• 1. A nanocarrier pesticide delivery system with promising benefits in the case of dinotefuran: strikingly enhanced bioactivity and reduced pesticide residue
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• 2. A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health
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• 3. Dinotefuran nano-pesticide with enhanced valid duration and controlled release properties based on a layered double hydroxide nano-carrier
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• 4. Development of a high-throughput multi-residue method for analysis of common pesticides in aquatic environments by automated online solid phase extraction coupled with LC-MS/MS
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• 5. Simultaneous determination of four neonicotinoid insecticides residues in cereals, vegetables and fruits using ultra-performance liquid chromatography/tandem mass spectrometry
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Nitroguanidines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Guanidines Nitroguanidines

Dinotefuran (CAS No. 165252-70-0): A Comprehensive Overview

Dinotefuran, chemically designated as 1-(6-chloro-2-pyrimidinyl)-N-(2,6-difluorobenzyl)-N-methylurea, is a compound with significant applications in the field of agrochemicals. Its unique chemical structure and mode of action have made it a subject of extensive research and development. This introduction aims to provide a detailed exploration of Dinotefuran, focusing on its chemical properties, mechanism of action, and the latest research findings.

The molecular formula of Dinotefuran is C₁₂H₁₀ClF₂N₃O₂, and its CAS number is 165252-70-0. This compound belongs to the neonicotinoid class of insecticides, which are known for their high efficacy against a broad spectrum of pests. The structure of Dinotefuran incorporates several key functional groups that contribute to its potent insecticidal activity, including a pyrimidine ring, a chloro substituent, and two fluorine atoms.

Dinotefuran exerts its effects primarily by targeting the insect nervous system. It functions as a potent agonist of nicotinic acetylcholine receptors (nAChRs), which are crucial for neurotransmission in insects. By binding to these receptors, Dinotefuran disrupts normal neural communication, leading to symptoms such as tremors, paralysis, and ultimately death in pest insects. This mechanism of action makes it highly effective against a variety of agricultural pests.

One of the most notable features of Dinotefuran is its high selectivity towards insects over mammals. This selectivity is attributed to differences in the sensitivity and distribution of nAChRs between insects and vertebrates. Research has shown that Dinotefuran has a much lower affinity for mammalian nAChRs compared to its insecticidal target sites. This characteristic has made it a preferred choice for use in crop protection, minimizing the risk to non-target organisms.

In recent years, there has been growing interest in the environmental impact of neonicotinoid insecticides, including Dinotefuran. Studies have been conducted to assess their persistence in soil and water systems, as well as their potential effects on non-target species such as pollinators. While some concerns have been raised regarding the impact on beneficial insects like bees, research has also highlighted the importance of proper application practices to mitigate these risks.

The latest research on Dinotefuran has focused on developing more sustainable and environmentally friendly formulations. Innovations in this area include the use of slow-release technologies and bio-based carriers that reduce environmental release while maintaining efficacy against target pests. These advancements aim to address the growing demand for eco-friendly pest management solutions.

Furthermore, studies have explored the potential role of Dinotefuran in integrated pest management (IPM) strategies. IPM approaches emphasize the use of multiple tactics to control pests effectively while minimizing environmental impact. Dinotefuran can be integrated with cultural controls, biological controls, and other chemical treatments to create comprehensive pest management programs that are both effective and sustainable.

The mode of action of Dinotefuran has also been studied at a molecular level to understand its interactions with biological targets more deeply. Research using advanced techniques such as X-ray crystallography has provided insights into how Dinotefuran binds to nAChRs and modulates their activity. These findings have not only enhanced our understanding of the compound's mechanism but also paved the way for the development of new insecticides with improved properties.

Efficacy trials have demonstrated that Dinotefuran is highly effective against a range of agricultural pests, including aphids, whiteflies, and leafminers. Its ability to provide long-lasting protection makes it particularly valuable for protecting crops throughout their growth cycle. Field studies have shown that formulations containing Dinotefuran can significantly reduce pest populations and improve crop yields.

The safety profile of Dinotefuran has been thoroughly evaluated through extensive toxicological studies. These studies have assessed its acute toxicity, chronic toxicity, and potential long-term health effects. The results consistently indicate that Dinotefuran is safe for use when handled according to label instructions. Regulatory agencies worldwide have approved its use in agriculture based on these safety assessments.

In conclusion, Dinotefuran (CAS No. 165252-70-0) is a potent and selective insecticide with a well-understood mode of action. Its high efficacy against a broad spectrum of pests, combined with its favorable safety profile, makes it an important tool in modern crop protection strategies. Ongoing research continues to explore new applications and formulations that enhance its environmental sustainability and effectiveness.

• 184848-84-8(Guanidine, N-formyl-N'-methyl-N''-nitro-N-[(tetrahydro-3-furanyl)methyl]-)
• 527698-45-9(Guanidine, N-(3-ethoxy-2-methylpropyl)-N'-methyl-N''-nitro-)
• 406466-28-2(GUANIDINE, N-(3-METHOXYPROPYL)-N'-METHYL-N''-NITRO-)
• 406466-40-8(Guanidine, N-methyl-N'-[1-methyl-1-(tetrahydro-3-furanyl)ethyl]-N''-nitro-)
• 406466-53-3(Dinotefuran, (R)-)
• 165253-13-4(1,3,5-Triazin-2(1H)-imine,tetrahydro-1,5-dimethyl-N-nitro-3-[(tetrahydro-3-furanyl)methyl]-)
• 322639-07-6(Guanidine, N-methyl-N'-nitro-N''-[[(3S)-tetrahydro-3-furanyl]methyl]-)
• 165252-77-7(Guanidine, N,N,N'-trimethyl-N''-nitro-N'-[(tetrahydro-3-furanyl)methyl]-)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)