Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators?
MedChemComm Pub Date: 2016-04-22 DOI: 10.1039/C6MD00042H
Abstract
Metabolic syndrome (MetS) is a widespread, complex disease cluster which consists of hypertension, atherosclerosis, dyslipidaemia and type II diabetes. The treatment of MetS requires multiple pharmaceutical agents leading to complex polypharmacy. Multi-target compounds might reduce the number of required drugs in MetS patients. In this study we fused three different pharmacophores of soluble epoxide hydrolase (sEH) inhibitors and peroxisome proliferator-activated receptor (PPAR) agonists. The most promising fused scaffold exhibits multi-target activity and represents a valuable starting point for design and evaluation of fused sEH/PPAR modulators.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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