Production Method 1

24424-99-5

56-84-8

170943-10-9

Reaction Conditions

1.1R:AcCl, 15 min, rt
1.21 h, rt; 23 h, rt
2.1R:Et3N, S:H2O, S:Dioxane, 3 h, rt
2.2R:Citric acid, S:H2O, rt, pH 4-5
3.1R:K2CO3, S:DMF, 2 h, rt
3.212 h, rt

Reference

The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate

By Sato, Kohei et al, Chemical Communications (Cambridge, 2015, 51(49), 9946-9948

Production Method 2

24424-99-5

56-84-8

170943-10-9

Reaction Conditions

1.1R:AcCl, S:CH2=CHCH2OH, 0°C; 15 min, 0°C; 1 h, rt
1.218 h, rt; rt → 0°C
1.3S:Et2O, 1 h, 0°C
2.1R:Et3N, S:H2O, S:Dioxane, rt; 22 h, rt
2.2R:Citric acid, S:H2O, 0°C, pH 3
3.1R:K2CO3, S:DMF, 30 s, 0°C; 24 h, 0°C
3.2S:H2O, 0°C

Reference

Thiazolidine-Protected β-Thiol Asparagine: Applications in One-Pot Ligation-Desulfurization Chemistry

By Sayers, Jessica et al, Organic Letters, 2015, 17(19), 4902-4905

L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methyl 4-(2-propen-1-yl) ester Raw materials

• Di-tert-butyl dicarbonate
• L-Aspartic acid

L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methyl 4-(2-propen-1-yl) ester Preparation Products

• L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methyl 4-(2-propen-1-yl) ester (170943-10-9)

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