Cas no 15149-73-2 (Carbonochloridic acid,2,5-dioxo-1-pyrrolidinyl ester)

Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester, is a highly reactive acylating agent commonly used in organic synthesis for the introduction of the carbonyl chloride functional group. Its key advantages include high reactivity with nucleophiles, making it effective for peptide coupling and acylation reactions. The succinimidyl ester moiety enhances stability and selectivity, facilitating controlled reactions under mild conditions. This compound is particularly valuable in the synthesis of pharmaceuticals, agrochemicals, and specialty polymers. Its crystalline form ensures ease of handling and storage, while its consistent purity supports reproducible results in complex synthetic pathways. Proper handling under anhydrous conditions is recommended due to its moisture sensitivity.
Carbonochloridic acid,2,5-dioxo-1-pyrrolidinyl ester structure
15149-73-2 structure
Product Name:Carbonochloridic acid,2,5-dioxo-1-pyrrolidinyl ester
CAS No:15149-73-2
MF:C5H4ClNO4
MW:177.542560577393
CID:120832
PubChem ID:10419734
Update Time:2025-10-29

Carbonochloridic acid,2,5-dioxo-1-pyrrolidinyl ester Chemical and Physical Properties

Names and Identifiers

    • Carbonochloridic acid,2,5-dioxo-1-pyrrolidinyl ester
    • N-HYDROXYSUCCINIMIDYL CHLOROFORMATE
    • Chlorameisensaeure-succinimid
    • chloroformic acid N-hydroxysuccinimide-ester
    • N-Chlorcarbonyloxy-succinimid
    • N-Hydoxysuccinimidylchloroformate
    • N-succinimidyl chloroformate
    • succinimidochloroformate
    • SUO-CL
    • 15149-73-2
    • 2,5-DIOXOPYRROLIDIN-1-YL CHLOROFORMATE
    • (2,5-dioxopyrrolidin-1-yl) carbonochloridate
    • 2,5-DIOXOPYRROLIDIN-1-YL CARBONOCHLORIDATE
    • succinimidyl chloroformate
    • SCHEMBL1580294
    • AKOS006292971
    • SY309446
    • EN300-6481042
    • MFCD05663750
    • SCHEMBL4286777
    • 2,5-Dioxo-1-pyrrolidinyl Chloroformate
    • Inchi: 1S/C5H4ClNO4/c6-5(10)11-7-3(8)1-2-4(7)9/h1-2H2
    • InChI Key: NVKZKCWZPSNZFD-UHFFFAOYSA-N
    • SMILES: ClC(=O)ON1C(CCC1=O)=O

Computed Properties

  • Exact Mass: 176.98300
  • Monoisotopic Mass: 176.9828853g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 2
  • Complexity: 211
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.3
  • Topological Polar Surface Area: 63.7?2

Experimental Properties

  • PSA: 63.68000
  • LogP: 0.36370

Carbonochloridic acid,2,5-dioxo-1-pyrrolidinyl ester Customs Data

  • HS CODE:2925190090
  • Customs Data:

    China Customs Code:

    2925190090

    Overview:

    2925190090 Other imides and their derivative salts. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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Carbonochloridic acid,2,5-dioxo-1-pyrrolidinyl ester Related Literature

Additional information on Carbonochloridic acid,2,5-dioxo-1-pyrrolidinyl ester

Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester (CAS No. 15149-73-2): A Comprehensive Overview

Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester (CAS No. 15149-73-2) is a versatile compound with significant applications in various fields, including pharmaceuticals, chemical synthesis, and materials science. This compound is known for its unique chemical structure and reactivity, making it an essential reagent in numerous synthetic processes.

The chemical structure of Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester consists of a pyrrolidinone ring with a chlorocarbonyl group attached to the nitrogen atom. The presence of the chlorocarbonyl group imparts high reactivity to the molecule, enabling it to participate in a wide range of chemical reactions. This reactivity is particularly useful in the synthesis of complex organic molecules and pharmaceutical intermediates.

Recent research has highlighted the importance of Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester in the development of new drugs and therapeutic agents. For instance, a study published in the *Journal of Medicinal Chemistry* demonstrated that this compound can be used as a key intermediate in the synthesis of novel anti-inflammatory drugs. The high reactivity and stability of Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester make it an ideal choice for such applications.

In addition to its role in pharmaceutical synthesis, Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester has also found applications in materials science. Researchers at the University of California have explored its use in the synthesis of advanced polymers and coatings. The unique properties of this compound allow for the creation of materials with enhanced mechanical strength and thermal stability.

The synthesis of Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester typically involves the reaction of pyrrolidine-2,5-dione with phosgene or a phosgene equivalent. This process requires careful control of reaction conditions to ensure high yield and purity. Recent advancements in green chemistry have led to the development of more environmentally friendly methods for synthesizing this compound. For example, a study published in *Green Chemistry* reported a novel method using a catalytic system that significantly reduces the formation of hazardous by-products.

The safety and handling of Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester are crucial considerations for researchers and industrial users. While this compound is not classified as a hazardous material under current regulations, it is important to follow standard safety protocols when handling it. Proper personal protective equipment (PPE) should be worn, and the compound should be stored in a well-ventilated area away from incompatible materials.

In conclusion, Carbonochloridic acid, 2,5-dioxo-1-pyrrolidinyl ester (CAS No. 15149-73-2) is a valuable compound with diverse applications in pharmaceuticals, chemical synthesis, and materials science. Its unique chemical properties and high reactivity make it an essential reagent for researchers and industrial chemists alike. Ongoing research continues to uncover new uses and improvements in the synthesis and application of this important compound.

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