Cas no 152460-10-1 (6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine)

6-Methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine is a heterocyclic organic compound featuring a pyrimidine core linked to a pyridine ring and a substituted benzene diamine moiety. This structure confers potential utility in pharmaceutical and agrochemical research, particularly as a scaffold for kinase inhibitors or other biologically active molecules. The compound's pyrimidine-pyridine hybrid system enhances binding affinity in target interactions, while the methyl-substituted diamine group offers tunable reactivity for further derivatization. Its well-defined molecular architecture makes it suitable for structure-activity relationship (SAR) studies. The compound is typically characterized by high purity and stability under standard laboratory conditions, ensuring reliability in synthetic applications.
6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine structure
152460-10-1 structure
Product Name:6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
CAS No:152460-10-1
MF:C16H15N5
MW:277.323802232742
MDL:MFCD09028125
CID:65278
PubChem ID:125307407
Update Time:2025-10-16

6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine Chemical and Physical Properties

Names and Identifiers

    • N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
    • 4-Methyl-N'-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
    • 4-methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline
    • N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine
    • 4-Methyl-N3-[4-(3-Pyridinyl)-2-Pyrimidinyl]-1,3-Benzenediamine
    • N-(5-amino-2-methylphenyl)-4-(3-pyridinyl)-2-pydimidineamine
    • 1,3-BENZENEDIAMINE,4-METHYL-N3-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-
    • 6-Methyl-n1-[4-(pyridine-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
    • 2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine
    • 6-Methyl-N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
    • C16H15N5
    • N-(5-AMINO-2-METHYL)-4-(3-PYRIDYL)-2-PYRIMIDIME AMINE
    • 4-methyl-3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine
    • 4-Methyl-N3-[4-(3-pyridyl)-2-pyrimidinyl]-1,3-phenylenediamine
    • N-(5-Amino-o-tolyl)-4-(3-pyridyl)-2-pyrimidinamine
    • 4-Methyl-N3-[4-(pyridin-3-yl)pyrimidin-2-yl]-1,3-benzenediamine
    • IMatinib IMpurity C
    • Imatinib EP Impurity F
    • Imatinib USP Impurity F
    • IMatinib interMediates
    • (5,AMINO 2-MethylPHENYL) 4,(3,PYRIDYL) 2,PYRIMIDINEAMINE
    • 152460-10-1
    • 6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
    • SY046834
    • 1,3-Benzenediamine, 4-methyl-N3-(4-(3-pyridinyl)-2-pyrimidinyl)-
    • Q-100177
    • IMATINIB AMINE [USP IMPURITY]
    • N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine amine
    • 6-Methyl-N1-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,2-diamine
    • Imatinib Mesilate Imprity F [EP IMPURITY]
    • SCHEMBL2392
    • QGAIPGVQJVGBIA-UHFFFAOYSA-N
    • 4-methyl-N3-[4-(3-piridinyl)-2-pirimidinyl]-1,3-benzendiamine
    • DS-0284
    • AC-2147
    • Imatinib amine [USP]
    • 1,3-Benzenediamine, 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-
    • 4-Methyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
    • BDBM50287097
    • AKOS015888614
    • MFCD09028125
    • CS-W014568
    • Imatinib amine
    • N-(5-Amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine
    • BCP22918
    • 112GI007
    • SB60556
    • 4-Methyl-N3-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
    • n-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine
    • AM20050827
    • N-(5-amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidine-amine
    • VU0549314-1
    • DTXSID30433443
    • 4-Methyl-N~3~-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
    • CCG-310976
    • 4-Methyl-N*3*-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine
    • CHEMBL278103
    • Imatinib Impurity F
    • FT-0696298
    • N-(5-Amino-2-methyl phenyl)-4-(3-pyridyl)-2-pyrimidineamine
    • 6-Methyl-N1-[4-(3-pyridyl)-2-pyrimidinyl]-1,3-benzenediamine
    • N-(5-amino-2-methyl phenyl)-4-(3-pyridinyl)2-pyrimidine-amine
    • F9995-0188
    • Z1741977607
    • FT-0647597
    • 4-methyl-N~3~-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine
    • EN300-7372570
    • 6-Methyl-N-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
    • UNII-JR9RZF7KDS
    • NS00077786
    • AC-619
    • N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine
    • VCC489937
    • FT-0655675
    • JR9RZF7KDS
    • Imatinib impurity D
    • A2308
    • N-(5-Amino-2-methylphenyl)-4-(3-pridyl)-2-pyrimidineamine
    • MDL： MFCD09028125
    • Inchi： 1S/C16H15N5/c1-11-4-5-13(17)9-15(11)21-16-19-8-6-14(20-16)12-3-2-7-18-10-12/h2-10H,17H2,1H3,(H,19,20,21)
    • InChI Key： QGAIPGVQJVGBIA-UHFFFAOYSA-N
    • SMILES： N(C1N=CC=C(C2C=NC=CC=2)N=1)C1C=C(C=CC=1C)N
    • BRN： 7539016

