• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. An investigation of the electrochemical delithiation process of carbon coated α-Fe2O3nanoparticles
  Adrian Brandt,Florian Winter,Sebastian Klamor,Frank Berkemeier,Jatinkumar Rana,Rainer P?ttgen,Andrea Balducci J. Mater. Chem. A, 2013,1, 11229-11236
• 3. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 4. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 5. An intermolecular C–H oxidizing strategy to access highly fused carbazole skeletons from simple naphthylamines?
  Christian K. Rank,Alexander W. Jones,Tatjana Wall,Patrick Di Martino-Fumo,Sarah Schr?ck,Markus Gerhards,Frederic W. Patureau Chem. Commun., 2019,55, 13749-13752

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Guide to Methyl 3-(dimethylamino)benzoate (CAS No. 16518-64-2): Properties, Applications, and Industry Insights

Methyl 3-(dimethylamino)benzoate (CAS No. 16518-64-2) is a versatile organic compound widely utilized in pharmaceutical synthesis, agrochemical formulations, and specialty chemical research. This ester derivative, featuring a dimethylamino substituent, exhibits unique physicochemical properties that make it valuable for intermediate synthesis and catalysis. With growing interest in green chemistry and sustainable manufacturing, researchers are exploring its role in energy-efficient processes.

The molecular structure of Methyl 3-(dimethylamino)benzoate combines a benzoate ester core with an electron-donating dimethylamino group, granting it distinct solubility in polar solvents like methanol and acetonitrile. Recent studies highlight its potential in photocatalysis applications, aligning with the global focus on renewable energy solutions. Analytical techniques such as HPLC and GC-MS are commonly employed for purity verification, addressing industry demands for high-precision chemicals.

In pharmaceutical contexts, this compound serves as a precursor for active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) therapeutics. Its structural motif appears in several drug candidates undergoing clinical trials, reflecting the compound's relevance to drug discovery trends. The cosmetics industry also explores its derivatives for UV-absorbing properties, responding to consumer demand for advanced sunscreen formulations.

From a regulatory standpoint, Methyl 3-(dimethylamino)benzoate complies with major chemical inventories including REACH and TSCA, ensuring its global accessibility for research. Storage recommendations typically suggest ambient temperature conditions in airtight containers to maintain stability, a critical consideration for quality control professionals. The compound's thermal decomposition profile has been extensively studied to meet industrial safety standards.

Emerging applications include its use in organic electronic materials, where its electron-rich aromatic system contributes to charge transport properties. This aligns with the booming flexible electronics market and the search for non-toxic semiconductor components. Analytical data sheets typically report a melting point range of 45-48°C and boiling point around 280°C, with detailed spectroscopic characteristics available in major chemical databases.

Environmental considerations for 16518-64-2 include biodegradability studies and ecotoxicological assessments, reflecting the chemical industry's emphasis on sustainable development goals. Recent patent literature reveals innovative uses in controlled-release formulations and smart materials, demonstrating the compound's adaptability to cutting-edge technologies. Suppliers often provide custom synthesis options to meet specific research and development requirements.

The global market for Methyl 3-(dimethylamino)benzoate shows steady growth, driven by expanding pharmaceutical outsourcing and contract manufacturing activities. Quality benchmarks typically specify ≥98% purity by chromatographic analysis, with some specialty grades reaching 99.9% for high-performance applications. Technical bulletins frequently address common user queries regarding solvent compatibility, scaling-up procedures, and derivatization techniques.

Academic research continues to uncover novel reactions involving this compound, particularly in metal-catalyzed coupling and click chemistry protocols. Its structure-activity relationships remain a subject of investigation for medicinal chemistry applications. The compound's logP value and other physicochemical parameters make it a valuable reference material for QSAR modeling in drug design.

• 104542-38-3(Methyl Ester 3-(Methylamino)benzoic Acid)
• 54941-06-9(methyl 3-amino-4-(dimethylamino)benzoate)
• 1202-25-1(Methyl 4-(dimethylamino)benzoate)
• 21903-30-0(Benzoic acid, 3,5-bis(dimethylamino)-, methyl ester)
• 398469-98-2(Benzoic acid, 4-(methylphenylamino)-, methyl ester)
• 89611-01-8(Benzoic acid,3,5-bis(methylamino)-, methyl ester)
• 18358-63-9(Methyl 4-(methylamino)benzoate)
• 39617-05-5(dimethyl 4-dimethylaminophthalate)
• 136825-35-9(Benzoic acid, 3-amino-5-(dimethylamino)-, methyl ester (9CI))
• 255835-96-2(Benzoic acid, 3-(methylphenylamino)-, methyl ester)