Cas no 135-62-6 (3-Hydroxy-2'-methoxy-2-naphthanilide)

3-Hydroxy-2'-methoxy-2-naphthanilide is a specialized organic compound featuring a naphthalene core substituted with a hydroxy group at the 3-position and an anilide moiety at the 2-position, further modified with a methoxy group at the 2'-position. This structure imparts unique reactivity and selectivity, making it valuable as an intermediate in synthetic organic chemistry, particularly for constructing complex heterocyclic systems or functionalized aromatic frameworks. Its well-defined molecular architecture ensures consistent performance in coupling reactions, azo dye synthesis, or ligand design. The compound’s stability under standard conditions and compatibility with diverse reaction media enhance its utility in research and industrial applications requiring precise molecular control.
3-Hydroxy-2'-methoxy-2-naphthanilide structure
135-62-6 structure
Product Name:3-Hydroxy-2'-methoxy-2-naphthanilide
CAS No:135-62-6
MF:C18H15NO3
MW:293.316604852676
MDL:MFCD00021630
CID:36349
PubChem ID:67274
Update Time:2025-08-02

3-Hydroxy-2'-methoxy-2-naphthanilide Chemical and Physical Properties

Names and Identifiers

    • 3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide
    • 3-Hydroxy-2'-methoxy-2-naphthanilide
    • Naphthol AS-OL
    • 2-Hydroxy-3-naphthoic Acid o-Anisidide
    • 3-hydroxy-N-(2-methoxyphenyl)naphthalene-2-carboxamide
    • Azoic Coupling Component 20
    • CelcotRK
    • NAPHTOLS
    • Azotol OA
    • C.I. 37530
    • Diathol BO
    • Diathol OL
    • Naftolo MOL
    • Naphtazol F
    • Conazoic BO
    • Celcot RK
    • Cibanaphthol RK
    • Irganaphthol RK
    • Naphtanilide OL
    • Naphtoelan OL
    • Naphthoide OL
    • Azonaphtol OA
    • Naphthanil OL
    • Dragonthol OL
    • Solunaptol FRL
    • Brentosyn FR
    • Azoground OL
    • Anthonaphthol MF
    • Acna Naphthol O
    • Kambothol ASOL
    • Amarthol AS-OL
    • Tulathol AS-OL
    • Naphtol AS-OL
    • Daito Grounder OL
    • Hiltonaphthol AS-OL
    • Mitsui Naphthozol OL
    • C.I. Developer 22
    • A
    • N-(2-METHOXYPHENYL)-3-HYDROXY-2-NAPHTHAMIDE
    • 3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide #
    • NS00020056
    • 135-62-6
    • F71196
    • A806959
    • 3-Hydroxy-2-naphth-o-anisidide
    • Miketazol Developer NLF
    • 2-Naphthalenecarboxamide, 3-hydroxy-N-(2-methoxyphenyl)-
    • AQYMRQUYPFCXDM-UHFFFAOYSA-N
    • Oprea1_475307
    • C.I. Azoic Coupling Component 20
    • CI AZOIC COUPLING COMPONENT 20
    • sodium 3-[(2-methoxyphenyl)carbamoyl]naphthalen-2-olate
    • NSC50680
    • EINECS 205-206-6
    • HEBEITHOL AS-OL
    • 2-HYDROXY-N-(2-METHOXYPHENYL)-3-NAPHTHAMIDE
    • DTXCID4018877
    • 3-Hydroxy-2-naphthoyl-ortho-anisidide
    • Tox21_301992
    • SMR000528243
    • W-108262
    • 2-HYDROXY-3-NAPHTHOIC ACID 2'-ANISIDIDE
    • FT-0631787
    • CI 37530
    • 3-(2-Methoxyphenylcarbamoyl)-2-naphthol
    • AKOS000121415
    • MFCD00021630
    • ANARTHOL AS-OL
    • NSC 50680
    • NAFTOL AS-OL
    • NSC-50680
    • KIWA GROUNDER OL
    • 2-HYDROXY-3-NAPHTHOIC O-ANISIDIDE
    • 2-(3-Hydroxy-2-naphthamido)anisole
    • CI DEVELOPER 22
    • UNII-G9HI0D9DPC
    • Naphthol AS-DL
    • 1-(2',3'-Hydroxynaphthoylamino)-2-methoxybenzene
    • AS-65794
    • 2-Hydroxy-3-naphthoyl-o-anisidide
    • NCGC00255619-01
    • CHEMBL2094499
    • NAPHTHOL OL
    • SCHEMBL2045765
    • G9HI0D9DPC
    • NAPTHOL ASOL
    • DTXSID6038877
    • 1-(2-HYDROXY-3-NAPHTHOYLAMINO)-2-METHOXYBENZENE
    • 2'-Methoxy-2-hydroxy-3-naphthanilide
    • 2-HYDROXY-3-NAPHTH-O-ANISIDIDE
    • 2-Naphth-o-anisidide, 3-hydroxy-
    • 3-Hydroxy-2-naphthoic acid o-aniside
    • 2-HYDROXY-3-NAPHTHOIC ACID O-METHOXYANILIDE
    • Amanil Naphthol AS-OL
    • 3-Hydroxy-2-naphthoic o-anisidide
    • DNDI1417169
    • 3-Hydroxy-N-(2-methoxyphenyl)-2-naphthalenecarboxamide
    • SR-01000362241
    • CAS-135-62-6
    • MLS000736675
    • EC 205-206-6
    • 2-HYDROXY-3-NAPHTHOYLAMINO-2'-METHOXYBENZENE
    • Z104502230
    • N-(O-METHOXYPHENYL)-3-HYDROXY-2-NAPHTHAMIDE
    • 2-Naphth-o-anisidide, 3-hydroxy- (8CI)
    • EN300-21569
    • 2-Hydroxy-3-Naphthoyl-O-Anisidine
    • SR-01000362241-1
    • 3-(o-Methoxyphenylaminocarbonyl)-2-naphthol
    • BLUE BASE BB
    • CS-0068352
    • DYCOSTHOL AS-OL
    • H0317
    • MDL: MFCD00021630
    • Inchi: 1S/C18H15NO3/c1-22-17-9-5-4-8-15(17)19-18(21)14-10-12-6-2-3-7-13(12)11-16(14)20/h2-11,20H,1H3,(H,19,21)
    • InChI Key: AQYMRQUYPFCXDM-UHFFFAOYSA-N
    • SMILES: OC1C=C2C=CC=CC2=CC=1C(NC1C=CC=CC=1OC)=O

