Cas no 170080-13-4 (D-4,4'-Biphenylalanine)

D-4,4'-Biphenylalanine is a non-natural amino acid derivative featuring a biphenyl moiety, which enhances its structural rigidity and aromatic character. This compound is particularly valuable in peptide synthesis and medicinal chemistry, where its unique conformation contributes to improved binding affinity and stability in target interactions. The D-configuration offers resistance to enzymatic degradation, making it suitable for applications requiring prolonged biological activity. Its biphenyl group facilitates π-π stacking interactions, which are critical for molecular recognition in drug design. The compound is commonly employed in the development of peptidomimetics, enzyme inhibitors, and bioactive probes, offering researchers a versatile building block for advanced biochemical studies.

D-4,4'-Biphenylalanine structure

Product Name:D-4,4'-Biphenylalanine

CAS No:170080-13-4

MF:C₁₅H₁₅NO₂

MW:241.285104036331

MDL:MFCD01318879

CID:65851

PubChem ID:7006711

Update Time:2025-06-07

D-4,4'-Biphenylalanine Chemical and Physical Properties

Names and Identifiers

- (R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid
- 4-Phenyl-D-phenyalanine
- D-4,4'-Biphenylphenylalanine
- (R)-2-Amino-3-(biphenyl-4-yl)propanoic acid
- (R)-2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID
- 3-(4-Biphenylyl)-D-alanine
- D-4,4’-Biphenylalanine
- D-4,4'-BIPHENYLALANINE
- H-4-Phenyl-D-Phe-OH
- H-D-Bip-OH
- (2R)-2-amino-3-(4-phenylphenyl)propanoic acid
- H-D-4,4'-BIPHE-OH
- 3-(4,4'-BIPHENYL)-D-ALANINE
- H-D-BPH-OH
- H-R-Bip-OH
- D-Bip(4,4')-OH
- D-4,4’-Biphe-OH
- H-D-BIP(4,4')-OH
- 4'-BIPHENYL-D-ALA
- D-BIPHENYLALANINE
- D-4-Phenyl-Phe-OH
- D-P-BIPHENYLALANINE
- D-4,4'-Biphenylalanine
- MDL： MFCD01318879
- Inchi： 1S/C15H15NO2/c16-14(15(17)18)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,14H,10,16H2,(H,17,18)/t14-/m1/s1
- InChI Key： JCZLABDVDPYLRZ-CQSZACIVSA-N
- SMILES： OC([C@@H](CC1C=CC(C2C=CC=CC=2)=CC=1)N)=O

Computed Properties

Exact Mass: 241.11000
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 18
Rotatable Bond Count: 4

Experimental Properties

Boiling Point: 428.6°C at 760 mmHg
Water Partition Coefficient: Slightly soluble in water.
PSA: 63.32000
LogP: 3.00830

D-4,4'-Biphenylalanine Security Information

Hazard Statement： H315-H319-H335
Hazardous Material Identification：

D-4,4'-Biphenylalanine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Fluorochem	228183-250mg	R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid	170080-13-4	95%	250mg	￡16.00	2022-02-28
Fluorochem	228183-1g	R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid	170080-13-4	95%	1g	￡31.00	2022-02-28
Fluorochem	228183-5g	R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid	170080-13-4	95%	5g	￡103.00	2022-02-28
SHANG HAI SHAO YUAN SHI JI Co., Ltd.	SY036178-5g	3-(4-Biphenylyl)-D-alanine	170080-13-4	≥97%	5g	￥485.00	2025-04-17
TRC	B397785-100mg	D-4,4'-Biphenylalanine	170080-13-4		100mg	$ 50.00	2022-06-07
TRC	B397785-250mg	D-4,4'-Biphenylalanine	170080-13-4		250mg	$ 90.00	2022-06-07
TRC	B397785-500mg	D-4,4'-Biphenylalanine	170080-13-4		500mg	$ 87.00	2023-04-18
TRC	B397785-1g	D-4,4'-Biphenylalanine	170080-13-4		1g	$ 211.00	2023-04-18
ChemScence	CS-M2870-5g	D-Biphenylalanine	170080-13-4		5g	$135.0	2022-04-27
ChemScence	CS-M2870-25g	D-Biphenylalanine	170080-13-4		25g	$472.0	2022-04-27

D-4,4'-Biphenylalanine Production Method

Production Method 1

63024-50-0

170080-13-4

88241-65-0

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
2.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
2.2 Solvents: Methanol ; 30 °C

