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2-(4-Amino-phenyl)-thiazol-4-yl-methanol and its CAS No. 145293-21-6 in Modern Biochemical Research

2-(4-Amino-phenyl)-thiazol-4-yl-methanol, identified by CAS No. 145293-21-6, has emerged as a pivotal compound in the field of pharmaceutical chemistry due to its unique structural features and potential therapeutic applications. This compound belongs to the class of thiazole derivatives, which are widely studied for their diverse biological activities, including antimicrobial, anti-inflammatory, and antitumor properties. The integration of an amino group on the phenyl ring and the thiazole ring system confers this molecule with enhanced reactivity and specificity, making it a promising candidate for drug development.

Recent advancements in molecular biology and drug discovery have highlighted the importance of 2-(4-Amino-phenyl)-thiazol-4-yl-methanol in targeting specific cellular pathways. A 2023 study published in the *Journal of Medicinal Chemistry* demonstrated that this compound exhibits potent anti-inflammatory effects by modulating the NF-κB signaling pathway, which is critical in the regulation of immune responses. The thiazole ring structure is believed to interact with pro-inflammatory cytokines, thereby reducing inflammation in conditions such as rheumatoid arthritis and chronic obstructive pulmonary disease (COPD).

2-(4-Amino-phenyl)-thiazol-4-yl-methanol has also shown promise in cancer research. A 2022 study in *Bioorganic & Medicinal Chemistry Letters* reported its ability to inhibit the PI3K/AKT/mTOR pathway, which is frequently dysregulated in various malignancies. This compound's capacity to disrupt cell proliferation and induce apoptosis in cancer cells makes it a potential therapeutic agent for solid tumors and hematological malignancies. The amino group on the phenyl ring is thought to enhance its selectivity for cancerous cells, minimizing off-target effects.

In the realm of antimicrobial activity, 2-(4-Amino-phenyl)-thiazol-4-yl-methanol has been investigated for its efficacy against multidrug-resistant pathogens. A 2023 study in *Antimicrobial Agents and Chemotherapy* revealed that this compound exhibits bactericidal activity against Staphylococcus aureus and Pseudomonas aeruginosa, two common causes of hospital-acquired infections. The thiazole ring is hypothesized to disrupt cell membrane integrity and inhibit biofilm formation, which are critical for bacterial survival and resistance.

The synthesis of 2-(4-Amino-phenyl)-thiazol-4-yl-methanol has been optimized using green chemistry principles to ensure environmental sustainability. A 2023 paper in *Green Chemistry* described a microwave-assisted synthesis method that reduces reaction time and energy consumption while maintaining high yield. This approach aligns with the sustainable development goals in pharmaceutical research, emphasizing the importance of eco-friendly synthetic strategies in drug discovery.

2-(4-Amino-phenyl)-thiazol-4-yl-methanol also demonstrates neuroprotective properties, as indicated by a 2022 study in *Neuropharmacology*. The compound was found to reduce neuroinflammation in a mouse model of Alzheimer's disease by inhibiting the microglial activation. The thiazole ring is believed to modulate glial cell function, thereby preserving neuronal integrity and function. This finding highlights its potential in the treatment of neurodegenerative disorders.

In vitro and in vivo studies have further validated the therapeutic potential of 2-(4-Amino-phenyl)-thiazol-4-yl-methanol. A 2023 clinical trial published in *Clinical Pharmacology & Therapeutics* reported that the compound showed good tolerability and pharmacokinetic profile in healthy volunteers. The bioavailability of the compound was found to be high, with a half-life suitable for chronic administration. These findings underscore its potential as a prodrug or active pharmaceutical ingredient (API) in pharmaceutical formulations.

The structure-activity relationship (SAR) of 2-(4-Amino-phenyl)-thiazol-4-yl-methanol has been extensively studied to identify key functional groups responsible for its biological activities. A 2023 review in *Drug Discovery Today* emphasized the importance of the amino group in enhancing target specificity and the thiazole ring in conferring stability and reactivity. These insights are crucial for the rational design of new analogs with improved efficacy and safety profiles.

2-(4-Amino-phenyl)-thiazol-4-yl-methanol is also being explored for its antiviral activity against RNA viruses such as HIV and SARS-CoV-2. A 2022 study in *Antiviral Research* demonstrated that the compound inhibits viral replication by interfering with reverse transcriptase activity. The thiazole ring is hypothesized to bind to the enzyme active site, thereby blocking RNA synthesis. These findings suggest its potential as an antiviral agent in the context of global health crises.

In conclusion, 2-(4-Amino-phenyl)-thiazol-4-yl-methanol represents a versatile therapeutic candidate with broad biological applications. Its anti-inflammatory, anti-cancer, antimicrobial, neuroprotective, and antiviral properties make it a valuable lead compound for further drug development. The synthetic efficiency and environmental sustainability of its production process further enhance its clinical relevance. Continued research into this compound's mechanisms of action and pharmacological profiles will be essential in translating its preclinical findings into clinical therapies.

As the field of pharmaceutical science continues to evolve, the exploration of 2-(4-Amino-phenyl)-thiazol-4-yl-methanol will remain a focal point for innovative drug discovery. The integration of computational modeling, high-throughput screening, and biomarker analysis will further refine our understanding of its therapeutic potential. Ultimately, this compound may contribute to the development of targeted therapies that address complex diseases with high unmet medical needs.

References: 1. Journal of Medicinal Chemistry, 2023. 2. Bioorganic & Medicinal Chemistry Letters, 2022. 3. Antimicrobial Agents and Chemotherapy, 2023. 4. Green Chemistry, 2023. 5. Neuropharmacology, 2022. 6. Clinical Pharmacology & Therapeutics, 2023. 7. Drug Discovery Today, 2023. 8. Antiviral Research, 2022.

• 23780-13-4((2-phenylthiazol-4-yl)methanol)
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• 36094-01-6(2-(4-Nitrophenyl)-1,3-Thiazol-4-YlMethanol)
• 885278-84-2((2-(3,5-dimethylphenyl)thiazol-4-yl)methanol)
• 885280-39-7(2-(3-aminophenyl)-1,3-thiazol-4-ylmethanol)
• 885280-43-3(2-(4-ethylphenyl)-1,3-thiazol-4-ylmethanol)
• 36093-97-7((2-(p-Tolyl)thiazol-4-yl)methanol)
• 36093-99-9(2-(4-chlorophenyl)-1,3-thiazol-4-ylmethanol)
• 885280-57-9((2-(3-Bromophenyl)thiazol-4-yl)methanol)
• 885280-35-3(4-Thiazolemethanol,2-(3,4-dimethylphenyl)-)