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  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 2. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
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• 4. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Bromobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Bromobenzenes

Comprehensive Overview of 1-(4-bromophenyl)cyclopentane-1-carbonitrile (CAS No. 143328-19-2): Properties, Applications, and Industry Insights

1-(4-bromophenyl)cyclopentane-1-carbonitrile (CAS No. 143328-19-2) is a specialized organic compound featuring a cyclopentane ring substituted with a 4-bromophenyl group and a nitrile functional group. This structure makes it a valuable intermediate in pharmaceutical and agrochemical synthesis. The presence of both bromine and nitrile moieties enhances its reactivity, enabling diverse transformations such as cross-coupling reactions and nucleophilic substitutions. Researchers frequently explore its utility in constructing complex molecules due to its balanced steric and electronic properties.

In recent years, the demand for 1-(4-bromophenyl)cyclopentane-1-carbonitrile has surged, driven by its role in developing small-molecule drugs and crop protection agents. A trending topic in organic chemistry forums revolves around optimizing its synthesis to reduce byproducts and improve yields—a challenge addressed via catalytic methods or green chemistry principles. Questions like "How to purify 1-(4-bromophenyl)cyclopentane-1-carbonitrile?" or "Alternative routes for CAS 143328-19-2 synthesis" are commonly searched, reflecting practical industry concerns.

The compound’s physicochemical properties—such as a molecular weight of 250.12 g/mol and moderate solubility in polar solvents—are critical for formulation scientists. Its stability under ambient conditions (storage recommendations often queryed) makes it suitable for long-term use in R&D labs. Additionally, the 4-bromophenyl segment is pivotal in Suzuki-Miyaura couplings, a hot topic in metal-catalyzed reactions for constructing biaryl scaffolds prevalent in drug discovery.

From an SEO perspective, keywords like "CAS 143328-19-2 supplier", "1-(4-bromophenyl)cyclopentane-1-carbonitrile price", and "nitrile derivatives in medicinal chemistry" align with user intent. Innovators also explore its potential in material science, particularly in designing liquid crystals or polymers with tailored optoelectronic properties—a niche yet growing application area.

Regulatory compliance remains a priority; while 143328-19-2 isn’t classified as hazardous, proper handling protocols (e.g., PPE usage) are emphasized in safety data sheets. Environmental sustainability is another hotspot, with queries like "biodegradability of brominated nitriles" gaining traction. As industries pivot toward green synthesis, catalytic bromination methods for precursors of this compound are under scrutiny.

In conclusion, 1-(4-bromophenyl)cyclopentane-1-carbonitrile exemplifies the intersection of structural versatility and industrial applicability. Its relevance in high-value chemical synthesis ensures continued research interest, while evolving user queries reflect dynamic market needs—from cost-effective production to novel applications in life sciences and beyond.

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