Production Method 1

1243572-47-5

162129-68-2

89487-99-0

776-53-4

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  10 min, 50 °C
1.2 Reagents: Hydrochloric acid ;  pH 2, 0 - 2 °C

Reference

Regarding the intramolecular cyclization of ethyl (E)-2-cyano-3-(S-methylisothioureido)-2-propenoate

Gefenas, V.; Stankeviciute, Z.; Malinauskas, A.; Tumkevicius, S., Chemistry of Heterocyclic Compounds (New York, 2010, 46(3), 363-366

(Z)-ethyl 2-cyano-3-ureidoacrylate Raw materials

• 2-Propenoic acid, 2-cyano-3-[[imino(methylthio)methyl]amino]-, ethyl ester, (2E)-

(Z)-ethyl 2-cyano-3-ureidoacrylate Preparation Products

• (Z)-ethyl 2-cyano-3-ureidoacrylate (162129-68-2)
• 5-Cyano-4-hydroxy-2-(methylthio)pyrimidine (89487-99-0)
• ethyl 4-amino-2-(methylsulfanyl)pyrimidine-5-carboxylate (776-53-4)

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