• 1. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 2. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 3. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 4. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl cyanides

2,3-Difluoro-5-methoxy-4-methylphenylacetonitrile (CAS No. 1706461-19-9): A Comprehensive Overview

2,3-Difluoro-5-methoxy-4-methylphenylacetonitrile (CAS No. 1706461-19-9) is a specialized organic compound that has garnered significant attention in the fields of pharmaceutical research, agrochemical development, and material science. This fluorinated aromatic nitrile derivative is characterized by its unique molecular structure, which combines a methoxy group, methyl substitution, and difluoro modification on the phenyl ring. The strategic placement of these functional groups makes it a valuable intermediate for synthesizing more complex molecules with tailored properties.

The growing interest in fluorinated compounds like 2,3-Difluoro-5-methoxy-4-methylphenylacetonitrile stems from their enhanced stability, bioavailability, and lipophilicity compared to their non-fluorinated counterparts. Researchers are particularly intrigued by how the difluoro substitution pattern influences electronic distribution and steric effects, which can dramatically alter reactivity in subsequent chemical transformations. Recent studies highlight its potential as a building block for pharmaceutical intermediates, where the introduction of fluorine atoms often improves metabolic stability and membrane permeability.

In the context of current industry trends, this compound aligns with several hot topics in chemistry: green synthesis methodologies, late-stage fluorination techniques, and structure-activity relationship optimization. The presence of both electron-donating (methoxy group) and electron-withdrawing (cyano group) substituents creates interesting electronic properties that researchers are exploring for various applications. Its molecular weight of 197.17 g/mol and precise chemical structure make it particularly suitable for controlled reactions in medicinal chemistry programs.

The synthesis of 2,3-Difluoro-5-methoxy-4-methylphenylacetonitrile typically involves multi-step organic transformations starting from appropriately substituted benzene derivatives. Modern approaches emphasize atom economy and catalytic processes to improve yield and reduce environmental impact. Analytical characterization using techniques like NMR spectroscopy, mass spectrometry, and HPLC purity analysis confirms the structural integrity of this compound, which is commercially available as a high-purity material for research purposes.

From a market perspective, demand for fluorinated aromatic compounds continues to rise, driven by pharmaceutical industry needs for novel bioactive molecules. The 2,3-difluoro substitution pattern in particular has shown promise in developing compounds with improved target binding affinity. This specific phenylacetonitrile derivative offers synthetic chemists a versatile platform for further functionalization, whether through nucleophilic substitution at the cyano group or electrophilic aromatic substitution on the activated ring system.

Storage and handling of 2,3-Difluoro-5-methoxy-4-methylphenylacetonitrile require standard laboratory precautions for organic compounds. While not classified as hazardous under normal conditions, it should be kept in a cool, dry environment protected from light to maintain stability. Researchers appreciate its relatively good shelf life when properly stored, making it a practical choice for various chemical synthesis projects.

The future research directions for this compound likely involve exploring its utility in catalyzed cross-coupling reactions, investigating its potential as a precursor for heterocyclic compounds, and developing more efficient synthetic routes. Its structural features make it particularly interesting for creating libraries of analogs in drug discovery programs, where small modifications can lead to significant changes in biological activity. The presence of both fluorine atoms and a methoxy group offers multiple vectors for molecular interactions with biological targets.

For analytical chemists, 2,3-Difluoro-5-methoxy-4-methylphenylacetonitrile presents interesting challenges and opportunities in method development. The fluorine NMR signals provide distinct markers for reaction monitoring, while the aromatic proton environment offers diagnostic patterns for structural confirmation. These characteristics make it a useful reference compound for developing new analytical techniques in fluorine-containing molecule analysis.

In material science applications, the polar nature of this compound, resulting from its cyano group and methoxy substituent, suggests potential utility in designing specialty polymers or liquid crystal materials. The fluorine atoms may contribute to desired properties like thermal stability or optical characteristics, though these applications remain largely unexplored for this specific derivative.

As research into fluorine chemistry continues to expand, compounds like 2,3-Difluoro-5-methoxy-4-methylphenylacetonitrile will undoubtedly play increasingly important roles. Their ability to serve as versatile intermediates in the synthesis of more complex molecules positions them as valuable tools in both academic and industrial settings. The unique combination of substituents in this particular compound offers synthetic chemists multiple handles for creative molecular design across various fields of chemical research.

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