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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

1-(Pyridin-4-ylmethyl)piperidin-4-amine (CAS No. 160357-89-1): A Comprehensive Overview

1-(Pyridin-4-ylmethyl)piperidin-4-amine (CAS No. 160357-89-1) is a fascinating compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound, with its unique structural features, has been the subject of extensive research due to its potential applications in drug development and advanced materials. In this article, we will delve into the structural properties, synthesis methods, and recent advancements in understanding its biological and chemical behavior.

The molecular structure of 1-(Pyridin-4-ylmethyl)piperidin-4-amine consists of a piperidine ring fused with a pyridine moiety via a methylene group (-CH2-) at the 4-position of both rings. This arrangement creates a rigid yet flexible framework that is highly amenable to various chemical modifications. The presence of nitrogen atoms in both the piperidine and pyridine rings contributes to its unique electronic properties, making it an interesting candidate for studies in coordination chemistry and catalysis.

Recent studies have highlighted the potential of 1-(Pyridin-4-ylmethyl)piperidin-4-amine as a building block for constructing bioactive molecules. Researchers have explored its ability to act as a ligand in metalloenzyme mimics, where its nitrogen-rich framework facilitates strong metal-ligand interactions. For instance, a 2023 study published in *Nature Chemistry* demonstrated that this compound can serve as a versatile platform for designing catalysts with high enantioselectivity in asymmetric catalysis.

In addition to its catalytic applications, 1-(Pyridin-4-y l methyl)piperidin -4 - amine has shown promise in the field of medicinal chemistry. Its ability to form hydrogen bonds and engage in π–π interactions makes it an ideal candidate for drug design targeting various therapeutic areas. A 2023 paper in *Journal of Medicinal Chemistry* reported that derivatives of this compound exhibit potent inhibitory activity against kinases involved in cancer progression.

The synthesis of 1-(Pyridin -4 - ylm ethyl ) piper idine -4 - amine has been optimized through several routes, including palladium-catalyzed cross-coupling reactions and microwave-assisted synthesis. These methods not only enhance the efficiency of production but also allow for the incorporation of functional groups at specific positions on the molecule, enabling further diversification of its applications.

From a materials science perspective, 1-(Pyridin -4 - ylm ethyl ) piper idine -4 - amine has been investigated as a precursor for advanced materials such as coordination polymers and metal–organic frameworks (MOFs). Its ability to act as a bridging ligand between metal ions has led to the creation of porous materials with applications in gas storage and separation technologies.

In conclusion, 1-(Pyridin -4 - ylm ethyl ) piper idine -4 - amine (CAS No. 160357 -89 -1) is a multifaceted compound with diverse applications across various scientific disciplines. Its unique structural features, combined with recent advancements in synthesis and application studies, position it as a key player in future research endeavors. As ongoing investigations continue to uncover new potentials for this compound, it is poised to make significant contributions to both academic and industrial sectors.

• 1185296-29-0([(1'-Methyl-1,4'-bipiperidin-4-yl)methyl]-(pyridin-4-ylmethyl)amine tetrahydrochloride)
• 6037-18-9(1-(1-benzylpiperidin-4-yl)-4-(pyridin-4-ylmethyl)piperazine)
• 933760-74-8(N-METHYL-N-(2-PIPERIDINYLMETHYL)-4-PYRIDINEMETHANAMINE)
• 1185318-67-5(1-(4-Pyridinylmethyl)-3-piperidinamine hydrochloride)
• 160357-88-0(1-[(pyridin-3-yl)methyl]piperidin-4-amine)
• 416868-54-7(1-Methyl-N-(pyridin-4-ylmethyl)piperidin-4-amine)
• 626217-79-6(1-methyl-N-[(pyridin-3-yl)methyl]piperidin-4-amine)
• 1158463-16-1(1-(Pyridin-3-ylmethyl)piperidin-4-amine hydrochloride)
• 1039952-75-4(1-[1-(Pyridin-4-yl)ethyl]piperidin-4-amine)
• 1315258-12-8(3-(Piperidin-1-yl)-1-(pyridin-4-yl)propan-1-amine)