Production Method 1

6781-98-2

1632385-49-9

90649-78-8

Reaction Conditions

1.1 Reagents: Trimethylaluminum (reaction products with ethanol) Catalysts: Di-μ-chlorobis[1,1′-(1,2-ethanediyl)bis[1,1-dicyclohexylphosphine-κP]]dirhodium Solvents: Dimethylacetamide ,  Tetramethylurea ;  > 1 min, rt
1.2 6 h, 145 °C

Reference

Direct carboxylation of simple arenes with CO2 through a rhodium-catalyzed C-H bond activation

Suga, Takuya; Mizuno, Hajime; Takaya, Jun; Iwasawa, Nobuharu, Chemical Communications (Cambridge, 2014, 50(92), 14360-14363

3-Chloro-2,4-dimethylbenzoic acid Raw materials

• 2-Chloro-m-xylene

3-Chloro-2,4-dimethylbenzoic acid Preparation Products

• 4-Chloro-3,5-dimethylbenzoic acid (90649-78-8)
• 3-Chloro-2,4-dimethylbenzoic acid (1632385-49-9)

• 1. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 2. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871
• 3. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 4. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 5. An investigation of new infrared nonlinear optical material: BaCdSnSe4, and three new related centrosymmetric compounds: Ba2SnSe4, Mg2GeSe4, and Ba2Ge2S6?
  Kui Wu,Zhihua Yang,Shilie Pan Dalton Trans., 2015,44, 19856-19864

3-Chloro-2,4-Dimethylbenzoic Acid (CAS No. 1632385-49-9): A Comprehensive Overview

The compound 3-Chloro-2,4-Dimethylbenzoic Acid (CAS No. 1632385-49-9) is a significant organic compound with a diverse range of applications in various fields, including pharmaceuticals, agrochemicals, and materials science. This compound is characterized by its unique structure, which combines a benzoic acid moiety with chlorine and methyl substituents at specific positions on the aromatic ring. The presence of these substituents imparts distinct chemical and physical properties to the molecule, making it a valuable building block in organic synthesis.

Recent advancements in synthetic chemistry have led to the development of novel methods for the preparation of 3-Chloro-2,4-Dimethylbenzoic Acid. Researchers have explored various routes, including Friedel-Crafts acylation and Suzuki coupling reactions, to synthesize this compound with high efficiency and purity. These methods not only enhance the scalability of production but also contribute to the sustainability of chemical processes by minimizing waste and reducing energy consumption.

The structural uniqueness of 3-Chloro-2,4-Dimethylbenzoic Acid makes it an attractive candidate for use in drug discovery programs. Its ability to act as a chiral auxiliary or a bioisostere has been extensively studied in recent years. For instance, studies have shown that this compound can serve as a potential lead molecule in the development of anti-inflammatory and anticancer agents due to its ability to modulate key biological pathways.

In addition to its role in pharmaceuticals, 3-Chloro-2,4-Dimethylbenzoic Acid has found applications in agrochemicals as well. Its derivatives have been investigated for their pesticidal properties, particularly as fungicides and insecticides. Recent research has focused on optimizing the bioavailability and efficacy of these derivatives through structural modifications.

The environmental impact of 3-Chloro-2,4-Dimethylbenzoic Acid has also been a topic of interest in recent studies. Scientists have evaluated its biodegradability and toxicity profiles under various environmental conditions. These studies aim to ensure that the use of this compound does not pose significant risks to ecosystems or human health.

Furthermore, the compound has been utilized in materials science for the synthesis of advanced materials such as polymers and nanoparticles. Its ability to act as a versatile monomer has opened new avenues for developing high-performance materials with tailored properties.

In conclusion, 3-Chloro-2,4-Dimethylbenzoic Acid (CAS No. 1632385-49-9) is a versatile compound with a wide range of applications across multiple disciplines. Ongoing research continues to uncover new potential uses and improve its synthesis methods, ensuring its relevance in both academic and industrial settings.

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