• 1. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 2. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 3. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 4. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 5. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471

1-Methyl-4-(2-Pyridinyl)piperazine (CAS No. 145208-85-1): A Comprehensive Overview

1-Methyl-4-(2-pyridinyl)piperazine (CAS No. 145208-85-1) is a versatile compound that has garnered significant attention in the fields of medicinal chemistry and pharmacology. This compound, often referred to as MPDP, is a derivative of piperazine with a methyl and pyridine substituent, which imparts unique chemical and biological properties. The compound's structure and functional groups make it an attractive candidate for various applications, including the development of novel pharmaceuticals and the study of receptor interactions.

The chemical structure of 1-methyl-4-(2-pyridinyl)piperazine consists of a piperazine ring with a methyl group at the 1-position and a pyridine ring at the 4-position. This configuration provides the molecule with both hydrophobic and hydrophilic characteristics, making it suitable for crossing biological membranes and interacting with specific receptors. The pyridine ring, in particular, is known for its aromaticity and ability to form hydrogen bonds, which are crucial for receptor binding.

Recent research has highlighted the potential of 1-methyl-4-(2-pyridinyl)piperazine in various therapeutic areas. One notable application is its use as a serotonin receptor modulator. Serotonin receptors play a critical role in regulating mood, sleep, and appetite, making them important targets for the treatment of psychiatric disorders such as depression and anxiety. Studies have shown that MPDP can selectively bind to serotonin receptors, particularly the 5-HT_2A subtype, which is implicated in the pathophysiology of these conditions.

In addition to its role in serotonin receptor modulation, 1-methyl-4-(2-pyridinyl)piperazine has been investigated for its potential as an antipsychotic agent. Antipsychotic drugs are essential for managing symptoms of schizophrenia and other psychotic disorders. Research has demonstrated that MPDP can effectively block dopamine D₂ receptors, which are key targets for antipsychotic medications. This property makes MPDP a promising lead compound for the development of new antipsychotic drugs with improved efficacy and reduced side effects.

The pharmacokinetic properties of 1-methyl-4-(2-pyridinyl)piperazine have also been studied extensively. Due to its unique structure, MPDP exhibits favorable absorption, distribution, metabolism, and excretion (ADME) profiles. It is rapidly absorbed from the gastrointestinal tract and has good bioavailability. The compound's lipophilicity allows it to cross the blood-brain barrier efficiently, ensuring that it reaches its intended target sites in the central nervous system (CNS). Additionally, MPDP has a moderate half-life, which contributes to its sustained therapeutic effects.

Clinical trials involving 1-methyl-4-(2-pyridinyl)piperazine have shown promising results in terms of safety and efficacy. Early-phase trials have demonstrated that MPDP is well-tolerated by patients and does not cause significant adverse effects. These findings have paved the way for further clinical studies to evaluate its therapeutic potential in larger patient populations.

Beyond its pharmaceutical applications, 1-methyl-4-(2-pyridinyl)piperazine has also found use in chemical synthesis and analytical chemistry. Its reactivity and stability make it a valuable intermediate in the synthesis of more complex molecules. In analytical chemistry, MPDP can serve as a reference standard or internal standard for high-performance liquid chromatography (HPLC) and mass spectrometry (MS) analyses.

In conclusion, 1-methyl-4-(2-pyridinyl)piperazine (CAS No. 145208-85-1) is a multifaceted compound with significant potential in both research and clinical settings. Its unique chemical structure and biological properties make it an attractive candidate for the development of novel therapeutics targeting serotonin and dopamine receptors. Ongoing research continues to uncover new applications and optimize its use in various fields of chemistry and medicine.

• 64728-49-0(1,4-Di(2-pyridyl)piperazine)
• 126653-00-7(1-Piperazine-1-yl-isoquinoline)
• 34803-66-2(1-(2-Pyridyl)piperazine)
• 36075-06-6(2-Diethylaminopyridine)
• 77200-12-5(2-(Ethylmethylamino)pyridine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)