• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

2,3-dihydro-1H-inden-2-ylmethanamine (CAS No. 146737-65-7): An Overview of Its Structure, Properties, and Applications

2,3-dihydro-1H-inden-2-ylmethanamine (CAS No. 146737-65-7) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as (1S,2R)-2-amino-1-(1,3-dihydroinden-2-yl)ethane, is characterized by its unique molecular structure and diverse biological activities. In this comprehensive overview, we will delve into the chemical structure, physical properties, synthesis methods, and potential applications of this intriguing compound.

The molecular formula of 2,3-dihydro-1H-inden-2-ylmethanamine is C₁₀H₁₅N, and its molecular weight is approximately 149.23 g/mol. The compound features a fused ring system consisting of a benzene ring and a cyclohexene ring, with an amino group attached to the cyclohexene ring. This structural arrangement imparts unique chemical and physical properties to the molecule, making it a valuable candidate for various applications in drug discovery and development.

In terms of physical properties, 2,3-dihydro-1H-inden-2-ylmethanamine is typically a colorless to pale yellow liquid at room temperature. It is soluble in common organic solvents such as ethanol, methanol, and dichloromethane but has limited solubility in water. The compound exhibits moderate stability under standard laboratory conditions but may degrade upon exposure to strong acids or bases.

The synthesis of 2,3-dihydro-1H-inden-2-ylmethanamine can be achieved through several routes. One common method involves the reduction of the corresponding nitrile or imine intermediate using hydrogenation or other reducing agents. Another approach involves the reaction of an indanone derivative with an appropriate amine in the presence of a suitable catalyst. These synthetic strategies have been optimized to achieve high yields and purity levels, making the compound readily available for research purposes.

In recent years, 2,3-dihydro-1H-inden-2-ylmethanamine has been extensively studied for its potential therapeutic applications. Research has shown that this compound exhibits significant biological activities, including anti-inflammatory, analgesic, and neuroprotective effects. For instance, studies have demonstrated that 2,3-dihydro-1H-inden-2-ylmethanamine can effectively inhibit the production of pro-inflammatory cytokines such as TNF-alpha and IL-6 in vitro and in vivo models of inflammation.

Beyond its anti-inflammatory properties, 2,3-dihydro-1H-inden-2-ylmethanamine has also shown promise in the treatment of pain disorders. Preclinical studies have indicated that this compound can modulate pain pathways by interacting with specific receptors in the central nervous system. These findings suggest that 2,3-dihydro-1H-inden-2-ylmethanamine may have potential as a novel analgesic agent for managing chronic pain conditions.

In addition to its pharmacological activities, 2,3-dihydro-1H-inden-2-ylmethanamine has been investigated for its neuroprotective effects. Research has shown that this compound can protect neuronal cells from oxidative stress and apoptosis induced by various neurotoxic agents. These neuroprotective properties make it a potential candidate for the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

The safety profile of 2,3-dihydro-1H-inden-2-ylmethanamine has also been evaluated in preclinical studies. Toxicity assessments have indicated that this compound is generally well-tolerated at therapeutic doses with minimal adverse effects observed in animal models. However, further clinical trials are necessary to fully establish its safety and efficacy in human subjects.

In conclusion, 2,3-dihydro-1H-inden-2-ylmethanamine (CAS No. 146737-65-7) is a promising organic compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure and diverse biological activities make it an attractive candidate for further investigation and development as a therapeutic agent. As research in this area continues to advance, it is likely that new insights into the mechanisms of action and potential clinical applications of this compound will emerge.

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