Cas no 175278-19-0 (4-Cyano-2-(trifluoromethoxy)acetanilide)

4-Cyano-2-(trifluoromethoxy)acetanilide is a specialized organic compound featuring a cyano group and a trifluoromethoxy substituent on an acetanilide backbone. Its unique structure makes it valuable in pharmaceutical and agrochemical research, particularly as an intermediate in the synthesis of bioactive molecules. The trifluoromethoxy group enhances lipophilicity and metabolic stability, while the cyano group offers reactivity for further functionalization. This compound exhibits potential utility in the development of herbicides, insecticides, and medicinal agents due to its electron-withdrawing properties and structural versatility. High purity and consistent quality ensure reliable performance in synthetic applications. Proper handling and storage under inert conditions are recommended to maintain stability.
4-Cyano-2-(trifluoromethoxy)acetanilide structure
175278-19-0 structure
Product Name:4-Cyano-2-(trifluoromethoxy)acetanilide
CAS No:175278-19-0
MF:C10H7F3N2O2
MW:244.169992685318
MDL:MFCD00204174
CID:111987
PubChem ID:2736739
Update Time:2025-10-07

4-Cyano-2-(trifluoromethoxy)acetanilide Chemical and Physical Properties

Names and Identifiers

    • N-(4-Cyano-2-(trifluoromethoxy)phenyl)acetamide
    • 4-Cyano-2-(trifluoromethoxy)acetanilide
    • Acetamide,N-[4-cyano-2-(trifluoromethoxy)phenyl]-
    • N-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide
    • N1-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide
    • 4'-Cyano-2'-(trifluoromethoxy)acetanilide
    • N-(4-cyano-2-trifluoromethoxy-phenyl)-acetamide
    • 4-ACETAMIDO-3-(TRIFLUOROMETHOXY)BENZONITRILE
    • N1-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide, 95+%
    • A881591
    • Acetamide, N-[4-cyano-2-(trifluoromethoxy)phenyl]-
    • N-(4-cyano-2-trifluoromethoxyphenyl)-acetamide
    • SCHEMBL4398648
    • AKOS022181786
    • CS-0333838
    • 175278-19-0
    • Maybridge1_000083
    • DTXSID00371565
    • FS-1070
    • MFCD00204174
    • MixCom1_000149
    • 4-cyano-2-(trifluoromethoxy)acetanilide, AldrichCPR
    • FT-0629701
    • DB-065091
    • N-[4-Cyano-2-(trifluoromethoxy)phenyl]acetamide, 4-(Acetylamino)-3-(trifluoromethoxy)benzonitrile
    • MDL： MFCD00204174
    • Inchi： 1S/C10H7F3N2O2/c1-6(16)15-8-3-2-7(5-14)4-9(8)17-10(11,12)13/h2-4H,1H3,(H,15,16)
    • InChI Key： RHBNAXXJVYFEEA-UHFFFAOYSA-N
    • SMILES： FC(OC1C=C(C#N)C=CC=1NC(C)=O)(F)F

Computed Properties

  • Exact Mass: 244.04600
  • Monoisotopic Mass: 244.04596196g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 4
  • Complexity: 334
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 3
  • XLogP3: nothing
  • Topological Polar Surface Area: 62.1?2

Experimental Properties

  • Color/Form: Not determined
  • Melting Point: 118 °C
  • PSA: 62.12000
  • LogP: 2.48828
  • Solubility: Not determined

4-Cyano-2-(trifluoromethoxy)acetanilide Security Information

  • Hazard Statement： Irritant
  • Hazard Category Code： 36/37/38-43-36-22
  • Safety Instruction： S26-S36/37/39
  • Hazardous Material Identification： Xi
  • Safety Term：S26;S36/37/39
  • Risk Phrases：R20/21/22; R36/37/38
  • HazardClass：IRRITANT

4-Cyano-2-(trifluoromethoxy)acetanilide Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI XIAN DING Biotechnology Co., Ltd.
001344-1g
4-Cyano-2-(trifluoromethoxy)acetanilide
 175278-19-0 97%
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TRC
C988268-100mg
4-Cyano-2-(trifluoromethoxy)acetanilide
 175278-19-0
100mg
 $ 50.00 2022-06-06
TRC
C988268-500mg
4-Cyano-2-(trifluoromethoxy)acetanilide
 175278-19-0
500mg
 $ 95.00 2022-06-06
TRC
C988268-1g
4-Cyano-2-(trifluoromethoxy)acetanilide
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 $ 135.00 2022-06-06

4-Cyano-2-(trifluoromethoxy)acetanilide Related Literature

Related Categories

Additional information on 4-Cyano-2-(trifluoromethoxy)acetanilide

4-Cyano-2-(trifluoromethoxy)acetanilide: A Comprehensive Overview

4-Cyano-2-(trifluoromethoxy)acetanilide (CAS No. 175278-19-0) is a highly specialized organic compound that has garnered significant attention in the fields of medicinal chemistry and materials science. This compound, characterized by its unique structure, combines a cyano group with a trifluoromethoxy substituent, making it a versatile molecule with potential applications in drug discovery and advanced materials development. Recent studies have highlighted its role in modulating biological pathways and its potential as a building block for novel pharmaceutical agents.

The synthesis of 4-Cyano-2-(trifluoromethoxy)acetanilide involves a multi-step process that leverages modern organic synthesis techniques. Researchers have employed various strategies, including nucleophilic aromatic substitution and coupling reactions, to efficiently construct this compound. The incorporation of the trifluoromethoxy group enhances the molecule's electronic properties, making it an attractive candidate for further functionalization. Recent advancements in catalytic methods have also improved the yield and purity of this compound, facilitating its use in large-scale applications.

One of the most promising aspects of 4-Cyano-2-(trifluoromethoxy)acetanilide is its pharmacological activity. Preclinical studies have demonstrated its ability to inhibit key enzymes involved in inflammatory pathways, suggesting its potential as an anti-inflammatory agent. Additionally, this compound has shown selectivity towards certain receptor subtypes, which could be exploited for the development of targeted therapies. The cyano group plays a critical role in modulating these activities, underscoring the importance of structural diversity in drug design.

In terms of material science applications, 4-Cyano-2-(trifluoromethoxy)acetanilide has been investigated for its role in the synthesis of advanced polymers and coatings. Its ability to form stable cross-links under specific conditions makes it a valuable precursor for high-performance materials. Recent research has focused on optimizing polymerization conditions to enhance the mechanical and thermal properties of materials derived from this compound.

The environmental impact of 4-Cyano-2-(trifluoromethoxy)acetanilide has also been a topic of interest. Studies have shown that this compound exhibits low toxicity to aquatic organisms under standard laboratory conditions. However, further research is needed to assess its long-term effects on ecosystems and to develop sustainable methods for its production and disposal.

In conclusion, 4-Cyano-2-(trifluoromethoxy)acetanilide (CAS No. 175278-19-0) represents a significant advancement in organic chemistry with diverse applications across multiple disciplines. Its unique structure, combined with recent breakthroughs in synthesis and application development, positions it as a key molecule for future innovations in medicine and materials science.

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