Reference

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

Production Method 2

3218-36-8

170080-13-4

88241-65-0

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ; rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2 - 3, rt
2.1 Reagents: N-Bromosuccinimide , Triphenylphosphine Solvents: Dichloromethane ; 30 min, rt
3.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 30 min, rt
3.2 Solvents: Dimethylformamide ; 0 °C; 3 h, rt; 4 h, 60 °C
4.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 4 - 6 h, reflux
4.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, -10 °C
4.3 Solvents: Toluene ; 16 - 24 h, reflux
5.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
6.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
6.2 Solvents: Methanol ; 30 °C

Reference

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

Production Method 3

76985-08-5

170080-13-4

88241-65-0

Reaction Conditions

1.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
1.2 Solvents: Methanol ; 30 °C

Reference

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

Production Method 4

63024-21-5

170080-13-4

88241-65-0

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 4 - 6 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, -10 °C
1.3 Solvents: Toluene ; 16 - 24 h, reflux
2.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
3.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
3.2 Solvents: Methanol ; 30 °C

Reference

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

Production Method 5

2567-29-5

1068-90-2

170080-13-4

88241-65-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 30 min, rt
1.2 Solvents: Dimethylformamide ; 0 °C; 3 h, rt; 4 h, 60 °C
2.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 4 - 6 h, reflux
2.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, -10 °C
2.3 Solvents: Toluene ; 16 - 24 h, reflux
3.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
4.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
4.2 Solvents: Methanol ; 30 °C

Reference

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

Production Method 6

3597-91-9

170080-13-4

88241-65-0

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide , Triphenylphosphine Solvents: Dichloromethane ; 30 min, rt
2.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 30 min, rt
2.2 Solvents: Dimethylformamide ; 0 °C; 3 h, rt; 4 h, 60 °C
3.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 4 - 6 h, reflux
3.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, -10 °C
3.3 Solvents: Toluene ; 16 - 24 h, reflux
4.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
5.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
5.2 Solvents: Methanol ; 30 °C

Reference

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

D-4,4'-Biphenylalanine Raw materials

D-4,4'-Biphenylalanine Preparation Products

D-4,4'-Biphenylalanine Related Literature

1. An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems

RabailGul,MariamMir,MurtazaNAli
2. An apparatus for determining small amounts of alchohol in sour milk and urine

Analyst, 1964,89, 272-275
3. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?

Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
4. An apparatus for testing water by measurement of its electrical conductivity

Analyst, 1912,37, 538-543
5. Aggregated-fluorescent detection of PFAS with a simple chip

Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170

Related Categories

170080-13-4 (D-4,4'-Biphenylalanine) Related Products

Recommended suppliers

HANGZHOU BAIS CHEMICAL TECHNOLOGY CO., LTD.

Gold Member

Audited Supplier

CN Supplier

Reagent

HANGZHOU BAIS CHEMICAL TECHNOLOGY CO., LTD.

Shenzhen Jianxing Pharmaceutical Technology Co., Ltd.

Gold Member

Audited Supplier

CN Supplier

Reagent

Shenzhen Jianxing Pharmaceutical Technology Co., Ltd.

Jiangxi Boyang Pharmaceutical Chemical Co., Ltd

Gold Member

Audited Supplier

CN Supplier

Bulk

Jiangxi Boyang Pharmaceutical Chemical Co., Ltd

Yunnanjiuzhen

Gold Member

Audited Supplier

CN Supplier

Bulk

Shanghai Pearlk Chemicals Co., Ltd.

Gold Member

Audited Supplier

CN Supplier

Bulk

国产一区二区制服丝袜_一级特黄高清完整大片_欧美.亚洲.日韩.另类.av_黄又色又污又爽又高潮动态图_91夫妻视频电影观看_在线手机亚洲中文字幕_国产中文字幕不卡在线_国产乱妇乱子在线播视频播放网站_gogo裸体艺术中国日本

Cas no 170080-13-4 (D-4,4'-Biphenylalanine)

D-4,4'-Biphenylalanine Chemical and Physical Properties

Names and Identifiers

Computed Properties

Experimental Properties

D-4,4'-Biphenylalanine Security Information

D-4,4'-Biphenylalanine Pricemore >>

D-4,4'-Biphenylalanine Production Method

Production Method 1

Production Method 2

Production Method 3

Production Method 4

Production Method 5

Production Method 6

D-4,4'-Biphenylalanine Raw materials

D-4,4'-Biphenylalanine Preparation Products

D-4,4'-Biphenylalanine Related Literature

Related Categories

170080-13-4 (D-4,4'-Biphenylalanine) Related Products