• 1. A prototype solid phase synthesis of pteridines and related heterocyclic compounds
  Colin L. Gibson,Salvatore La Rosa,Colin J. Suckling Org. Biomol. Chem. 2003 1 1909
• 2. Notes
  D. W. Ockenden,K. Schofield,Walter Freund,Alfred Komzak,S. A. Faseeh,H. J. Callomon,H. W. Thompson,F. Allan Andersen,B?rge Bak,D. E. A. Rivett,K. T. Potts,W. H. T. Davison,A. G. Sharpe,Richard O. Whipple,Robert West,Kenneth Emerson,Alexander Mackie,A. Anthony Cutler,V. M. Ingram,Douglas Lloyd,Frederick Rowe,E. R. H. Jones,J. D. Bu'Lock,Phyllis D. Landauer,H. N. Rydon,L. N. Owen,S. P. Whitelaw,Vincent C. Barry,P. W. D. Mitchell,D. B. Cowell,W. H. Linnell,D. W. Mathieson,G. Baddeley,W. Pickles J. Chem. Soc. 1953 3706
• 3. Notes
  D. W. Ockenden,K. Schofield,Walter Freund,Alfred Komzak,S. A. Faseeh,H. J. Callomon,H. W. Thompson,F. Allan Andersen,B?rge Bak,D. E. A. Rivett,K. T. Potts,W. H. T. Davison,A. G. Sharpe,Richard O. Whipple,Robert West,Kenneth Emerson,Alexander Mackie,A. Anthony Cutler,V. M. Ingram,Douglas Lloyd,Frederick Rowe,E. R. H. Jones,J. D. Bu'Lock,Phyllis D. Landauer,H. N. Rydon,L. N. Owen,S. P. Whitelaw,Vincent C. Barry,P. W. D. Mitchell,D. B. Cowell,W. H. Linnell,D. W. Mathieson,G. Baddeley,W. Pickles J. Chem. Soc. 1953 3706
• 4. On the constitution and the structure of ultramarine
  F. M. Jaeger Trans. Faraday Soc. 1929 25 320

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidones

Comprehensive Analysis of 6-Amino-5-nitroso-2-thiouracil (CAS No. 1672-48-6): Properties, Applications, and Research Insights

6-Amino-5-nitroso-2-thiouracil (CAS No. 1672-48-6) is a heterocyclic organic compound with significant relevance in pharmaceutical and biochemical research. This yellow crystalline solid, often abbreviated as ANTU in specialized literature, belongs to the thiouracil derivatives family. Its unique molecular structure, featuring both amino and nitroso functional groups attached to the thiouracil backbone, enables diverse chemical reactivity. Researchers frequently investigate its role as a precursor in synthesizing nucleoside analogs and enzyme inhibitors, particularly in studies related to antiviral agents and anticancer drug discovery.

The compound's structure-activity relationship (SAR) has garnered attention in medicinal chemistry circles, especially with rising interest in targeted cancer therapies and RNA-modifying enzymes. Recent publications highlight its potential as a scaffold for developing tyrosine kinase inhibitors, aligning with current trends in personalized medicine. Analytical techniques like HPLC-MS and NMR spectroscopy confirm its high purity (>98%) in commercial samples, making it valuable for high-throughput screening platforms. Environmental scientists also examine its biodegradation pathways due to growing concerns about sustainable chemistry practices.

In synthetic applications, 6-Amino-5-nitroso-2-thiouracil demonstrates remarkable versatility. Its nitroso group participates in cycloaddition reactions, while the thione moiety enables metal coordination chemistry—properties exploited in developing fluorescence probes for cellular imaging. The compound's solubility profile (soluble in DMSO, slightly soluble in water) makes it suitable for in vitro biological assays, a feature frequently queried in research forums. Stability studies indicate optimal storage at -20°C under inert atmosphere, addressing common laboratory handling questions from first-time users.

The pharmacological interest in this compound stems from its enzyme inhibition capabilities, particularly against dihydroorotate dehydrogenase (DHODH)—a target in autoimmune disease research. This connection to immunomodulation mechanisms has spurred patent filings since 2020, coinciding with increased searches for small molecule immunotherapeutics. Computational chemists utilize its structure for molecular docking simulations, contributing to drug repurposing studies during recent global health challenges.

Quality control protocols for CAS 1672-48-6 emphasize HPLC purity analysis and residual solvent testing, reflecting industry standards for research-grade chemicals. Suppliers typically provide COA (Certificate of Analysis) documentation, a critical factor for researchers comparing chemical vendors online. The compound's electrochemical properties also attract materials scientists developing organic semiconductors, linking it to renewable energy applications—a trending topic in green chemistry discussions.

Emerging studies explore 6-Amino-5-nitroso-2-thiouracil's role in nucleic acid chemistry, where it serves as a building block for modified RNA bases. This application gains traction with advancements in mRNA vaccine technology, though current uses remain primarily in basic research settings. The compound's UV-Vis absorption characteristics (λmax ~340 nm) make it useful for spectroscopic quantification methods, as detailed in recent analytical chemistry publications.

Regulatory databases classify this material as non-hazardous under standard handling conditions, though proper PPE (personal protective equipment) is recommended—a frequent query in laboratory safety searches. Its molecular weight of 172.16 g/mol and melting point range (decomposition above 250°C) are routinely verified parameters in QC laboratories. The growing demand for high-purity specialty chemicals has positioned this compound as a valuable research reagent in academic and industrial settings alike.

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