Cas no 147149-98-2 (2-(trifluoromethyl)pyridin-4-amine)

2-(Trifluoromethyl)pyridin-4-amine is a fluorinated pyridine derivative featuring an amine functional group at the 4-position and a trifluoromethyl substituent at the 2-position. This compound is valued for its electron-withdrawing trifluoromethyl group, which enhances its reactivity and stability in various synthetic applications. Its structure makes it a versatile intermediate in pharmaceutical and agrochemical research, particularly in the development of active ingredients requiring fluorine-containing motifs. The amine group allows for further functionalization, enabling its use in coupling reactions, heterocyclic synthesis, and as a building block for bioactive molecules. Its well-defined chemical properties and high purity make it suitable for precision applications in organic and medicinal chemistry.
2-(trifluoromethyl)pyridin-4-amine structure
147149-98-2 structure
Product Name:2-(trifluoromethyl)pyridin-4-amine
CAS No:147149-98-2
MF:C6H5F3N2
MW:162.112511396408
MDL:MFCD09056877
CID:65022
PubChem ID:10261388
Update Time:2025-05-19

2-(trifluoromethyl)pyridin-4-amine Chemical and Physical Properties

Names and Identifiers

    • 4-Amino-2-(trifluoromethyl)pyridine
    • 2-(Trifluoromethyl)pyridin-4-amine
    • 2-Trifluoromethyl-4-amino-pyridine
    • 2-trifluoromethylpyridin-4-amine
    • 2-Trifluoromethyl-pyridin-4-ylamine
    • 4-Amino-2-trifluoromethylpyridine
    • 2-(Trifluoromethyl)pyridin-4-amine 4-Amino-2-trifluoromethylpyridine
    • Enasidenib Intermediate 4
    • 2-trifluoromethyl-4-aminopyridine
    • 4-Pyridinamine, 2-(trifluoromethyl)-
    • 4-Amino-2-(trifluoromethyl)-pyridine
    • 2-(Trifluoromethyl)pyridin-4-amine (4-Amino-2-trifluoromethylpyridine)
    • 2-Ctrifluoromethyl
    • pyridin-4-amine
    • 2-Ctrifluoromethyl/pyridin-4-amine
    • 2-CTRIFLUOROMETHYL/PYRIDIN-4-AMINE,98%
    • SY005986
    • 2-Trifluoromethyl-pyridin-4-ylamine;4-Amino-2-(trifluoromethyl)pyridine
    • CS-W003591
    • WUHNTSDGYSSGKD-UHFFFAOYSA-N
    • DTXSID10437429
    • MFCD09056877
    • FT-0649569
    • AC-7384
    • AM803229
    • AKOS005145778
    • BCP06615
    • 4-Amino-2-(trifluoromethyl)pyridine, 97%
    • A3215
    • J-514310
    • EN300-135606
    • 4-amino-2-trifluormethylpyridine
    • A808618
    • 147149-98-2
    • SCHEMBL111794
    • AB49691
    • 2-(trifluoromethyl)-4-pyridinamine
    • FS-2586
    • A2861
    • DS-015922
    • DB-038082
    • BBL101775
    • STL555572
    • 1-O-(2-methoxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
    • 2-(trifluoromethyl)pyridin-4-amine
    • MDL： MFCD09056877
    • Inchi： 1S/C6H5F3N2/c7-6(8,9)5-3-4(10)1-2-11-5/h1-3H,(H2,10,11)
    • InChI Key： LYNBZRJTRHTSKI-UHFFFAOYSA-N
    • SMILES： FC(C1C=C(C=CN=1)N)(F)F

Computed Properties

  • Exact Mass: 162.04000
  • Monoisotopic Mass: 162.04048265g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 134
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: 1.1
  • Topological Polar Surface Area: 38.9?2

Experimental Properties

  • Color/Form: White to Yellow Solid
  • Density: 1.369
  • Melting Point: 58-62?°C
  • Boiling Point: 230.7°C at 760 mmHg
  • Flash Point: 230.695 °C at 760 mmHg
  • Refractive Index: 1.479
  • PSA: 38.91000
  • LogP: 2.26380