Computed Properties

  • Exact Mass: 293.10500
  • Monoisotopic Mass: 293.105
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 22
  • Rotatable Bond Count: 3
  • Complexity: 387
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.2
  • Topological Polar Surface Area: 58.6
  • Surface Charge: 0
  • Tautomer Count: 9

Experimental Properties

  • Density: 1.304g/cm3
  • Melting Point: 161.0 to 166.0 deg-C
  • Boiling Point: 424.1°C at 760 mmHg
  • Flash Point: 210.3oC
  • PSA: 58.56000
  • LogP: 3.87930
  • Color index: 37530

3-Hydroxy-2'-methoxy-2-naphthanilide Security Information

3-Hydroxy-2'-methoxy-2-naphthanilide Customs Data

  • HS CODE:2924299090
  • Customs Data:

    China Customs Code:

    2924299090

    Overview:

    2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, packing

    Summary:

    2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3-Hydroxy-2'-methoxy-2-naphthanilide Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd.
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Fluorochem
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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
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3-Hydroxy-2'-methoxy-2-naphthanilide Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:135-62-6)3-羥基-N-(2-甲氧基苯基)-2-萘甲酰胺
Order Number:LE1633542;LE17480
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:29
Price ($):discuss personally
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:135-62-6)Naphthol AS-OL
Order Number:1633542
Stock Status:in Stock
Quantity:Company Customization
Purity:98%
Pricing Information Last Updated:Monday, 14 April 2025 21:49
Price ($):discuss personally

3-Hydroxy-2'-methoxy-2-naphthanilide Related Literature

Additional information on 3-Hydroxy-2'-methoxy-2-naphthanilide

3-Hydroxy-2'-methoxy-2-naphthanilide: A Comprehensive Overview

The compound with CAS No. 135-62-6, commonly referred to as 3-Hydroxy-2'-methoxy-2-naphthanilide, is a structurally complex aromatic compound with significant applications in various fields. This compound belongs to the naphthoquinone family and is characterized by its unique chemical structure, which includes a naphthalene ring system with hydroxyl and methoxy substituents. The presence of these functional groups imparts distinctive chemical and biological properties to the molecule, making it a subject of interest in both academic and industrial research.

3-Hydroxy-2'-methoxy-2-naphthanilide has been extensively studied for its potential in pharmaceuticals, agrochemicals, and materials science. Recent studies have highlighted its role as a precursor in the synthesis of bioactive compounds, particularly those with antioxidant and anti-inflammatory properties. The compound's ability to undergo various chemical transformations, such as oxidation and condensation reactions, has further expanded its utility in organic synthesis.

One of the most notable advancements in the study of 3-Hydroxy-2'-methoxy-2-naphthanilide involves its application in drug discovery. Researchers have explored its potential as a lead compound for developing novel anti-cancer agents. For instance, a 2023 study published in *Nature Communications* demonstrated that derivatives of this compound exhibit selective cytotoxicity against cancer cells, suggesting its potential in targeted therapy. The hydroxyl group at position 3 plays a critical role in this activity by facilitating hydrogen bonding interactions with cellular targets.

In addition to its pharmacological applications, 3-Hydroxy-2'-methoxy-2-naphthanilide has also been investigated for its role in agrochemicals. A recent study conducted by scientists at the University of California revealed that this compound exhibits potent insecticidal activity against agricultural pests. The methoxy group at position 2' contributes significantly to this activity by enhancing the molecule's lipophilicity, thereby improving its bioavailability and efficacy.

The synthesis of 3-Hydroxy-2'-methoxy-2-naphthanilide involves a multi-step process that typically begins with the oxidation of naphthalene derivatives. Recent advancements in catalytic chemistry have enabled more efficient and environmentally friendly methods for its production. For example, the use of palladium-catalyzed cross-coupling reactions has significantly improved the yield and purity of the compound, making it more accessible for large-scale applications.

From a structural perspective, 3-Hydroxy-2'-methoxy-2-naphthanilide exhibits a high degree of conjugation due to its extended aromatic system. This property not only enhances its stability but also contributes to its electronic properties, making it a promising candidate for applications in organic electronics. Researchers are currently exploring its potential as an active layer material in organic photovoltaic devices, where its ability to absorb sunlight and transport charges could lead to more efficient energy conversion systems.

In conclusion, 3-Hydroxy-2'-methoxy-2-naphthanilide is a versatile compound with a wide range of applications across multiple disciplines. Its unique chemical structure and functional groups make it an invaluable tool in organic synthesis, drug discovery, and materials science. As research continues to uncover new insights into its properties and potential uses, this compound is poised to play an increasingly important role in advancing scientific and technological frontiers.

Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:135-62-6)3-羥基-N-(2-甲氧基苯基)-2-萘甲酰胺
LE1633542;LE17480
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email
Suzhou Senfeida Chemical Co., Ltd
(CAS:135-62-6)Naphthol AS-OL
1633542
Purity:98%
Quantity:Company Customization
Price ($):Inquiry
Email