• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 3. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 4. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 5. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088

Introduction to p-(Trifluoromethyl)phenyl Triflate (CAS No. 146397-87-7)

p-(Trifluoromethyl)phenyl Triflate, with the chemical formula C?H?F?O?S, is a highly versatile intermediate in organic synthesis and pharmaceutical development. Its unique structure, featuring a trifluoromethyl group and a triflate (CF?SO?O?) moiety, makes it a valuable tool for constructing complex molecules. This compound has garnered significant attention in recent years due to its applications in the synthesis of active pharmaceutical ingredients (APIs) and advanced materials.

The CAS No. 146397-87-7 uniquely identifies this compound in scientific literature and industrial applications. Its triflate functionality provides a highly reactive leaving group, facilitating various nucleophilic substitution reactions. This reactivity is particularly useful in the synthesis of heterocyclic compounds, which are prevalent in many modern drugs.

In the realm of pharmaceutical research, p-(Trifluoromethyl)phenyl Triflate has been employed in the development of novel therapeutic agents. The trifluoromethyl group is known to enhance the metabolic stability and lipophilicity of molecules, making them more suitable for oral administration. Recent studies have demonstrated its role in synthesizing kinase inhibitors, which are critical in treating cancers and inflammatory diseases.

One of the most compelling aspects of this compound is its utility in cross-coupling reactions. The triflate group can be selectively displaced by various nucleophiles, including aryl halides, alkoxides, and thiols, enabling the construction of diverse molecular architectures. For instance, palladium-catalyzed cross-coupling reactions using p-(Trifluoromethyl)phenyl Triflate have been reported to yield biaryl compounds with high efficiency and selectivity.

The pharmaceutical industry has also explored the use of this compound in the synthesis of antiviral and antibacterial agents. The presence of the trifluoromethyl group often confers enhanced binding affinity to biological targets, improving the efficacy of drug candidates. Additionally, its incorporation into drug molecules has been shown to prolong their half-life, reducing the frequency of dosing required.

Recent advancements in synthetic methodologies have further expanded the applications of p-(Trifluoromethyl)phenyl Triflate. For example, flow chemistry techniques have been utilized to achieve scalable and sustainable production of derivatives of this compound. These methods not only improve yield but also minimize waste, aligning with green chemistry principles.

In material science, this compound has found applications in the synthesis of advanced polymers and coatings. The trifluoromethyl group imparts unique properties such as thermal stability and chemical resistance, making it suitable for high-performance materials used in aerospace and electronics industries.

The reactivity of p-(Trifluoromethyl)phenyl Triflate also makes it a valuable intermediate in agrochemical research. Its ability to participate in various transformations allows for the development of novel pesticides and herbicides with improved environmental profiles.

As research continues to uncover new applications for this compound, its importance in synthetic chemistry is only likely to grow. The combination of its structural features and reactivity makes it an indispensable tool for chemists working across multiple disciplines.

• 176960-23-9(Methanesulfonic acid, trifluoro-, 3,5-bis(trifluoromethyl)phenyl ester)
• 52904-17-3(Phenol,3-(trifluoromethyl)-, 1-methanesulfonate)
• 66107-34-4(o-Tolyl Trifluoromethanesulfonate)
• 29540-83-8(p-Tolyl trifluoromethanesulfonate)
• 112752-02-0(Methanesulfonic acid,trifluoro-, [1,1'-biphenyl]-4,4'-diyl ester (9CI))
• 86364-02-5(Methanesulfonic acid, trifluoro-, 2,6-dimethylphenyl ester)
• 199188-29-9(2-(trifluoromethyl)phenyl trifluoromethanesulfonate)
• 87241-52-9(2,4-Dimethylphenyl Trifluoromethanesulfonate)
• 17763-78-9(Methanesulfonic acid, trifluoro-, [1,1'-biphenyl]-4-yl ester)
• 199188-30-2(3-(trifluoromethyl)phenyl trifluoromethanesulfonate)