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  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 2. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
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• 3. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

Comprehensive Guide to 2,4-Dipropoxybenzaldehyde (CAS No. 156744-09-1): Properties, Applications, and Market Insights

2,4-Dipropoxybenzaldehyde (CAS No. 156744-09-1) is a specialized organic compound widely used in the synthesis of fine chemicals, pharmaceuticals, and fragrances. This aromatic aldehyde features two propoxy groups at the 2- and 4-positions of the benzene ring, enhancing its reactivity and solubility in organic solvents. Its unique structure makes it a valuable intermediate in organic synthesis, particularly for constructing complex molecules with high precision.

The chemical properties of 2,4-dipropoxybenzaldehyde include a molecular formula of C13H18O3 and a molecular weight of 222.28 g/mol. It typically appears as a pale yellow to colorless liquid with a characteristic aromatic odor. The compound exhibits moderate stability under standard conditions but should be stored away from strong oxidizing agents to prevent degradation. Researchers often utilize 2,4-dipropoxybenzaldehyde CAS 156744-09-1 in reactions such as condensation, oxidation, and nucleophilic addition due to its reactive aldehyde group.

In the pharmaceutical industry, 2,4-dipropoxybenzaldehyde serves as a key building block for synthesizing active pharmaceutical ingredients (APIs). Its structural flexibility allows for the creation of diverse drug candidates, particularly in the development of anti-inflammatory and antimicrobial agents. Recent studies have explored its potential in designing novel small-molecule inhibitors, aligning with the growing demand for targeted therapies in precision medicine.

The fragrance and flavor sector extensively employs 2,4-dipropoxybenzaldehyde 156744-09-1 as a precursor for creating unique olfactory compounds. Its aromatic profile contributes to the formulation of woody, spicy, and amber-like notes in perfumery. With consumers increasingly seeking sustainable and naturally-inspired fragrances, this compound plays a crucial role in developing eco-friendly aroma chemicals that mimic natural extracts.

Material science applications of 2,4-dipropoxybenzaldehyde include its use in synthesizing advanced polymers and liquid crystals. The propoxy groups enhance the compound's compatibility with various polymer matrices, making it valuable for creating specialty coatings with improved adhesion and durability. In the field of organic electronics, researchers are investigating derivatives of this compound for potential use in organic light-emitting diodes (OLEDs) and photovoltaic materials.

From a market perspective, the demand for 2,4-dipropoxybenzaldehyde CAS No. 156744-09-1 has shown steady growth, particularly in Asia-Pacific regions where pharmaceutical and fragrance industries are expanding rapidly. Manufacturers are focusing on developing cost-effective synthesis routes to meet the increasing demand while maintaining high purity standards. The compound typically sells at premium prices in the range of $50-$100 per gram for laboratory-scale quantities, with bulk pricing available for industrial customers.

Quality control for 2,4-dipropoxybenzaldehyde involves rigorous analytical testing including HPLC, GC-MS, and NMR spectroscopy to ensure ≥98% purity. Suppliers often provide detailed technical data sheets and certificates of analysis to support research and industrial applications. Proper handling requires standard laboratory precautions, including the use of personal protective equipment and adequate ventilation, though the compound is not classified as highly hazardous under most regulatory frameworks.

Recent innovations in green chemistry have explored eco-friendly synthesis methods for 2,4-dipropoxybenzaldehyde 156744-09-1, such as catalytic processes using renewable feedstocks. These advancements align with the chemical industry's shift toward sustainable production practices and reduced environmental impact. Researchers are also investigating biocatalytic routes using engineered enzymes as potential alternatives to traditional synthetic methods.

For researchers working with 2,4-dipropoxybenzaldehyde, common experimental considerations include optimizing reaction conditions to maximize yield and selectivity. The compound's sensitivity to light and air oxidation necessitates careful storage in amber glass containers under inert atmosphere when long-term stability is required. Analytical chemists frequently employ derivatization techniques to enhance the detectability of this compound in complex matrices.

The future outlook for 2,4-dipropoxybenzaldehyde CAS 156744-09-1 appears promising, with potential applications emerging in agrochemicals and functional materials. As synthetic methodologies continue to advance, this versatile intermediate will likely find expanded use across multiple industries. Ongoing research into its derivatives may unlock new biological activities and material properties, further increasing its commercial value and scientific importance.

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