• 1. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 2. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles

6-Fluoro-1H-indole-2-boronic acid (CAS No. 1613450-44-4): A Versatile Boronic Acid Derivative with Expanding Applications

6-Fluoro-1H-indole-2-boronic acid (CAS 1613450-44-4) is an important boronic acid derivative that has gained significant attention in pharmaceutical research and organic synthesis. This fluorinated indole boronic acid compound serves as a valuable building block for Suzuki-Miyaura cross-coupling reactions, one of the most widely used methods for carbon-carbon bond formation in medicinal chemistry.

The molecular structure of 6-Fluoro-1H-indole-2-boronic acid features both an indole scaffold and a boronic acid functional group, making it particularly useful for creating complex molecules. The fluoro substitution at the 6-position enhances the compound's electronic properties and metabolic stability, which is why researchers frequently search for "fluoro indole boronic acid applications" and "1613450-44-4 solubility properties" when working with this material.

In recent years, the demand for 6-Fluoro-1H-indole-2-boronic acid has increased significantly due to its role in developing kinase inhibitors and other bioactive compounds. Many pharmaceutical researchers investigate "indole boronic acid drug discovery" and "CAS 1613450-44-4 price" as this compound shows promise in various therapeutic areas. The boronic acid moiety is particularly valuable for creating protease inhibitors and other targeted therapies.

The synthesis and handling of 6-Fluoro-1H-indole-2-boronic acid require specific conditions to maintain its stability. Common search queries like "how to store 6-Fluoro-1H-indole-2-boronic acid" and "1613450-44-4 stability data" reflect the practical concerns of chemists working with this compound. Proper storage under inert atmosphere and protection from moisture are essential for preserving its reactivity in cross-coupling reactions.

From a commercial perspective, 6-Fluoro-1H-indole-2-boronic acid (CAS 1613450-44-4) has become more accessible in recent years, with multiple suppliers offering this compound in various quantities. Market trends show growing interest in "bulk 6-Fluoro-1H-indole-2-boronic acid" and "custom synthesis of fluorinated boronic acids", indicating its expanding applications in both academic and industrial settings.

The analytical characterization of 6-Fluoro-1H-indole-2-boronic acid typically involves techniques such as NMR spectroscopy, HPLC analysis, and mass spectrometry. Researchers often look for "1613450-44-4 NMR data" and "6-Fluoro-1H-indole-2-boronic acid purity specifications" when verifying the quality of this compound for their synthetic applications.

Looking forward, the applications of 6-Fluoro-1H-indole-2-boronic acid are expected to grow in fields such as bioconjugation chemistry and materials science. Emerging search trends include "indole boronic acid sensors" and "fluoro indole polymers", suggesting new directions for this versatile compound beyond its traditional uses in pharmaceutical intermediates.

For researchers considering 6-Fluoro-1H-indole-2-boronic acid (CAS 1613450-44-4) for their projects, it's important to consult recent literature on "indole boronic acid reactivity" and "fluorinated heterocycle synthesis". The compound's unique combination of structural features makes it particularly valuable for creating diverse molecular architectures with potential biological activity.

In conclusion, 6-Fluoro-1H-indole-2-boronic acid represents an important tool in modern synthetic chemistry, with applications ranging from drug discovery to materials development. Its CAS number 1613450-44-4 has become increasingly recognized in scientific databases, reflecting the growing importance of this fluorinated boronic acid derivative in cutting-edge research across multiple disciplines.

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