Cas no 145441-16-3 (5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid)
5-(Fluoromethyl)-1,2-oxazole-3-carboxylic acid is a fluorinated heterocyclic compound featuring a reactive carboxylic acid group and a fluoromethyl substituent on an oxazole ring. This structure makes it a valuable intermediate in pharmaceutical and agrochemical synthesis, particularly for introducing fluorine-containing motifs into target molecules. The presence of both the fluoromethyl group and the carboxylic acid enhances its utility in medicinal chemistry, enabling further derivatization or conjugation. Its stability and compatibility with common synthetic methodologies make it suitable for diverse applications, including the development of bioactive compounds. The fluorine atom can influence metabolic stability and binding affinity, contributing to optimized drug candidates.
145441-16-3 structure
Product Name:5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid
CAS No:145441-16-3
MF:C5H4FNO3
MW:145.088564872742
CID:101627
PubChem ID:10374574
Update Time:2025-10-30
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid Chemical and Physical Properties
Names and Identifiers
-
- 3-Isoxazolecarboxylicacid, 5-(fluoromethyl)-
- 5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid
- DTXSID80438807
- WVUKMWOGVJZCSS-UHFFFAOYSA-N
- EN300-1831590
- 145441-16-3
- 5-(fluoromethyl)isoxazole-3-carboxylic acid
- AT36450
- MFCD18818566
- AKOS006379046
- 3-Isoxazolecarboxylicacid,5-(fluoromethyl)-(9CI)
- SCHEMBL6370697
-
- Inchi： 1S/C5H4FNO3/c6-2-3-1-4(5(8)9)7-10-3/h1H,2H2,(H,8,9)
- InChI Key： WVUKMWOGVJZCSS-UHFFFAOYSA-N
- SMILES： FCC1=CC(C(=O)O)=NO1
Computed Properties
- Exact Mass: 145.01752
- Monoisotopic Mass: 145.01752115g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 10
- Rotatable Bond Count: 2
- Complexity: 141
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 0.5
- Topological Polar Surface Area: 63.3?2
Experimental Properties
- PSA: 63.33
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Enamine | EN300-1831590-1g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 1g |
$1299.0 | 2023-09-19 | |
| Enamine | EN300-1831590-5g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 5g |
$3770.0 | 2023-09-19 | |
| Enamine | EN300-1831590-10g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 10g |
$5590.0 | 2023-09-19 | |
| Enamine | EN300-1831590-0.05g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 0.05g |
$301.0 | 2023-09-19 | |
| Enamine | EN300-1831590-0.1g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 0.1g |
$451.0 | 2023-09-19 | |
| Enamine | EN300-1831590-0.25g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 0.25g |
$644.0 | 2023-09-19 | |
| Enamine | EN300-1831590-0.5g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 0.5g |
$1014.0 | 2023-09-19 | |
| Enamine | EN300-1831590-1.0g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 1g |
$1299.0 | 2023-06-01 | |
| Enamine | EN300-1831590-2.5g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 2.5g |
$2548.0 | 2023-09-19 | |
| Enamine | EN300-1831590-5.0g |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid |
145441-16-3 | 95% | 5g |
$3770.0 | 2023-06-01 |
5-(fluoromethyl)-1,2-oxazole-3-carboxylic acid Related Literature
-
Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
-
Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
-
3. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imagingGhazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
-
Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
-
Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
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