Production Method 1

922-67-8

163083-65-6

858515-77-2

Reaction Conditions

1.1 Solvents: Acetonitrile ;  4 h, 82 °C
1.2 Reagents: Oxalic acid Solvents: Dichloromethane ;  1 h, rt

Reference

A New Method for the Synthesis of 3-Substituted Indoles

Natarajan, Rakesh; et al, Synlett, 2015, 26(17), 2467-2471

Production Method 2

486-25-9

163083-65-6

858515-77-2

Reaction Conditions

1.1 Reagents: Boron trifluoride etherate Solvents: Ethanol ,  Chloroform ;  15 min, reflux
2.1 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane ;  5 h, < 5 °C
3.1 Solvents: Acetonitrile ;  4 h, 82 °C
3.2 Reagents: Oxalic acid Solvents: Dichloromethane ;  1 h, rt

Reference

A New Method for the Synthesis of 3-Substituted Indoles

Natarajan, Rakesh; et al, Synlett, 2015, 26(17), 2467-2471

Production Method 3

922-67-8

163083-65-6

858515-77-2

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Rhodium Solvents: Tetrahydrofuran ;  rt → 0 °C; 0 °C; 3 h, 0 °C
1.2 Catalysts: Dabco Solvents: Dichloromethane ;  rt → 0 °C; 0 °C; 1 h

Reference

A general and scalable synthesis of polysubstituted indoles

Tejedor, David; et al, Molecules, 2020, 25(23),

Production Method 4

163083-65-6

858515-77-2

Reaction Conditions

1.1 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane ;  5 h, < 5 °C
2.1 Solvents: Acetonitrile ;  4 h, 82 °C
2.2 Reagents: Oxalic acid Solvents: Dichloromethane ;  1 h, rt

Reference

A New Method for the Synthesis of 3-Substituted Indoles

Natarajan, Rakesh; et al, Synlett, 2015, 26(17), 2467-2471

methyl 6-methyl-1H-indole-3-carboxylate Raw materials

• methyl prop-2-ynoate
• 9-Fluorenone

methyl 6-methyl-1H-indole-3-carboxylate Preparation Products

• methyl 4-methyl-1H-indole-3-carboxylate (858515-77-2)
• methyl 6-methyl-1H-indole-3-carboxylate (163083-65-6)

• 1. Evolution and characterization of a benzylguanine-binding RNA aptamer?
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• 4. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolecarboxylic acids and derivatives

• 776-41-0(Ethyl indole-3-carboxylate)
• 942-24-5(Methyl indole-3-carboxylate)
• 227960-12-5(5-Methylindole-3-carboxylic acid methyl ester)
• 312973-24-3(Methyl 3-formyl-1H-indole-7-carboxylate)
• 197506-83-5(Methyl 3-formyl-1H-indole-5-carboxylate)
• 133831-28-4(Methyl 3-formylindole-6-carboxylate)
• 947412-98-8(1H-Indole-5-carboxylic acid, 3-(hydroxymethyl)-, methyl ester)
• 773134-49-9(Methyl 7-methyl-1H-indole-3-carboxylate)
• 53462-88-7(Methyl 3-formyl-1H-indole-4-carboxylate)
• 65923-27-5(3-(hydroxymethyl)-1H-Indole-4-carboxylic acid methyl ester)