• 1. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 2. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 5. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552

Introduction to N'-hydroxy-4-propoxybenzenecarboximidamide (CAS No. 145259-49-0)

N'-hydroxy-4-propoxybenzenecarboximidamide, identified by its Chemical Abstracts Service (CAS) number 145259-49-0, is a specialized organic compound that has garnered significant attention in the field of chemical and pharmaceutical research. This compound belongs to the class of imidamide derivatives, which are known for their diverse biological activities and potential applications in drug development. The unique structural features of N'-hydroxy-4-propoxybenzenecarboximidamide, particularly the presence of both hydroxyl and propoxy functional groups, contribute to its distinct chemical properties and reactivity, making it a subject of interest for synthetic chemists and biologists alike.

The synthesis of N'-hydroxy-4-propoxybenzenecarboximidamide involves a series of carefully orchestrated chemical reactions that highlight the compound's complexity. The process typically begins with the functionalization of a benzene ring, where the introduction of a propoxy group at the fourth position enhances the compound's solubility and interaction with biological targets. Subsequent steps involve the formation of an imidamide linkage, which is achieved through condensation reactions with appropriate precursors. These synthetic pathways require precise control over reaction conditions, including temperature, pH, and catalyst selection, to ensure high yields and purity.

In recent years, N'-hydroxy-4-propoxybenzenecarboximidamide has been studied for its potential pharmacological properties. Research has demonstrated that this compound exhibits inhibitory effects on certain enzymes and receptors, which are implicated in various diseases. For instance, studies have shown that it may interfere with the activity of kinases and other signaling molecules involved in cancer progression. Additionally, its structural similarity to known bioactive molecules suggests that it could serve as a scaffold for designing novel therapeutic agents.

The chemical properties of N'-hydroxy-4-propoxybenzenecarboximidamide make it a versatile intermediate in organic synthesis. Its reactivity allows for further modifications, enabling chemists to explore new derivatives with tailored biological activities. For example, researchers have investigated the effects of varying the substitution pattern on the benzene ring or introducing additional functional groups to enhance specific interactions with biological targets. These modifications are crucial in developing compounds with improved efficacy and reduced side effects.

Advances in computational chemistry have also played a significant role in understanding the behavior of N'-hydroxy-4-propoxybenzenecarboximidamide. Molecular modeling techniques allow researchers to predict how this compound interacts with biological molecules, such as proteins and nucleic acids. These predictions are invaluable in guiding experimental design and optimizing drug candidates for clinical trials. By leveraging computational methods, scientists can accelerate the discovery process and identify promising compounds more efficiently.

The potential applications of N'-hydroxy-4-propoxybenzenecarboximidamide extend beyond pharmaceuticals. Its unique chemical structure makes it suitable for use in material science and industrial chemistry. For instance, it could be employed as a building block for synthesizing polymers or as a catalyst in various chemical reactions. The versatility of this compound underscores its importance in both academic research and industrial applications.

In conclusion, N'-hydroxy-4-propoxybenzenecarboximidamide (CAS No. 145259-49-0) is a multifaceted compound with significant potential in chemical biology and drug development. Its structural features, synthetic pathways, and biological activities make it a valuable asset for researchers exploring new therapeutic strategies. As our understanding of its properties continues to grow, so too will its applications across multiple scientific disciplines.

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