Cas no 78448-45-0 (2,6-Bis(trifluoromethyl)pyridin-4-amine)

2,6-Bis(trifluoromethyl)pyridin-4-amine is a fluorinated pyridine derivative characterized by the presence of two trifluoromethyl groups at the 2- and 6-positions and an amine group at the 4-position. This structure imparts high electron-withdrawing properties and enhanced stability, making it valuable in pharmaceutical and agrochemical synthesis. The trifluoromethyl groups contribute to increased lipophilicity and metabolic resistance, while the amine functionality allows for further derivatization. Its reactivity and selectivity make it a useful intermediate in the development of bioactive compounds, particularly in the design of heterocyclic frameworks. The compound is typically handled under controlled conditions due to its sensitivity.

2,6-Bis(trifluoromethyl)pyridin-4-amine structure

78448-45-0 structure

Product Name:2,6-Bis(trifluoromethyl)pyridin-4-amine

CAS No:78448-45-0

MF:C₇H₄F₆N₂

MW:230.110482215881

MDL:MFCD00128909

CID:2619453

PubChem ID:615456

Update Time:2025-06-07

2,6-Bis(trifluoromethyl)pyridin-4-amine Chemical and Physical Properties

Names and Identifiers

- 2,6-bis(trifluoromethyl)pyridin-4-amine
- 4-amino-2,6-bis(trifluoromethyl)pyridine
- 4-Pyridinamine, 2,6-bis(trifluoromethyl)-
- 2,6-BIS-TRIFLUOROMETHYL-PYRIDIN-4-YLAMINE
- AB03626
- 2,6-Bis-trifluoromethylpyridin-4-ylamine
- 2,6-Bis(trifluoromethyl)-4-pyridinamine #
- Pyridin-4-amine, 2,6-bis(trifluoromethyl)-
- C7H4F6N2
- EN300-24533234
- MFCD00128909
- 78448-45-0
- SCHEMBL8788157
- DB-134156
- AKOS017344585
- SY320288
- 2,6-Bis(trifluoromethyl)pyridin-4-amine
- MDL： MFCD00128909
- Inchi： 1S/C7H4F6N2/c8-6(9,10)4-1-3(14)2-5(15-4)7(11,12)13/h1-2H,(H2,14,15)
- InChI Key： KPSPGGWCQFNRNP-UHFFFAOYSA-N
- SMILES： FC(C1C=C(C=C(C(F)(F)F)N=1)N)(F)F

Computed Properties

Exact Mass: 230.02786711 g/mol
Monoisotopic Mass: 230.02786711 g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 8
Heavy Atom Count: 15
Rotatable Bond Count: 0
Complexity: 201
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 2
Topological Polar Surface Area: 38.9
Molecular Weight: 230.11

2,6-Bis(trifluoromethyl)pyridin-4-amine Pricemore >>

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Matrix Scientific	207513-1g	2,6-Bis-trifluoromethylpyridin-4-ylamine, 97%	78448-45-0	97%	1g	$2609.00	2023-09-05
Matrix Scientific	207513-5g	2,6-Bis-trifluoromethylpyridin-4-ylamine, 97%	78448-45-0	97%	5g	$6804.00	2023-09-05
Alichem	A029002544-250mg	2,6-Bis(trifluoromethyl)-4-bromopyridine	78448-45-0	95%	250mg	$989.80	2023-09-01
Alichem	A029002544-500mg	2,6-Bis(trifluoromethyl)-4-bromopyridine	78448-45-0	95%	500mg	$1735.55	2023-09-01
Alichem	A029002544-1g	2,6-Bis(trifluoromethyl)-4-bromopyridine	78448-45-0	95%	1g	$2808.15	2023-09-01
Aaron	AR019EHR-50mg	2,6-Bis-trifluoromethyl-pyridin-4-ylamine	78448-45-0	95%	50mg	$368.00	2025-02-14
Aaron	AR019EHR-100mg	2,6-Bis-trifluoromethyl-pyridin-4-ylamine	78448-45-0	95%	100mg	$537.00	2025-02-14
Aaron	AR019EHR-250mg	2,6-Bis-trifluoromethyl-pyridin-4-ylamine	78448-45-0	95%	250mg	$754.00	2025-02-14
Aaron	AR019EHR-500mg	2,6-Bis-trifluoromethyl-pyridin-4-ylamine	78448-45-0	95%	500mg	$1174.00	2025-02-14
Aaron	AR019EHR-1g	2,6-Bis-trifluoromethyl-pyridin-4-ylamine	78448-45-0	95%	1g	$1497.00	2025-02-14