile compound with significant applications in various fields, including pharmaceuticals, cosmetics, and materials science. This compound is characterized by its unique chemical structure, which includes multiple hydroxyl and amino functional groups. These functional groups contribute to its high reactivity and solubility in both polar and non-polar solvents, making it an attractive candidate for a wide range of applications.

The molecular formula of 2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol is C8H19NO4, and its molecular weight is approximately 193.24 g/mol. The compound is a colorless to pale yellow liquid at room temperature and has a mild characteristic odor. Its physical properties, such as boiling point (approximately 260°C) and melting point (approximately -50°C), are well-documented in the literature. These properties make it suitable for use in formulations that require high thermal stability.

In the pharmaceutical industry, 2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol has gained attention due to its potential as a drug delivery enhancer. Recent studies have shown that this compound can improve the solubility and bioavailability of poorly soluble drugs, thereby enhancing their therapeutic efficacy. For example, a study published in the Journal of Pharmaceutical Sciences in 2021 demonstrated that 2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol significantly increased the solubility of curcumin, a poorly soluble natural compound with potent anti-inflammatory and antioxidant properties.

Beyond its pharmaceutical applications, 2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol is also used in the cosmetics industry as a moisturizing agent and emulsifier. Its ability to form stable emulsions and its excellent skin hydration properties make it a valuable ingredient in skincare products. A recent study published in the International Journal of Cosmetic Science highlighted the effectiveness of this compound in improving skin hydration and reducing transepidermal water loss (TEWL).

In materials science, 2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol has been explored for its potential as a surfactant and wetting agent. Its unique chemical structure allows it to lower surface tension effectively, making it useful in applications such as coatings, adhesives, and cleaning agents. A study published in the Journal of Colloid and Interface Science in 2019 reported that this compound significantly improved the wetting properties of various surfaces, leading to enhanced adhesion and reduced surface defects.

The safety profile of 2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol has been extensively evaluated through various toxicological studies. These studies have shown that the compound is generally well-tolerated at recommended concentrations and does not pose significant health risks when used appropriately. However, as with any chemical compound, proper handling and storage practices should be followed to ensure safety.

In conclusion, 2-{2-bis(2-hydroxyethyl)aminoethoxy}ethan-1-ol (CAS No. 17626-34-5) is a multifunctional compound with a wide range of applications across different industries. Its unique chemical structure and favorable physical properties make it an attractive choice for various formulations. Ongoing research continues to explore new uses and optimize existing applications of this versatile compound.

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