2-(trifluoromethyl)pyridin-4-amine Security Information

  • Symbol: GHS06
  • Signal Word：Danger
  • Hazard Statement： H301-H319
  • Warning Statement： P301+P310-P305+P351+P338
  • Hazardous Material transportation number：UN 2811 6.1 / PGIII
  • WGK Germany：3
  • Hazard Category Code： 25-36-43
  • Safety Instruction： 26-36/37
  • Hazardous Material Identification： T Xi
  • HazardClass：6.1
  • PackingGroup：Ⅲ
  • Storage Condition：Keep in dark place,Inert atmosphere,Room temperature

2-(trifluoromethyl)pyridin-4-amine Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2-(trifluoromethyl)pyridin-4-amine Production Method

2-(trifluoromethyl)pyridin-4-amine Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:147149-98-2)4-Amino-2-trifluoromethylpyridine
Order Number:sfd19909
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:38
Price ($):discuss personally

2-(trifluoromethyl)pyridin-4-amine Related Literature

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Additional information on 2-(trifluoromethyl)pyridin-4-amine

2-(Trifluoromethyl)Pyridin-4-Amine: A Comprehensive Overview

The compound with CAS No. 147149-98-2, commonly referred to as 2-(trifluoromethyl)pyridin-4-amine, has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This molecule is a derivative of pyridine, a six-membered aromatic heterocycle, with a trifluoromethyl group at the 2-position and an amine group at the 4-position. The unique combination of these substituents imparts distinctive chemical properties, making it a valuable compound for various applications.

2-(Trifluoromethyl)pyridin-4-amine exhibits a range of physical and chemical properties that make it suitable for diverse applications. Its molecular formula is C6H5F3N, with a molecular weight of 166.05 g/mol. The compound is characterized by its high stability under standard conditions, which is attributed to the electron-withdrawing effects of the trifluoromethyl group and the resonance stabilization provided by the pyridine ring. This stability makes it ideal for use in demanding chemical environments.

Recent studies have highlighted the potential of 2-(trifluoromethyl)pyridin-4-amine in drug discovery. Researchers have explored its role as a building block in the synthesis of bioactive molecules, particularly in the development of kinase inhibitors and other therapeutic agents. The trifluoromethyl group enhances lipophilicity, which is crucial for drug absorption and bioavailability. Additionally, the amine group provides opportunities for further functionalization, enabling the creation of diverse pharmacophores.

In materials science, 2-(trifluoromethyl)pyridin-4-amine has been investigated as a precursor for advanced materials such as conductive polymers and coordination polymers. Its ability to act as a ligand in metal coordination complexes has opened avenues for applications in catalysis and sensing technologies. For instance, recent research has demonstrated its effectiveness in stabilizing metal nanoparticles, which are critical components in catalytic systems.

The synthesis of 2-(trifluoromethyl)pyridin-4-amine typically involves multi-step processes that combine substitution and elimination reactions. A common approach involves the substitution of a suitable pyridine derivative with a trifluoromethyl group followed by amination at the 4-position. Optimization of reaction conditions, such as temperature and solvent choice, is essential to achieve high yields and purity.

One of the most promising areas of research involving 2-(trifluoromethyl)pyridin-4-amine is its application in agrochemicals. Studies have shown that this compound exhibits potent pesticidal activity against various insect pests and pathogens. Its ability to disrupt key biochemical pathways in target organisms makes it a potential candidate for developing eco-friendly pesticides that minimize environmental impact.

In conclusion, 2-(trifluoromethyl)pyridin-4-amine (CAS No. 147149-98-2) is a versatile compound with wide-ranging applications across multiple disciplines. Its unique chemical properties, combined with recent advancements in synthesis and application techniques, position it as a valuable tool for future innovations in chemistry and related fields.

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Suzhou Senfeida Chemical Co., Ltd
(CAS:147149-98-2)4-Amino-2-trifluoromethylpyridine
sfd19909
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
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