• 1. A CoII complex for 19F MRI-based detection of reactive oxygen species
  Meng Yu,Da Xie,Khanh P. Phan,José S. Enriquez,Jeffrey J. Luci,Emily L. Que Chem. Commun. 2016 52 13885

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives Carboxylic acid amides

Introduction to 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide (CAS No. 170655-44-4)

2-Chloro-N-(2,2,2-trifluoroethyl)acetamide, identified by the Chemical Abstracts Service Number (CAS No.) 170655-44-4, is a fluorinated amide derivative that has garnered significant attention in the field of pharmaceutical chemistry and medicinal research. This compound belongs to a class of molecules characterized by the presence of both chloro and trifluoroethyl substituents, which contribute to its unique physicochemical properties and potential biological activities. The structural features of this compound make it a valuable intermediate in the synthesis of various pharmacologically relevant molecules, particularly in the development of novel therapeutic agents.

The molecular structure of 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide consists of an acetamide backbone substituted with a chloro group at the α-carbon and a 2,2,2-trifluoroethyl group at the β-carbon. This specific arrangement imparts both lipophilicity and electronic effects that are critical for modulating biological interactions. The presence of the trifluoroethyl group, in particular, has been extensively studied for its ability to enhance metabolic stability and binding affinity in drug candidates. This feature is particularly relevant in the context of modern drug design, where optimizing pharmacokinetic profiles is essential for achieving therapeutic efficacy.

In recent years, there has been a surge in research focused on fluorinated compounds due to their tunable electronic properties and improved pharmacological profiles. Fluorine atoms are known to influence the bioavailability, metabolic stability, and binding interactions of drug molecules. The incorporation of fluorine into pharmaceuticals has led to the development of several blockbuster drugs that exhibit enhanced potency and reduced toxicity compared to their non-fluorinated counterparts. 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide exemplifies this trend, as its structure incorporates both fluorine and chlorine atoms in a manner that could potentially enhance its biological activity.

One of the most compelling aspects of 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide is its potential as a building block for more complex pharmacophores. The chloro and trifluoroethyl groups provide reactive sites that can be further functionalized through various chemical transformations. For instance, nucleophilic substitution reactions at the chloro moiety can introduce diverse substituents, while the trifluoroethyl group can serve as a scaffold for further derivatization. These properties make it a versatile intermediate in synthetic chemistry.

The pharmaceutical industry has shown particular interest in amide derivatives due to their broad spectrum of biological activities. Amides are known to exhibit properties such as analgesic, anti-inflammatory, and antimicrobial effects. The structural motif present in cas no170655-44-4 could potentially be leveraged to develop novel therapeutics targeting various disease pathways. For example, modifications to the amide bond or the substituents attached to it could alter its pharmacological profile significantly.

In academic research circles, cas no170655-44-4 has been explored as a precursor in the synthesis of more complex molecules with potential therapeutic applications. Recent studies have demonstrated its utility in generating libraries of fluorinated amides for high-throughput screening (HTS). These libraries are used to identify lead compounds with desirable biological activities against targets such as kinases, proteases, and other enzymes involved in disease mechanisms.

The synthesis of cas no170655-44-4 typically involves multi-step organic reactions that require careful optimization to achieve high yields and purity. Common synthetic routes include chlorination followed by nucleophilic substitution with 2-chloroacetonitrile or other suitable reagents. The introduction of the trifluoroethyl group often involves halogen-metal exchange or other organometallic transformations that highlight the compound's synthetic versatility.

The physicochemical properties of cas no170655-44-4, including solubility and melting point, are influenced by its fluorinated structure. These properties are critical for determining its suitability for various applications, such as formulation development or use in solid-state pharmaceuticals. For instance, fluorinated compounds often exhibit improved solubility in organic solvents compared to their non-fluorinated analogs.

The safety profile of cas no170655-44-4 is another important consideration in its application within pharmaceutical research. While preliminary studies suggest that it behaves as an expected organic intermediate under standard laboratory conditions, further characterization is necessary to fully understand its toxicological implications. This includes assessing potential effects on human health and environmental impact following prolonged exposure.

In conclusion,cas no170655-44-4, also known as 1-Chloro-N-(1-chloroethyl)-1H-pyrrole-3-carboxamidine hydrochloride, represents an exciting opportunity for researchers seeking novel pharmacological entities or synthetic intermediates. It embodies many qualities sought after by medicinal chemists today: structural complexity, functional diversity, potential bioactivity, synthetic accessibility. As our understanding deepens, it will be interesting to see how this molecule continues to contribute towards advancing therapeutic strategies across multiple disciplines.

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