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Comprehensive Overview of Valine-1-13C (9CI) (CAS No. 152840-81-8): Applications and Significance in Modern Research

Valine-1-13C (9CI), identified by its CAS No. 152840-81-8, is a stable isotope-labeled derivative of the essential amino acid valine. This compound is increasingly pivotal in metabolic studies, pharmaceutical research, and nutritional science due to its 13C isotopic labeling at the first carbon position. Researchers leverage its unique properties to trace metabolic pathways, quantify protein turnover, and investigate disease mechanisms with unparalleled precision. The demand for such labeled compounds has surged alongside advancements in NMR spectroscopy and mass spectrometry, making Valine-1-13C a cornerstone in isotopic tracer methodologies.

One of the most compelling applications of Valine-1-13C lies in cancer metabolism research. Recent studies highlight its role in elucidating how tumors reprogram amino acid metabolism to fuel growth—a hotspot topic in oncology. For instance, searches for "isotope-labeled amino acids in cancer" or "13C valine metabolic tracing" have spiked by 40% year-over-year, reflecting growing interest in precision medicine tools. Additionally, the compound’s utility in sports nutrition research—such as measuring muscle protein synthesis rates—aligns with trending queries like "best amino acids for muscle recovery" and "how isotopes improve athletic performance studies."

The synthesis of Valine-1-13C adheres to stringent Good Manufacturing Practices (GMP), ensuring high isotopic enrichment (>99%) and chemical purity. This reliability is critical for reproducibility in peer-reviewed studies, a factor underscored by frequent searches for "high-purity labeled amino acids." Furthermore, its compatibility with cell culture and animal models makes it indispensable for in vivo research, addressing common user questions like "how to trace amino acids in living systems."

Beyond biomedical fields, Valine-1-13C is gaining traction in agricultural science for studying nitrogen assimilation in crops. With global searches for "sustainable farming using isotopes" rising, this compound offers insights into optimizing fertilizer use—a pressing concern amid climate change debates. Its non-toxic, stable isotope nature also aligns with eco-conscious trends, differentiating it from radioactive tracers in queries such as "safe alternatives to radioactive labels."

In summary, Valine-1-13C (9CI) (CAS No. 152840-81-8) exemplifies the convergence of cutting-edge science and real-world applications. From decoding cancer metabolism to advancing sustainable agriculture, its versatility meets both academic and industrial demands. As search trends reveal, professionals increasingly seek "isotope-labeled compounds with clinical relevance"—a niche where this molecule excels, cementing its status as a vital tool in 21st-century research.

• 516-06-3(DL-Valine)
• 328-39-2((±)-Leucine)
• 72-18-4(L-Valine)
• 328-38-1((2R)-2-amino-4-methylpentanoic acid)
• 640-68-6((2R)-2-amino-3-methyl-butanoic acid)
• 31872-98-7(5-Methyl-L-norleucine)
• 443-79-8(DL-Isoleucine)
• 61-90-5(L-Leucine)
• 73-32-5(L-Isoleucine)
• 1509-34-8(L-Allo-isoleucine)