Cas no 165800-07-7 (Zoledronic Acid Disodium Salt Tetrahydrate)
Zoledronic Acid Disodium Salt Tetrahydrate Chemical and Physical Properties
Names and Identifiers
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- Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-Phosphonoethyl)phosphonate tetrahydrate
- (1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid disodium salt tetrahydrate
- Zoledronate disodium tetrahydrate
- Zoledronic Acid Diso
- Zoledronic Acid Disodium Salt Tetrahydrate
- CGP-42446A
- Disodium salt tetrahydrate
- Zoledronate Disodium, CGP-42446A
- Zoledronate DisodiuM (C5H8N2Na2O7P24H2O)
- 165800-07-7
- AKOS015901649
- Sodium(1-hydroxy-2-(1H-imidazol-1-yl)-1-Phosphonoethyl)phosphonatetetrahydrate
- Disodium (1-Hydroxy-2-Imidazol-1-yl-1-Phosphono-Ethyl)Phosphonic Acidtetrahydrate
- disodium;(1-hydroxy-2-imidazol-1-yl-1-phosphonatoethyl)phosphonic acid;tetrahydrate
- FT-0675918
- Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, sodium salt, hydrate (1:2:4)
- ZOLEDRONATE DISODIUM, TETRAHYDRATE
- ZOLEDRONIC ACID, DISODIUM SALT, TETRAHYDRATE
- DISODIUM TETRAHYDRATE 1-HYDROXY-2-(IMIDAZOL-1-YL)-1-PHOSPHONOETHYLPHOSPHONATE
-
- Inchi： 1S/C5H10N2O7P2.2Na.4H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;;;;;;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);;;4*1H2/q;2*+1;;;;/p-2
- InChI Key： IEJZOPBVBXAOBH-UHFFFAOYSA-L
- SMILES： P(C(CN1C=NC=C1)(O)P(=O)([O-])[O-])(=O)(O)O.[Na+].[Na+].O.O.O.O
Computed Properties
- Exact Mass: 388.00200
- Monoisotopic Mass: 388.00247189g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 7
- Hydrogen Bond Acceptor Count: 12
- Heavy Atom Count: 22
- Rotatable Bond Count: 3
- Complexity: 339
- Covalently-Bonded Unit Count: 7
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 163?2
Experimental Properties
- Melting Point: 305-307°C
- Solubility: Water (Sapringly)
- PSA: 215.31000
- LogP: -0.49620
Zoledronic Acid Disodium Salt Tetrahydrate Customs Data
- HS CODE：2933290090
- Customs Data：
China Customs Code:
2933290090Overview:
2933290090. Other compounds with non fused imidazole ring in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Zoledronic Acid Disodium Salt Tetrahydrate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM187425-1g |
Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate |
165800-07-7 | 95% | 1g |
$729 | 2021-08-05 | |
| TRC | Z623500-25mg |
Zoledronic Acid Disodium Salt Tetrahydrate |
165800-07-7 | 25mg |
$ 109.00 | 2023-09-05 | ||
| TRC | Z623500-50mg |
Zoledronic Acid Disodium Salt Tetrahydrate |
165800-07-7 | 50mg |
$ 155.00 | 2023-09-05 | ||
| TRC | Z623500-100mg |
Zoledronic Acid Disodium Salt Tetrahydrate |
165800-07-7 | 100mg |
$ 292.00 | 2023-04-12 | ||
| TRC | Z623500-250mg |
Zoledronic Acid Disodium Salt Tetrahydrate |
165800-07-7 | 250mg |
$ 667.00 | 2023-09-05 | ||
| TRC | Z623500-500mg |
Zoledronic Acid Disodium Salt Tetrahydrate |
165800-07-7 | 500mg |
$ 1229.00 | 2023-04-12 | ||
| Alichem | A069004576-1g |
Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-Phosphonoethyl)phosphonate tetrahydrate |
165800-07-7 | 95% | 1g |
$628.00 | 2022-04-02 | |
| Chemenu | CM187425-1g |
Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate |
165800-07-7 | 95% | 1g |
$729 | 2023-01-19 | |
| Biosynth | FZ28773-25 mg |
Zoledronic acid, disodium salt, tetrahydrate |
165800-07-7 | 25mg |
$63.00 | 2023-01-04 | ||
| Biosynth | FZ28773-50 mg |
Zoledronic acid, disodium salt, tetrahydrate |
165800-07-7 | 50mg |
$103.50 | 2023-01-04 |
Zoledronic Acid Disodium Salt Tetrahydrate Related Literature
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Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
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Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
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Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
Additional information on Zoledronic Acid Disodium Salt Tetrahydrate
Zoledronic Acid Disodium Salt Tetrahydrate: A Comprehensive Overview
Zoledronic acid disodium salt tetrahydrate, with the CAS number 165800-07-7, is a critical compound in the field of bone metabolism and antiresorptive therapy. This compound is a bisphosphonate, a class of drugs known for their ability to inhibit bone resorption by targeting osteoclasts. The compound's chemical structure includes a disodium salt form, which enhances its solubility and bioavailability, making it suitable for various therapeutic applications.
Recent studies have highlighted the efficacy of zoledronic acid disodium salt tetrahydrate in the treatment of osteoporosis, particularly in postmenopausal women. Clinical trials have demonstrated significant increases in bone mineral density (BMD) when administered intravenously. The compound's ability to inhibit farnesyl pyrophosphate synthase (FPPS), a key enzyme in the mevalonate pathway, has been extensively researched. This inhibition leads to apoptosis of osteoclasts, thereby reducing bone resorption and promoting bone formation.
In addition to its role in treating osteoporosis, zoledronic acid disodium salt tetrahydrate has shown promise in managing other skeletal disorders such as Paget's disease of bone and tumor-induced osteomalacia. Recent advancements in drug delivery systems have further enhanced its therapeutic potential. For instance, the development of sustained-release formulations has improved patient compliance and reduced the frequency of administration.
The synthesis and characterization of zoledronic acid disodium salt tetrahydrate involve a series of chemical reactions, including the formation of the bisphosphonate backbone and subsequent sodium salt formation. The compound's stability under various pH conditions has been a focus of recent research, with findings indicating that it maintains its efficacy even under physiological pH levels.
From an environmental perspective, the biodegradability and ecological impact of zoledronic acid disodium salt tetrahydrate have been studied to ensure sustainable use. Research indicates that the compound undergoes efficient biodegradation under aerobic conditions, minimizing its environmental footprint.
In conclusion, zoledronic acid disodium salt tetrahydrate (CAS No: 165800-07-7) stands as a pivotal agent in modern bone health management. Its versatility across multiple therapeutic applications, coupled with ongoing research into its mechanisms and delivery systems, underscores its importance in both clinical practice and pharmaceutical innovation.
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