• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Comprehensive Overview of 3-Bromo-4-fluorobenzene-1-sulfonamide (CAS No. 1446237-76-8): Properties, Applications, and Industry Insights

3-Bromo-4-fluorobenzene-1-sulfonamide (CAS No. 1446237-76-8) is a specialized sulfonamide derivative with a unique molecular structure featuring both bromine and fluorine substituents. This compound has garnered significant attention in pharmaceutical and agrochemical research due to its potential as a building block for drug discovery and material science applications. The presence of halogen atoms in its structure enhances its reactivity, making it valuable for cross-coupling reactions and other synthetic transformations.

In recent years, the demand for fluorinated compounds like 3-Bromo-4-fluorobenzene-1-sulfonamide has surged, driven by their role in developing bioactive molecules. Researchers frequently search for "halogenated sulfonamides uses" or "fluorobenzene derivatives in drug design," reflecting the compound's relevance in modern medicinal chemistry. Its CAS No. 1446237-76-8 serves as a critical identifier for procurement and regulatory compliance across global markets.

The compound's physicochemical properties, such as solubility and stability under various conditions, are frequently studied to optimize its application in high-throughput screening and combinatorial chemistry. Analytical techniques like HPLC and NMR spectroscopy are commonly employed to characterize its purity, a topic often queried as "how to analyze sulfonamide purity" in scientific forums. These properties align with industry trends toward sustainable synthesis and green chemistry principles.

Beyond pharmaceuticals, 3-Bromo-4-fluorobenzene-1-sulfonamide is explored in material science for designing advanced polymers and electronic materials. Searches for "halogenated aromatics in OLEDs" highlight its potential in optoelectronic devices. The compound's electron-withdrawing groups contribute to tuning bandgap energies, a key focus in organic semiconductor research.

Quality control and scalable synthesis methods for CAS No. 1446237-76-8 are critical discussion points, with queries like "large-scale production of bromo-fluorobenzene sulfonamides" reflecting industrial priorities. Regulatory guidelines emphasize proper handling and documentation, though the compound is not classified under restricted categories. Its patent landscape reveals growing IP activity, particularly in kinase inhibitor formulations.

Environmental and toxicological profiles of 3-Bromo-4-fluorobenzene-1-sulfonamide are under ongoing evaluation, addressing queries such as "biodegradability of halogenated sulfonamides." Recent studies focus on structure-activity relationships (SAR) to balance efficacy with ecological safety, aligning with the EU's REACH framework and similar global standards.

In conclusion, 3-Bromo-4-fluorobenzene-1-sulfonamide (CAS No. 1446237-76-8) represents a versatile intermediate bridging multiple scientific disciplines. Its synthetic utility and alignment with industry megatrends ensure sustained relevance in both academic and industrial settings, while evolving analytical and regulatory paradigms shape its future applications.

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