• 1. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 2. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Alkaloids and derivatives
• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives

Anabasine Hydrochloride (CAS No. 15251-47-5): A Comprehensive Overview

Anabasine Hydrochloride (CAS No. 15251-47-5) is a synthetic compound that has garnered significant attention in the fields of chemistry, pharmacology, and medicinal research. This compound, also known as Nicotinic Receptor Agonist, is structurally similar to nicotine and exhibits a range of biological activities. In this comprehensive overview, we will delve into the chemical properties, pharmacological effects, and recent research developments surrounding Anabasine Hydrochloride.

Chemical Properties and Structure

Anabasine Hydrochloride is a white crystalline powder with the molecular formula C11H14N2·HCl and a molecular weight of 206.70 g/mol. It is soluble in water and ethanol, making it suitable for various pharmaceutical applications. The compound's structure consists of a pyridine ring and a piperidine ring connected by a methylene bridge, which contributes to its unique pharmacological profile.

The chemical stability of Anabasine Hydrochloride is notable, as it remains stable under standard laboratory conditions. However, it is important to store the compound in a cool, dry place to prevent degradation. The compound's solubility and stability make it an attractive candidate for formulation in various dosage forms, including tablets, capsules, and injectable solutions.

Pharmacological Effects

Anabasine Hydrochloride acts as a nicotinic acetylcholine receptor (nAChR) agonist, which means it binds to and activates nAChRs in the central nervous system (CNS) and peripheral tissues. This action can lead to a variety of physiological effects, including increased neurotransmitter release, modulation of ion channels, and alteration of cellular signaling pathways.

In the CNS, Anabasine Hydrochloride has been shown to have both stimulatory and inhibitory effects on neuronal activity. It can enhance cognitive function by increasing the release of neurotransmitters such as acetylcholine and dopamine. Additionally, it has been studied for its potential in treating neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.

In peripheral tissues, Anabasine Hydrochloride can affect smooth muscle contraction and relaxation. This property has led to its investigation as a potential therapeutic agent for conditions such as irritable bowel syndrome (IBS) and chronic obstructive pulmonary disease (COPD).

Clinical Applications and Research Developments

The therapeutic potential of Anabasine Hydrochloride has been explored in various clinical settings. Recent studies have focused on its use in smoking cessation programs due to its ability to mimic the effects of nicotine without the harmful side effects associated with tobacco use. Clinical trials have shown promising results in reducing nicotine cravings and improving smoking cessation rates.

In addition to smoking cessation, Anabasine Hydrochloride has been investigated for its potential in pain management. Preclinical studies have demonstrated that the compound can reduce pain sensitivity by modulating nAChRs in the spinal cord and brainstem. These findings suggest that Anabasine Hydrochloride may have applications in treating chronic pain conditions such as neuropathic pain.

Safety and Toxicology

The safety profile of Anabasine Hydrochloride is an important consideration for its use in therapeutic applications. Preclinical studies have shown that the compound is generally well-tolerated at therapeutic doses. However, like other nicotinic receptor agonists, it can cause side effects such as nausea, dizziness, and increased heart rate at higher doses.

To ensure safe use, ongoing research is focused on optimizing dosing regimens and identifying patient populations most likely to benefit from treatment with Anabasine Hydrochloride. Additionally, efforts are being made to develop formulations that minimize side effects while maximizing therapeutic efficacy.

Conclusion

Anabasine Hydrochloride (CAS No. 15251-47-5) is a versatile compound with significant potential in various therapeutic areas. Its unique chemical structure and pharmacological properties make it an attractive candidate for further research and development. As ongoing studies continue to uncover new applications and optimize its use, Anabasine Hydrochloride is poised to play an increasingly important role in modern medicine.

• 494-52-0(Anabasine)
• 13078-04-1(3-(Piperidin-2-yl)pyridine)
• 66148-18-3((±)-Nornicotine-d)
• 40774-73-0(( /-)-ANABASINE)
• 130342-99-3(2-(Pyridin-3-yl)azepane)
• 18793-19-6(Pyridine,3-[(2R,4S)-2-(3-pyridinyl)-4-piperidinyl]-, rel-)
• 126741-11-5(5-Methyl Nornicotine)
• 494-97-3(3-[(2S)-pyrrolidin-2-yl]pyridine)
• 5746-86-1((±)-Nornicotine)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)