• 1. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 2. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 3. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 4. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543
• 5. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

Exploring the Versatile Applications of 1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine (CAS No. 165404-21-7) in Modern Chemistry

1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine (CAS No. 165404-21-7) is a heterocyclic compound that has garnered significant attention in pharmaceutical and materials science research. This pyrazole-pyridine hybrid structure exhibits unique electronic properties, making it valuable for diverse applications. The compound's molecular formula is C9H10N4, with a molecular weight of 174.20 g/mol. Its distinctive structure combines the aromatic characteristics of pyridine with the versatile reactivity of pyrazole, creating a scaffold that's particularly interesting for drug discovery and functional materials development.

Recent studies highlight the growing importance of pyrazole-pyridine hybrids in medicinal chemistry, with 1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine serving as a key intermediate. Researchers are particularly interested in its potential as a building block for kinase inhibitors, given the crucial role of both pyrazole and pyridine moieties in many FDA-approved drugs. The compound's ability to participate in hydrogen bonding and π-π stacking interactions makes it valuable for designing molecules with specific biological activities.

The synthesis of CAS 165404-21-7 typically involves multi-step organic reactions, with careful control of reaction conditions to ensure high purity. Common synthetic routes may include condensation reactions between appropriately substituted pyrazole and pyridine precursors, followed by selective methylation. The purity and characterization of this compound are critical, with techniques like HPLC, NMR, and mass spectrometry being routinely employed for quality control in research settings.

In materials science, 1-methyl-4-(pyridin-4-yl)-1H-pyrazole-5-amine derivatives have shown promise in the development of organic semiconductors and luminescent materials. The compound's conjugated system and ability to coordinate with metal ions make it suitable for creating novel functional materials with applications in OLED technology and sensors. Recent publications have explored its use in creating metal-organic frameworks (MOFs) with interesting photophysical properties.

From a pharmaceutical perspective, the pyrazol-5-amine moiety in this compound is particularly noteworthy. This functional group appears in numerous bioactive molecules, and researchers are actively investigating its potential in developing new therapeutics. The compound's structural features make it a valuable scaffold for creating molecules with potential applications in treating various conditions, though specific therapeutic claims would require extensive clinical validation.

The commercial availability of 1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine (CAS 165404-21-7) has increased in recent years, reflecting growing research interest. Suppliers typically offer this compound in various quantities, with purity grades ranging from 95% to 98% or higher for research applications. Proper storage conditions (usually at 2-8°C in a dry environment) are recommended to maintain stability over extended periods.

Analytical characterization of this compound reveals interesting physicochemical properties. The presence of both basic (pyridine nitrogen) and potentially acidic (pyrazole NH) sites gives it amphoteric character, which can be exploited in various applications. Researchers have studied its solubility profile, finding that it's generally soluble in common organic solvents like DMSO and methanol, but has limited solubility in water.

Recent patent literature shows growing interest in pyridinyl-pyrazole amine derivatives, with CAS 165404-21-7 serving as a key intermediate in several patented synthetic routes. The compound's versatility as a building block is demonstrated by its appearance in patents covering diverse applications from pharmaceuticals to specialty chemicals. This trend suggests continued research interest and potential commercial applications in coming years.

Safety considerations for handling 1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine follow standard laboratory protocols for organic compounds. While not classified as highly hazardous, appropriate personal protective equipment including gloves and eye protection is recommended when working with this material. Material safety data sheets (MSDS) provided by suppliers contain detailed handling and disposal information.

The future research directions for this compound appear promising, with several groups investigating novel derivatives and applications. Particularly interesting are studies exploring its use in asymmetric catalysis and as a ligand in transition metal complexes. The compound's structural features make it suitable for creating chiral catalysts, which are valuable tools in synthetic organic chemistry.

From a regulatory perspective, 1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine (CAS 165404-21-7) is not currently subject to significant restrictions in most jurisdictions, making it accessible for research purposes. However, researchers should always verify the latest regulatory status before initiating work, as chemical regulations can change. The compound's increasing popularity in medicinal chemistry research suggests it may become more widely used in coming years.

In conclusion, 1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine represents an interesting example of how hybrid heterocyclic systems can offer unique opportunities in both pharmaceutical and materials science research. Its combination of pyrazole and pyridine rings creates a versatile scaffold that continues to attract research attention across multiple disciplines. As synthetic methodologies advance and our understanding of structure-activity relationships improves, this compound and its derivatives will likely play increasingly important roles in scientific innovation.

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