• 1. Enantioselective total synthesis of plakotenin, a cytotoxic metabolite from Plakortis sp
  Stephanie Arzt,Emmanuel Bourcet,Thierry Muller,Stefan Br?se Org. Biomol. Chem. 2010 8 3300
• 2. Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators
  R. Bl?cher,C. Lamers,S. K. Wittmann,O. Diehl,T. Hanke,D. Merk,D. Steinhilber,M. Schubert-Zsilavecz,A. S. Kahnt,E. Proschak Med. Chem. Commun. 2016 7 1209

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid esters

Triethyl 2-phosphonobutyrate (CAS No. 17145-91-4): A Versatile Phosphonate Compound in Modern Chemical and Pharmaceutical Research

Triethyl 2-phosphonobutyrate, chemically identified by the CAS number 17145-91-4, is a significant compound in the realm of organic chemistry and pharmaceutical applications. This phosphonate derivative, characterized by its ethyl ester groups and a phosphonic acid backbone, has garnered considerable attention due to its diverse utility in synthetic chemistry, drug development, and material science. The compound's unique structural features make it a valuable intermediate in the synthesis of more complex molecules, particularly in the context of bioactive compounds and functional materials.

The molecular structure of Triethyl 2-phosphonobutyrate consists of a butyl chain terminated by a phosphonic acid group, which is further modified by three ethyl ester units. This configuration imparts a high degree of reactivity, enabling the compound to participate in various chemical transformations. The presence of the phosphonate group enhances its solubility in polar solvents and facilitates its incorporation into larger molecular frameworks. These properties have made it a staple in research laboratories focusing on novel drug candidates and advanced material formulations.

In recent years, Triethyl 2-phosphonobutyrate has been explored for its potential applications in pharmaceutical research. Its ability to act as a precursor for more complex phosphonate-containing molecules has opened new avenues in the development of therapeutic agents. For instance, phosphonate-based compounds have shown promise in the treatment of bone diseases, metal chelation therapy, and as inhibitors of enzymes involved in pathogenic processes. The versatility of this compound allows researchers to design derivatives with tailored properties, enhancing their efficacy and selectivity.

The synthesis of Triethyl 2-phosphonobutyrate typically involves the reaction of diethyl phosphonoacetate with butanol under controlled conditions. This process highlights the compound's role as a building block in organic synthesis. The reaction conditions can be optimized to achieve high yields and purity, making it a reliable choice for industrial-scale production. Furthermore, advancements in catalytic methods have improved the efficiency of its synthesis, reducing the environmental impact and cost associated with its production.

One of the most compelling aspects of Triethyl 2-phosphonobutyrate is its application in materials science. Phosphonate derivatives are known for their ability to form stable complexes with metals, making them useful in corrosion inhibition and water treatment technologies. Additionally, these compounds have been investigated for their potential use in nanotechnology, where they can serve as ligands or stabilizers for metal nanoparticles. The ability to functionalize the phosphonate group with various substituents allows for the creation of materials with specific properties, such as enhanced biocompatibility or improved thermal stability.

The pharmaceutical industry has also leveraged Triethyl 2-phosphonobutyrate for developing novel drug formulations. Its incorporation into drug molecules can improve pharmacokinetic properties such as solubility and bioavailability. For example, studies have demonstrated its role in enhancing the absorption and distribution of certain therapeutic agents when used as part of a prodrug strategy. This approach has been particularly useful in treating metabolic disorders where targeted delivery is crucial.

In conclusion, Triethyl 2-phosphonobutyrate (CAS No. 17145-91-4) is a multifaceted compound with broad applications across chemical synthesis and pharmaceutical research. Its unique structural features enable it to serve as an effective intermediate in the development of bioactive molecules and advanced materials. As research continues to uncover new applications for this compound, its significance is expected to grow further, solidifying its place as a cornerstone in modern chemical innovation.

• 35051-49-1(Ethyl 2-Diethoxyphosphorylpentanoate)
• 2907-85-9(Phosphonic acid,P-(tetrahydro-2-oxo-3-furanyl)-, diethyl ester)
• 10140-81-5(Butanedioic acid,2-(dibutoxyphosphinyl)-, 1,4-dibutyl ester)
• 6316-12-7(Hexanoic acid,2-[bis(hexyloxy)phosphinyl]-, hexyl ester)
• 6975-35-5(Dodecanoic acid,2-(dibutoxyphosphinyl)-, ethyl ester)
• 66324-59-2(Pentanedioic acid,2-(diethoxyphosphinyl)-, 1,5-diethyl ester)
• 6340-09-6(Octanoicacid, 2-[bis(hexyloxy)phosphinyl]-, butyl ester)
• 14581-03-4(Dodecanoic acid,2-(diethoxyphosphinyl)-, ethyl ester)
• 4762-67-8(Butanedioicacid, 2-(dibutoxyphosphinyl)-, 1,4-diethyl ester)
• 6295-62-1(Dodecanoic acid,2-(diethoxyphosphinyl)-, butyl ester)