Computed Properties

  • Exact Mass: 277.13300
  • Monoisotopic Mass: 277.13274550g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 3
  • Complexity: 324
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 3
  • XLogP3: 2.4
  • Topological Polar Surface Area: 76.7?2

Experimental Properties

  • Color/Form: Powder
  • Density: 1.266
  • Melting Point: 143.0 to 147.0 deg-C
  • Boiling Point: 537.3°C at 760 mmHg
  • Flash Point: 278.8±32.9 °C
  • Refractive Index: 1.688
  • PSA: 76.72000
  • LogP: 3.82700

6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine Security Information

6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine Customs Data

  • HS CODE：2934999090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine Suppliers

Suzhou Senfeida Chemical Co., Ltd
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(CAS:152460-10-1)N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
Order Number:sfd6369;1688903
Stock Status:in Stock
Quantity:200kg/Company Customization
Purity:99.9%/98%
Pricing Information Last Updated:Friday, 19 July 2024 14:34
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:152460-10-1)伊瑪胺
Order Number:LE1688903
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:33
Price ($):discuss personally

6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine Spectrogram

1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR

6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine Related Literature

Additional information on 6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine

Comprehensive Analysis of 6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine (CAS No. 152460-10-1): Properties, Applications, and Research Insights

The compound 6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine (CAS No. 152460-10-1) is a structurally intricate organic molecule that has garnered significant attention in pharmaceutical and materials science research. Its unique pyrimidine and pyridine hybrid architecture makes it a promising candidate for drug discovery, particularly in kinase inhibition and targeted therapies. Researchers are increasingly exploring its potential in cancer treatment, inflammatory diseases, and neurodegenerative disorders, aligning with current trends in precision medicine.

From a chemical perspective, this compound features a benzene-1,3-diamine core substituted with a 6-methyl group and a 4-(pyridin-3-yl)pyrimidin-2-yl moiety. This configuration contributes to its hydrogen bonding capacity and π-stacking interactions, critical for binding with biological targets. Recent studies indexed in PubMed highlight its role as a scaffold modifier in medicinal chemistry, with particular relevance to tyrosine kinase inhibitors – a hot topic in oncology research and AI-driven drug design platforms.

The synthesis of CAS 152460-10-1 typically involves multi-step organic reactions, including Buchwald-Hartwig amination and Suzuki coupling, processes frequently searched by chemistry professionals. Analytical characterization via HPLC, NMR, and mass spectrometry confirms its high purity (>98%), making it suitable for high-throughput screening applications. In material science, its conjugated system shows potential for organic electronics, particularly in OLED development – an area experiencing exponential growth due to demand for flexible displays.

Current market trends show rising demand for small molecule pharmaceuticals containing heterocyclic compounds like this derivative. Patent analyses reveal its inclusion in several drug candidate formulations, especially those targeting EGFR mutations and angiogenesis pathways. The compound's logP value (predicted 2.8-3.2) and aqueous solubility profile make it particularly interesting for oral bioavailability optimization studies, a frequent challenge in medicinal chemistry forums.

Environmental and safety assessments indicate that 6-methyl-N1-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine requires standard laboratory precautions. Its thermal stability (decomposition >250°C) and photostability data support its suitability for long-term storage, a practical consideration for research laboratories. Regulatory databases show no major restrictions, though proper waste disposal protocols should be followed, in line with green chemistry principles increasingly demanded by funding agencies.

Future research directions may explore its structure-activity relationships through computational modeling, a trending approach combining AI algorithms with quantitative structure-activity relationship (QSAR) studies. The compound's crystallographic data could further inform molecular docking simulations, addressing common search queries about drug-target interactions. With the global pharmaceutical intermediates market projected to grow at 6.5% CAGR, such specialized compounds will remain crucial for innovative therapeutic development.

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